GABA

GABA

Autism and Genes, Neuroplasticity

GABA the natural antidepressant

Gamma aminobutyric acid GABA, the calming neurotransmitter

 

 

 

Gamma-aminobutyric acid is a natural antidepressant that reduces stress, anxiety, helps with sleep, weight loss, and even has a beneficial effect on the symptoms of children with ADHD.

Gamma aminobutyric acid is an inhibitory neurotransmitter in the brain that regulates our brain’s and nerve cells’ activity by limiting the large number of anxiety-causing neurons in our brain, helping to form sedative brain waves, correcting stress-induced nutritional deficiencies and helping to relax. One of the main triggers for the symptoms of histamine intolerance include mental and physical stress. To reduce this, it is advisable to call on GABA for help.
This amino acid can also improve your growth hormone levels, which is a quick and straight path to a slim and muscular build. It makes cells even more susceptible/sensitive to insulin, which means less insulin is needed to get nutrients into the cells. According to research, GABA does not remove the feeling of hunger but has curbed weight gain. It inhibits the growth of fat cells and above all this, it may also help with insulin resistance that may result from intestinal problems.

What is gamma amino butyric acid good for?

Cardiovascular system
  • may lower blood pressure in patients with high blood pressure.
Digestive system
  • enhances the secretion of digestive enzymes.
Metabolism
  • may lower blood sugar levels in diabetic patients.
Musculoskeletal system
  • may help prevent and treat Rheumatoid Arthritis.
Nervous system
  • blocks anxiety-related nerve impulses from reaching the brain center.
  • can improve the condition of attention deficit and hyperactive patients.
  • binds to benzodiazepine receptors in the body.
  • calms the central nervous system.
  • is found in the cerebral cortex.
  • can help prevent the development of seizures.
  • supplementation can be used to treat depression and depressed patients. GABA levels in the brain are low in depressed patients.
  • Post-traumatic depression can be caused by too low a level of Gamma amino butyric acid.
  • Adequate GABA levels in the brain are needed in patients with epilepsy to prevent seizures.
  • reduces the activity of neurons in the brain.
  • Low GABA levels have been reported in panic patients. For this reason, supplemental consumption of GABA is also suitable for the treatment of panic disorder.
  • can help you get proper and restful sleep.
  • can block nerve impulses that are related to stress from reaching the brain.
Skin
  • increases the production of hyaluronic acid in the skin and exerts its antioxidant activity.

Additional physiological effects of GABA-gamma-aminobutyric acid?

  • It can lower your blood pressure
  • enhances the secretion of digestive enzymes, thus improving the digestive process.
  • may lower blood sugar levels in diabetic patients.
  • can help prevent and treat Rheumatoid Arthritis.
  • blocks anxiety-related nerve impulses from reaching the brain center.
  • can improve the condition of attention deficit and hyperacetic (ADHAD) children.
  • increases the levels of growth hormone in the body and helps reduce weight as well as increase muscle growth and recovery.
  • binds to benzodiazepine receptors in the body and is also used to treat addiction.
  • calms the central nervous system.
  • supplementation can be used to treat depression and depressed patients. GABA levels in the brain are low in depressed patients.
  • Post-traumatic depression can be caused by too low a level of GABA.
  • Adequate GABA levels in the brain are needed in patients with epilepsy to prevent seizures.
  • reduces the activity of neurons in the brain.
  • Low GABA levels have been reported in panic patients. For this reason, it is also suitable for the treatment of panic disorder
  • can help you get proper and restful sleep.
  • Increases the amount of hyaluronic acid in the skin
Resources
  • Abe, Y., et al.  Effect of green tea rich in gamma-aminobutyric acid on blood pressure of Dahl salt-sensitive rats.  Am J Hypertens.  8(1):74-79, 1995.
  • Nakagawa, T., et al.  Protective effects of gamma-aminobutyric acid in rats with streptozotocin-induced diabetes.  J Nutr Sci Vitaminol (Tokyo).  51(4):278-282, 2005.
  • Weeks, B. S.  Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action:  Relarian.  Medical Science Monitor.  15(11):RA256-262, 2009.
  • Braverman, Eric R.  The Healing Nutrients Within.  Keats Publishing, New Canaan, Connecticut, USA.  1997:240.
  • Epperson, C. N., et al.  Preliminary evidence of reduced occipital GABA concentrations in puerperal women:  a 1H-MRS study.  Psychopharmacology (Berl).  186(3):425-433, 2006.
  • GABA is a potent growth hormone elevator.  High Performance Muscle (AST Sports Science Catalog).  2001:88.

Omega 3 fatty acid

Omega 3 fatty acid

Autism and Genes, Health, Mitochondrial health

Omega-3 fatty acids belong to the group of polyunsaturated fatty acids, of which EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), and alpha-linolenic acid (ALA) are best known. Omega-3 has many properties that help maintain our health, and are an essential bioactive ingredient for children.

omega 3

Omega 3 is mainly an anti-inflammatory agent.

