Treatment of Histamine intolerance

Histamine intolerance occurs when histamines, chemicals released by the body in response to allergens, build up in the body and have a negative impact on health and well-being.

People with Histamine intolerance may experience symptoms such as headaches, nausea, digestive issues, rashes and more if they consume foods with high histamine content or aren’t able to break down histamines efficiently.

However, there are treatment options that can help alleviate symptoms and even heal Histamine intolerance over time. 

First steps in the treatment of histamine intolerance

There are very effective natural solutions for histamine Intolerance and Mast cell activation syndrome that can be added to the medical treatment or can be used alone. In the treatment of histamine intolerance and mast cell activation syndrome, if we think of natural substances, the same can be said, i.e. the goal is to reduce the amount of histamine in the body, so it is worth controlling the process of histamine breakdown and stabilizing mast cells. 

I did not take the natural treatment of histamine intolerance and MCAS separately because, like the symptoms, the proper natural active ingredients are similar too. However, the treatment of MCAS is a very complex thing. In many cases, when the immune system has calmed down, the asymptomatic stage can be maintained only by taking natural remedies. In histamine intolerance, with the help of natural supplements, you can become asymptomatic in the long run if the root cause is treated.

First of all, the cause of both histamine intolerance and mast cell activation syndrome should be explored. In the case of histamine intolerance, the first thing to think about is the inflammatory condition of the intestinal tract. I have described the causes in previous articles. Read them here: HIT  , MCAS

There is often a problem that the therapy used to eliminate the root causes is not tolerated by the individual. This is a major challenge for all diseases, especially MCAS. If you have severe histamine intolerance or MCAS, you may have severe symptoms of the medication you are taking for the root cause (such as parasites, lyme, SIBO, retroviruses, or molds).

The reaction is individual for everyone. It is also advisable to consult a specialist regarding natural active substances, who are experts in the natural treatment of these health conditions. However, it is a fact that certain substances can be used safely. It is worth switching the substances if possible and observing which is the most suitable active ingredient for you.

Based on the above, both Histamine intolerance and mast cell activation syndrome should be treated along the following 4 pillars*

1. Low histamine diet: Minimize your intake of histamine through food

2. Helping to breakdown histamine

3. Stabilization of mast cells

4. Stabilising the immune system and reducing inflammation

Here are the natural options that are best suited for treating histamine or mast cell activation problems.

1. Low histamine diet

To reduce histamine levels in your body, you should adopt a low histamine diet. Avoid the following:

Alcohol
Smoked and cured meat
Seafood
Pickled foods
Fermented foods
Leftovers
Canned sh or meat
Berries, especially strawberries (except blueberry)
Preservatives
Vinegar
Try to eat foods as fresh as possible, and stick to anti-inflammatory professional foods. See Low histamine food list

2. Helping to breakdown histamine

Diamine oxidase (DAO) stabilizes mast cells, but more importantly, it is the predominant enzyme besides HNMT enzyme that breaks down histamine. To increase your DAO levels, you can take DAO enzymes. You can also increase your DAO levels with high doses of vitamin C.
You should also avoid anything that blocks the release of DAO. Alcohol is in the first place in blocking the DAO. The worst thing happens when you drink alcohol, histamine is released from your mast cells, and DAO is simultaneously inhibited.

3. Stabilization of mast cells

If you would try any kind of natural supplement, I recommend the following:
Only pure and well-trusted formulations should be chosen. I have tried many kinds of natural supplements. It happened once that I had such intense diarrhea after taking that supplement that I needed to rebuild my gut flora from the beginning again.

I recommend a 3-day trial period with a lower dose of the new supplement before increasing the daily dose or the next supplement. My favorite supplement for stabilizing histamine release is Quercetin. If you want to know everything about the possible treatment, you will have the chance to get all the information on our membership site soon. Check back later.

Resources
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  • ChapowalA. PetasitesStudy Group. Randomisedcontrolled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324:144-6.
  • Hayes, N. A. and Foreman, J. C. The activity of compounds extracted from feverfew on histamine release from rat mast-cells. J Pharm Pharmacol1987;39(6):466-470
  • Hsieh et al. Baicalein inhibits IL-1ß- and TNF-a-induced inflammatory cytokine production from human mast-cells via regulation of the NF-?B pathway. ClinMolAllergy. 5: 5. 2007.
  • TheoharidesTC, Patra P, Boucher W, et al. Chondroitin sulphateinhibits connective tissue mast-cells. British Journal of Pharmacology. 2000;131(6):1039-1049. doi:10.1038/ sj.bjp.0703672.
  • Ro JY, Lee BC, Kim JY, et al. Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast-cells activated with specific antigenantibodyreactions. J PharmacolExpTher. 2000;292:114–121. 73.
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