EPA has a strong anti-inflammatory effect and not enough DHA in the diet may reduce the ability to handle sensory input. It only takes a small decrement in brain DHA to produce losses in brain function. (1)

In humans, weak sensorimotor gating is a hallmark of many nervous-system disorders such as schizophrenia or ADHD. Given mounting evidence of the role omega-3s play in the nervous system, there is intense interest in their therapeutic potential, perhaps as a supplement to medicines. For example, people with schizophrenia have lower levels of essential fatty acids, possibly from a genetic variation that results in poor metabolism of these nutrients.

The finding connects low omega-3s to the information-processing problems found in people with schizophrenia; bipolar, obsessive-compulsive, and attention-deficit hyperactivity disorders; Huntington’s disease; and other afflictions of the nervous system.

Omega 3 fatty acid

Omega 3 fatty acid belongs to the group of polyunsaturated fatty acids, of which EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), and alpha linolenic acid (ALA) are best known. Omega 3 is an essential fatty acid.

Consumption of much marine fish is no longer recommended today due to the pollution of the seas. The most practical solution for consuming EPA, DHA, and GLA is by using high-quality fish oil, borage oil, or evening primrose oil in encapsulated form.

Main physiological effects of histamine intolerance and intestinal problems:

In terms of histamine intolerance, its main effect is its ability to reduce stress and reduce inflammation.

It also helps prevent the development of insulin resistance and has a positive effect on weight loss by helping to break down fat cells.

Physiological effects of Omega 3:

  • Due to their anti-inflammatory effect, it can reduce the risk of many diseases, such as vascular disease, Alzheimer’s disease, and some cancers. But fatty acids can also help treat diabetes, high blood pressure, and skin conditions.
  • Proper intake is essential for athletes due to the maintenance of the cardiovascular system, but it can also improve respiratory function and prevent asthma.
  • It helps the development of the fetus and reduces the incidence of preterm birth. It has a role in developing good visual acuity and mental development in infants.
  • Lower blood cholesterol levels, reducing the risk of atherosclerosis and heart attack.
  • It plays a role in the transport of fats, and the formation of anti-inflammatory prostaglandins, and their beneficial effects on the immune system are also known. And are involved in the structure of the nervous system and cell membranes.
  • Recent research has shown that children consuming omega-3 fatty acids regularly have improved their task-solving and problem-solving skills to understand tasks faster and improve school performance. Achieving optimal intake by children up to 14 is extremely important, as children’s brains develop to the greatest extent by the time they reach this age.
  • Omega 3 prevents the development of kidney stones

 

Other benefits of fish oil according to health problems:

Aging processes

Slows down the aging process.

Cardiovascular system
  • counteracts arrhythmia symptoms.
  • prevents tachycardia.
  • makes it easier to prevent atherosclerosis.
  • Prevents the development of cardiovascular disease.
  • improves heart function.
  • reduces elevated hematocrit levels.
  • lowers blood pressure in hypertensive patients.
  • reduces the development of Raynaud’s disease.
Digestive system
  • reduces the number of relapsing Crohn’s diseases.
  • prevents the formation of gallstones.
Eyes / vision
  • Fish oil prevents the development of macular degeneration (ARMD) in old age.
  • In the case of dry eyes, fish oil is effective in tear production.
  • In people with wolf blindness, fish oil can improve vision in the dark.
  • Fish oil is easy for the development and treatment of retinopathy.
Immune system
  • Children of women who consume fish oil during pregnancy have a lower rate of allergy.
  • Regular consumption of fish oil to avoid the development of autoimmune diseases.
  • Fish oil prevents the development of certain cancers.
  • It has an anti-inflammatory effect on fish oil.
Metabolism
  • enhances athletic performance.
  • reduces the absorption of cholesterol. Fish oil protects muscle fibers from toxic effects (catabolism).
  • prevents tired formation.
  • prevents the development of insulin resistance.
  • helps break down adipose tissue.
  • lowers triglyceride levels.
Musculoskeletal system
  •  reduces back pain.
  •  promotes bone formation.
  •  protects the muscles from the breakdown (catabolism).
  •  Fish oil is an option for the treatment of polymyalgia rheumatica.
  •  relieves the symptoms of rheumatoid arthritis.
Nervous system
  • reduces aggression.
  • have a beneficial effect on the behavior of patients with hyperactivity.
  • prevent the development of Alzheimer’s disease.
  • relieves depression.
  • has the potential for recovery after head injuries.
  •  improves learning ability.
  •  improves memory.
  •  relieves migraine symptoms.
  •  has the potential to relieve the symptoms of Multiple Sclerosis.
  •  is commonly used in the development of Parkinson’s disease.
  •  is used for schizophrenia.
  •  may be suitable for recovery from spinal cord injuries.
  •  alleviates the toxic effects of mental stress.
Respiratory system
  • may be useful in the treatment of acute respiratory distress syndrome (ARSD).
  •  improves respiratory function in asthmatic patients
  • prevents chronic lung disease.
  • easily prevents the development of bronchitis.
  • prevents emphysema.
  • easily improves lung function and reduce the risk of damage from smoking.
Hormanal problems
  • easily relieves menstrual cramps.
  •  reduces the heat waves associated with menopause and relieve depression.
  •  reduces the risk of developing male infertility.
Skin
  • reduces acne sufferers.
  • relieves the symptoms of eczema.
  • relieves itchy skin.
  • improves skin elasticity.
  • easily prevents sunburn in sensitive people.
  • speeds up wound healing.
Resources
[1]

Wijendran V, Huang MC, Diau GY, et al. Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonates. Pediatr Res 2002;51:265-272.

[2]

Goustard-Langelier B, Guesnet P, Durand G,et al. n-3 and n-6 fatty acid enrichment by dietary $sh oil and phospholipid sources in brain cortical areas and nonneural tissues of formula-fed piglets. Lipids 1999;34:5-16.

[3]

Maki KC, Reeves MS, Farmer M, et al. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr Res 2009;29:609-615.

[4]

Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004:9:420-428.

[5]

Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-179.

[6]

Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr 2007:26:39-48.

[7]

Chang JP, Chen YT, Su KP. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) in cardiovascular diseases (CVDs) and depression: Cardiovasc Psychiatry Neurol 2009;2009:725310. Epub 2009 Sep 27.

[8]

Breslow J. n-3 fatty acids and cardiovascular disease. Am J Clin Nutr 2006;83:1477S-1482S.

[9]

Calzolari I, Fumagalli S, Marchionni N, DiBari M. Polyunsaturated fatty acids and cardiovascular disease. Curr Pharm Des 2009;15:4094-4102.

[10]

No authors listed. Phosphatidylcholine. Altern Med Rev 2002;7:150-154.

[11]

Naguib YM. Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem 2000;48:1150-1154.

[12]

Tso P, Drake DS, Black DD, Sabesin SM. Evidence for separate pathways of chylomicron and very low-density lipoprotein assembly and transport by rat small intestine. Am J Physiol 1984;247:G599-G610.

[13]

Amate L, Gil A, Ramirez M. Feeding infant piglets formula with long-chain polyunsaturated fatty acids as triacylglycerols or phospholipids influences the distribution of these fatty acids in plasma lipoprotein fractions. J Nutr 2001;131:1250-1255.

[14]

Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic osteatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 2009;57:9339-9345.

[15]

Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th ed. New York, NY: Garland Science; 2002.

[16]

Else PL, Hulbert AJ. Membranes as metabolic pacemakers. Clin Exp Pharmacol Physiol 2003;30:559-564

[17]

Kidd PM. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Altern Med Rev. 2007 Sep;12(3):207-27.

[18]

Konagai C, Yanagimoto K, Hayamizu K, Han L, Tsuji T, Koga Y. Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers. Clin Interv Aging. 2013;8:1247-57.

[19]

Ebrahimi M, Ghayour-Mobarhan M, Rezaiean S, et al. Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Acta Cardiol. 2009 Jun;64(3):321-7.

[20]

Derosa G, Cicero AF, Fogari E, et al. Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load. J Clin Lipidol. 2012 Nov-Dec;6(6):553-64.

[21]

Spencer M, Finlin BS, Unal R, et al. Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Diabetes. 2013 May;62(5):1709-17.

[22]

Yan Y, Jiang W, Spinetti T, et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013 Jun 27;38(6):1154-63.

[23]

Valensa. FlexPro MD Clinical Trial Overview and Results. (Data on File.) 2011

[24]

McCann JC, Ames BN. Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr 2005;82:281-295.

[25]

Stevens LJ, Zentall SS, Abate ML, et al. Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiol Behav 1996;59:915-920.

    Quercetin

    Quercetin

    Autism and Genes, Histamine intolerance and MCAS, Methylation

    Quercetin is certainly one of the most exciting dietary flavonoids. It’s been linked to improved exercise performance and reduced inflammation, blood pressure, and blood sugar levels. Plus, it may have brain-protective, anti-allergy, and anticancer properties, and it is a natural antihistamine. 

    Numerous studies support the existence of a natural antihistamine because it regulates the release of histamine from basophils and mast cells (1). This regulatory mechanism can be used for various unwanted symptoms, allergies, asthma, and histamine intolerance symptoms.

    QUERCETIN suppresses the release of histamine from basophils and mast cells, so reduces the symptoms of histamine intolerance or mast cell activation syndrome (2)

    Other benefits

    • Reduces cellular inflammation
    • Prevention of allergies, in the alleviation of existing allergic symptoms
    • Protects the heart and nervous system
    • Prevention of osteoporosis, in the reduction of symptoms during menopause
    • May help in weight loss

    Allergies, Histamine intolerance

    The enzyme diamine oxidase (DAO) is responsible for the proper breakdown of histamine. Histamine plays an important role in the dynamic functioning of our body, but if the activity of the DAO enzyme decreases, we can experience various unpleasant symptoms due to high histamine levels: hives, eczema, swollen mouth, cough, runny nose, digestive problems, bloating, flatulence or abdominal pain. In these cases, the regulatory function of quercetin may be helpful.

    In addition to quercetin, DAO enzyme activity can be supported by supplementing other micronutrients. Among other things, zinc, copper, manganese, magnesium minerals, B vitamins (including choline and inositol), and vitamin C help proper production.

    Quercetin displays high antioxidant and anti-inflammatory properties that have been proven by many in vivo and in vitro studies. Its anti-allergic mechanism of action through the inhibition of enzymes and inflammatory mediators has also been extensively studied. It is well known that quercetin is an inhibitor of human mast cell activation through the inhibition of Ca2+ influx, histamine, leukotrienes, and prostaglandins release. The results of the studies prove the unique position of this supplement in the treatment of allergic disorders and the possibility of using phytochemicals such as quercetin for an efficient cure. (3)

     

    Antibacterial and antiviral activity

    This excellent flavonoid is known to exhibit antibacterial effects against almost all strains of bacteria, particularly affecting the gastrointestinal, respiratory, urinary, and dermal systems. (4)

    Cardiovascular health

    In 2008, a randomized, placebo-controlled crossover trial in 12 healthy men showed biochemical evidence of improved endothelial function (such as augmentation of nitric oxide status) with as little as 200 mg/day of quercetin. (5)

    Obesity

    This flavonoid actually blocks the uptake of glucose from the blood, depriving fat cells of the raw material they need to manufacture and accumulate fat molecules. (6)

    In another study, genistein, quercetin, and resveratrol together decreased lipid accumulation in fat cells by 17%, 20%, and 17%, respectively, the combination of all three agents decreased lipid accumulation by an impressive 80%. (7)

    Glutathione

    Glutathione

    Autism and Genes, Detoxification, Methylation

    Glutathione is the body’s most important antioxidant, found in every single cell.

    It is also called a “master antioxidant” because it exerts its effects within cells and its unique ability to maximize the effects of all other antioxidants, including vitamins C and E, Q10 + Ubiquinol, alpha-lipoic acid.

     

     

     

    Glutathione is the body’s most important antioxidant in every cell.

    It is also called a “master antioxidant” because it exerts its effects on cells and unique ability to maximize the impact of all other antioxidants.

    Glutathione

    The primary function of Glutathione is to protect cells and mitochondria from the damaging, destructive effects of internal oxidation processes [1]. It covers the integrity of our cells, tissues, and organs, thus playing an essential role in the fight against chronic diseases associated with aging.

    Glutathione is key to detoxification, neutralizing toxins in the body, and protecting against the harmful effects of radiation, chemicals, and environmental contaminants.

    It improves the functioning of the immune system, has a nervous system protection effect, increases the body’s resistance to infections, can speed up the recovery from diseases, and increases the body’s energy levels and vitality [2].

    Why you should keep the glutathione level high?

    To achieve optimal health and longevity, the body’s glutathione levels should be kept high [3]. Glutathione levels are significantly reduced by diseases, infections, stress, malnutrition, environmental pollution, poisoning, and aging.

    Deficiency of this master antioxidant has been linked to several diseases: immune system disorders, nervous system problems, autoimmune processes, lack of energy, impaired detoxification function, muscle weakness, inflammatory conditions, and cellular malignancies [4].

    GSH is a critical component of our antioxidant defense system. This molecule is made up of three amino acids (cysteine, glutamic acid, glycine) that are produced in small amounts by our body. Still, in many cases, our body needs replacement.

    Contrary to popular belief, it can be demonstrated that during oral administration of the molecule, it is not degraded in the acidic medium of the stomach but is absorbed from the intestinal tract into the bloodstream and reaches the cells [5].

    The liver contains a large amount of Glutathione, which shows its important role in the body’s detoxification processes. Low glutathione levels are present in many chronic diseases and weakened immune systems, so the elderly, physically and mentally stressed people, and the weakened immune system need Glutathione!

     

    Benefits of Glutathione

    • Cellular energy supply
    • For optimal functioning of the immune system, to promote effective inflammation reduction.
    • Control of various infections
    • Prevention of malicious processes. Increase the energy supply at the cellular level to balance the mitochondria and reduce the harmful effects of oxidative stress
    • Support of the nervous system
    • Adjunctive treatment of autoimmune conditions (e.g., Hashimoto)
    • In the adjunctive treatment of gynecological problems such as endometriosis, fibroids

    Immunological effects

    • For a healthy immune system, protection against infections and autoimmune processes. Glutathione plays a vital role in maintaining the healthy functioning of the immune system.
    • Oxidative stress caused by viral infections causes inflammation in the cells, and glutathione levels are demonstrably reduced.
    • Decreased immunity and an increased risk of infections are associated with low glutathione levels [6]. Glutathione is beneficial in increasing the number of T cells in immune leukocytes and NK cells in natural killer cells [7].
    • Glutathione deficiency can be detected in autoimmune diseases. Research has shown that Glutathione has a positive effect on the normal functioning of the immune system and prevents the development of an immune response and inflammation in autoimmune diseases [8].

    Detoxification

    • Oxidation is healthy to some extent (e.g., sports). However, excessive oxidation is already harmful. This can be caused by unhealthy lifestyles, stress, malnutrition, and external environmental toxins.
    • The antioxidant system of a healthy young body seeks to protect it from external and internal oxidative effects to prevent tissue wear and tear, thus slowing the aging process so that our cells can remain young and healthy for a long time.
    • It is important for recycling other antioxidants, such as vitamins C and E and Q10+ Ubiquinol.
    • Glutathione is found in the highest concentrations in the liver and kidneys. [9].Helps remove toxins, foreign chemicals, potential carcinogens, hormones, and pollutants. It converts them into water-soluble substances that can now be easily excreted from the body through the kidneys.
    • Promoting the detoxifying processes of the liver
    • The detoxification ability of Glutathione can be further enhanced by other sulfur-containing molecules: cruciferous plants (broccoli), r-alpha-lipoic acid, N-acetyl cysteine, turmeric, St. John’s wort, and B vitamins, selenium.
    • This molecule is also present in the entire intestinal mucosa, where it traps and neutralizes potential toxins before they are absorbed into the body. It protects the intestinal wall, which, if weakened, can lead to a leaking / permeable intestinal problem [10].

    Other benefits

    • Protecting the brain and nervous system: Our brain uses a lot of oxygen and is highly vulnerable to oxidative damage. This oxidative damage adversely affects neurological functions and development, leading to mitochondrial dysfunction and several neurodegenerative diseases. Glutathione protects brain cells against oxidation. Low glutathione levels increase the risk of developing neurodegenerative diseases [11].
    • Heavy metals accumulate in the brain and can cause severe oxidative stress and cell damage. Glutathione can detoxify toxic metals in the brain, thereby protecting the health of the nervous system.
    • Energy production of cells, enhancement of vitality
    • Mitochondria are responsible for our cells’ energy production in the form of adenosine triphosphate (ATP), the body’s fuel. The function of mitochondria also plays a vital role in cell health, intercellular communication, regulated cell death, and cell growth. Glutathione can potentially improve mitochondrial health and affect our energy-producing abilities [12].
    • Glutathione can help to disappear gray hair and restores the original hair color (13)
    • A small study published in Medical Science Monitor in 2011 shows a connection between low glutathione levels and autism spectrum disorders. (14, 15)
    Resources

     

    • [1] Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio F. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018 Jul;52(7):751-762
    • [2] Samuni Y, Goldstein S, Dean OM, Berk M. The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta. 2013 Aug;1830(8):4117-29.
    • [3] Fulghesu AM, Ciampelli M, Muzj G, et al. N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril. 2002 Jun;77(6):1128-35.
    • [4] Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009 Feb;181(2):741-51.
    • [5] Badawy A, State O, Abdelgawad S. N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial. Acta Obstet Gynecol Scand. 2007;86(2):218-22.
    • [6] Porpora MG, Brunelli R, Costa G, Imperiale L, Krasnowska EK, Lundeberg T, Nofroni I, Piccioni MG, Pittaluga E, Ticino A, Parasassi T. A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine. Evid Based Complement Alternat Med. 2013;2013:240702.
    • [7] Stey C, Steurer J, Bachmann S, Medici TC, Tramèr MR. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J. 2000 Aug;16(2):253-62.
    • [8] Stav D, Raz M. Effect of N-acetyl cysteine on air trapping in COPD: a randomized placebo-controlled study. Chest. 2009 Aug;136(2):381-6.
    • [9] Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A. A Review on Various Uses of N-Acetyl Cysteine. Cell J. 2017;19(1):11-17. doi:10.22074/cellj.2016.4872
    • [10] Sandhir R, Sood A, Mehrotra A, Kamboj SS. N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington’s disease. Neurodegener Dis. 2012;9(3):145-57.
    • [11] Shungu DC. N-acetylcysteine for the treatment of glutathione deficiency and oxidative stress in schizophrenia. Biol Psychiatry. 2012 Jun 1;71(11):937-8.

    Berberine for diarrhea

    Berberine for diarrhea

    Gut-Brain Axis, Health, Microbiome and Gut health, Natural medicines

    berberine

    Studies have confirmed that the bacteriostatic effect of BERBERINE plays a role in improving SIBO symptoms; berberine lowers blood sugar, reduces blood fat, and improves arrhythmias, and cardiovascular disease, reducing the risk and preventing cancer.

     

     

     

    Berberine optimizes blood sugar, plays a role in reducing blood fat, reduces the risk of cardiovascular disease, and last but not least, relieves diarrheal symptoms due to its bacteriostatic effect and can be used effectively with SIBO.

    Berberine, the herbal agent for diarrhea

    Berberin is a herbal agent for diarrhea, but you should be careful because, like antibiotics, Berberine kills good bacteria as well.

     

    Physiological effects of berberine 

    • Insulin resistance often develops as a result of intestinal problems. Berberin’s blood sugar optimizing effect prevents the development of insulin resistance and reverses existing insulin resistance, and promotes weight loss
    • It inhibits the growth of pathogens that cause diarrhea, thereby relieving the symptoms of diarrhea. It can be a great help in case of intestinal inflammation problems, even in SIBO (Small Intestine Bacterial Overgrowth) This natural herbal active ingredient, an alkaloid, can effectively control blood sugar levels – even insulin resistance. Studies have confirmed that the bacteriostatic effect of berberine plays a role in lowering blood sugar, reducing blood fat, improving arrhythmias, and cardiovascular disease, reducing the risk, and preventing cancer. Of these, the effectiveness of reducing blood sugar and blood lipids has been clinically proven by Chinese researchers.
    • Berberin also can effectively reduce the risk of cancer.
    • Research shows that it has a beneficial effect on cholesterol levels by activating the enzyme protein kinase (AMPK), which regulates the metabolism of fats and carbohydrates, and increases the response to the insulin produced by the pancreas

    Other physiological effects

    • Accelerate wound healing
    • Weight loss
    • Mild sedation
    • Kidney protection
    • Protection against harmful radiation
    • Muscle relaxation 
    • Antihypertensive effect
    • Supports cardiovascular function
    • Prevention of gastric ulcer
    • It has an antioxidant effect and lowers cholesterol It has an anti-inflammatory effect and a fungicidal effect It is also effective in preventing or alleviating diarrhea. Berberine is able to fight pathogenic microorganisms and inhibit various bacteria, such as dysentery bacteria
    Resources

    • Studies on the effect of Berberine

      SIBO/IBS

      https://pubmed.ncbi.nlm.nih.gov/26400188/
      https://the-unwinder.com/reviews/berberine-for-sibo/

      Weigt loss

      https://www.sciencedirect.com/science/article/pii/S0753332220303292

      Diabetes Type 2

      https://www.everydayhealth.com/type-2-diabetes/potential-benefits-berberine-type-2-diabetes/
      https://www.everydayhealth.com/type-2-diabetes/potential-benefits-berberine-type-2-diabetes/

      Cholesterol

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871262/
      https://pubmed.ncbi.nlm.nih.gov/15926873/
      https://www.verywellhealth.com/berberine-lowers-cholesterol-698106
      https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05028-8

      PCOS

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028834/
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261244/
      https://www.hindawi.com/journals/ecam/2019/7918631/
      https://www.clinicaltrials.gov/ct2/show/NCT01138930

    The glutathione precursor

    The glutathione precursor

    Autism and Genes, Detoxification, Health, Microbiome and Gut health

    N-Acetyl-L-Cysteine (NAC) is one of the most exciting antioxidant amino acids of our time. An anti-inflammatory agent, one of the precursors to glutathione, which referred to as a master antioxidant (1). That is why we recommend the combined use of our NAC and Glutathione products.

    The mucolytic, antitussive effect of NAC has long been known in the health circles because of its ability to break down disulfide bridges in mucus and secretions (1).

    New research has highlighted other important aspects: its effects on stabilizing blood sugar levels (2) (insulin resistance, adjusting blood fat levels), increasing fertility and protecting the nervous system have innovative potential.

    N-Acetyl Cystein the glutathione precursor

    “The glutathione precursor” what does it mean? Glutathione, also known as GSH, is a molecule found naturally in your body. It is produced by the liver and nerve cells in the central nervous system. Glutathione is made up of three amino acids: L-cysteine, glycine, and L-glutamate.
    Glutathione is an antioxidant, a molecule that helps fight free radicals. When more free radicals exist than antioxidants, oxidative cell damage occurs. This can lead to inflammation and a variety of health issues.
    In addition to being an antioxidant,

    Acetyl-L-Cysteine (NAC) is one of the most exciting antioxidant amino acids of our time. An anti-inflammatory agent, one of the precursors to glutathione, which referred to as a master antioxidant [1].

    A Powerful Antioxidant

    N-acetylcysteine, derived from the simple amino acid cysteine, provides significant protection against a broad array of modern toxins. 

    NAC is a precursor of glutathione. Glutathione is the body’s most important antioxidant, found in every single cell. It is also called a “master antioxidant” because it exerts its effects within cells and its unique ability to maximize the effects of all other antioxidants, including vitamins C and E, Q + Ubiquinol, r-alpha-lipoic acid.

    The primary function of Glutathione is to protect cells and mitochondria from the damaging, destructive effects of internal oxidation processes (2). It protects the integrity of our cells, tissues and organs, thus playing an important role in the fight against chronic diseases associated with aging. Glutathione is key to detoxification, neutralizing toxins in the body, protecting against the harmful effects of radiation, chemicals and environmental contaminants.

    It improves the functioning of the immune system, has a nervous system protection effect, increases the body’s resistance to infections, can speed up the recovery from diseases, and increases the body’s energy levels and vitality (3).

    For a healthy immune system

    Glutathione plays an important role in maintaining the healthy functioning of the immune system. Oxidative stress caused by viral infections causes inflammation in the cells and glutathione levels are demonstrably reduced.

    Decreased immunity and an increased risk of infections are associated with low glutathione levels (4). Glutathione is beneficial in increasing the number of T cells in immune leukocytes and NK cells in natural killer cells (5). Glutathione deficiency can be detected in autoimmune diseases.

    Research has shown that glutathione has a positive effect on the normal functioning of the immune system and prevents the development of an excessive immune response and inflammation in autoimmune diseases (6).

    Liver protection, detoxification

    Glutathione is found in the highest concentrations in the liver and kidneys. The liver plays a prominent role in the II. in phase detoxification processes (7). Helps remove toxins, foreign chemicals, potential carcinogens, hormones, pollutants.

    It converts them into water-soluble substances that can now be easily excreted from the body through the kidneys. Glutathione is also present in the entire intestinal mucosa, where it captures and neutralizes potential toxins before they are absorbed into the body. Glutathione protects the intestinal wall, which, if weakened, can lead to a leaking / permeable intestinal problem (8).

    The detoxification ability of glutathione can be further enhanced by other sulfur-containing molecules: cruciferous plants (broccoli), r-alpha-lipoic acid, N-acetyl cysteine, turmeric, St. John’s wort and B vitamins, selenium, and the like. 

    Excessive consumption of over-the-counter drugs containing paracetamol (eg, antipyretics, analgesics, etc.) can lead to hepatotoxicity and deplete the body’s glutathione system. NAC is able to rehabilitate toxic processes in liver cells.

    Acetyl-L-Cysteine increases the body’s glutathione levels, enhances the immune system through its antioxidant effect, helps cellular regeneration and reduce inflammation, and contributes to the effective elimination of toxins and toxins.

    It contributes to the multi-level detoxification processes of the liver, and also promotes the rehabilitation of liver cells in the state of fatty liver. In this case, Choline and Inositol can help in the detoxification process.

    Protecting the brain and nervous system

    Our brain uses a lot of oxygen and is therefore extremely vulnerable to oxidative damage. This oxidative damage adversely affects neurological functions and our development, which can lead to mitochondrial dysfunction and a number of neurodegenerative diseases. Glutathione protects brain cells against odiation.

    Low glutathione levels increase the risk of developing neurodegenerative diseases. Heavy metals that accumulate in the brain can cause severe oxidative stress and cell damage. Glutathione has the ability to detoxify toxic metals in the brain, thereby protecting the health of the nervous system (9).

    Energy production of cells, enhancement of vitality

    Mitochondria are responsible for the energy production of our cells in the form of adenosine triphosphate (ATP). The function of mitochondria also plays a vital role in cell health, intercellular communication, regulated cell death, and cell growth.

    Researchers today believe that mitochondrial health is directly linked to our aging processes and the resistance of cells to degenerative diseases. Glutathione has the potential to improve mitochondrial health and directly affect our energy-producing abilities.

    By-products of cellular metabolism are also free radicals that are destructive. They are also able to neutralize glutathione (10).

    NAC in relation to the hormonal system and fertility

    Research results support its effectiveness in reducing ROS (reactive oxygen species) levels, combined with vitamins A, E and Omega-3 fatty acids. Other literature has also described the combination of NAC and selenium as effective (11). High ROS levels presuppose inflammation and affect the DNA of sperm.

    It supports the ovarian cycle, i.e. the cycle of ovulation, thereby positively affecting fertility (12). By stimulating glutathione levels, it has a positive effect on insulin secretion and increases insulin sensitivity, so it can be used as an adjunct in the treatment of insulin-resistant conditions in polycystic ovary syndrome, which is closely related to insulin resistance (13).

    Furthermore, a human study highlights the effect of NAC on cysts that cure-like use of NAC may reduce the potential for cysts due to endometriosis (14). In such cases, I strongly recommend Glutathione, Choline + Inositol.

    The role of NAC in the functioning of the respiratory system

    As a mutolytic, Acetyl-L-Cysteine ​​supports the emptying of difficult-to-break secretions and can therefore help with prolonged, persistent coughs (colds, flu, bronchitis (15).

    Research has been shown to be effective in the adjunctive treatment of COPD [8]. Due to its powerful antioxidant effect, it can reduce the condition of chronic inflammation. According to the research, Acetyl-L-Cysteine ​​intake promoted physical activity and performance in patients with COPD.

    By increasing glutathione levels, it can reduce the inflammatory state of lung tissue and contribute to its regeneration.

    What else does NAC help

    • To clean the lungs of the secretion due to smoking.
    • In the adjunctive treatment of COPD
    • Prevention of respiratory infections, alleviation of pre-existing symptoms (persistent cough)
    • Endometriosis, in the adjunctive treatment of PCOs for fertility problems (both women and men)
    • In post-contraceptive rehabilitation (in such cases we also recommend our Broccoli & Watercress, Choline & Inositol products)
    • To detoxify the liver, regenerate liver cells, lower triglycerides In case of blood sugar and insulin homeostasis problems, in the adjunctive treatment of insulin resistance
    • Nervous system, to support nerve cells and to increase memory
    • Metabolism of toxins and cancer-causing substances
    • Natural creation and repair of DNA
    • Production of protein and prostaglandin, a compound with hormone-like effects
    • Activation of enzymes
    • Glutathione also helps with the breakdown of nutrients and the regulation of important body processes, such as the immune response.
    • A small study published in Medical Science Monitor in 2011 shows a connection between low glutathione levels and autism spectrum disorders.
    • The mucolytic, antitussive effect of NAC has long been known in the health circles because of its ability to break down disulfide bridges in mucus and secretions .
    • It is also used as an antidote in problems with paracetamol overdose to protect liver cells.
    • New research has highlighted other important aspects: its effects on stabilizing blood sugar levels (insulin resistance, adjusting blood fat levels), increasing fertility and protecting the nervous system have innovative potential.
    • N-acetylcysteine (NAC) is effective both in inhibiting biofilm formation and in destroying developed biofilms. (12)
    Resources
    • [1] Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio F. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018 Jul;52(7):751-762
    • [2] Samuni Y, Goldstein S, Dean OM, Berk M. The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta. 2013 Aug;1830(8):4117-29.
    • [3] Fulghesu AM, Ciampelli M, Muzj G, et al. N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril. 2002 Jun;77(6):1128-35.
    • [4] Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009 Feb;181(2):741-51.
    • [5] Badawy A, State O, Abdelgawad S. N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial. Acta Obstet Gynecol Scand. 2007;86(2):218-22.
    • [6] Porpora MG, Brunelli R, Costa G, Imperiale L, Krasnowska EK, Lundeberg T, Nofroni I, Piccioni MG, Pittaluga E, Ticino A, Parasassi T. A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine. Evid Based Complement Alternat Med. 2013;2013:240702.
    • [7] Stey C, Steurer J, Bachmann S, Medici TC, Tramèr MR. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J. 2000 Aug;16(2):253-62.
    • [8] Stav D, Raz M. Effect of N-acetyl cysteine on air trapping in COPD: a randomized placebo-controlled study. Chest. 2009 Aug;136(2):381-6.
    • [9] Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A. A Review on Various Uses of N-Acetyl Cysteine. Cell J. 2017;19(1):11-17. doi:10.22074/cellj.2016.4872
    • [10] Sandhir R, Sood A, Mehrotra A, Kamboj SS. N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington’s disease. Neurodegener Dis. 2012;9(3):145-57.
    • [11] Shungu DC. N-acetylcysteine for the treatment of glutathione deficiency and oxidative stress in schizophrenia. Biol Psychiatry. 2012 Jun 1;71(11):937-8.
    • [12] https://pubmed.ncbi.nlm.nih.gov/25339490/

    Treatment of histamine intolerance

    Treatment of histamine intolerance

    Histamine intolerance and MCAS, Methylation

    Treatment of Histamine intolerance

    Histamine intolerance occurs when histamines, chemicals released by the body in response to allergens, build up in the body and have a negative impact on health and well-being.

    People with Histamine intolerance may experience symptoms such as headaches, nausea, digestive issues, rashes and more if they consume foods with high histamine content or aren’t able to break down histamines efficiently.

    However, there are treatment options that can help alleviate symptoms and even heal Histamine intolerance over time. 

    First steps in the treatment of histamine intolerance

    There are very effective natural solutions for histamine Intolerance and Mast cell activation syndrome that can be added to the medical treatment or can be used alone. In the treatment of histamine intolerance and mast cell activation syndrome, if we think of natural substances, the same can be said, i.e. the goal is to reduce the amount of histamine in the body, so it is worth controlling the process of histamine breakdown and stabilizing mast cells. 

    I did not take the natural treatment of histamine intolerance and MCAS separately because, like the symptoms, the proper natural active ingredients are similar too. However, the treatment of MCAS is a very complex thing. In many cases, when the immune system has calmed down, the asymptomatic stage can be maintained only by taking natural remedies. In histamine intolerance, with the help of natural supplements, you can become asymptomatic in the long run if the root cause is treated.

    First of all, the cause of both histamine intolerance and mast cell activation syndrome should be explored. In the case of histamine intolerance, the first thing to think about is the inflammatory condition of the intestinal tract. I have described the causes in previous articles. Read them here: HIT  , MCAS

    There is often a problem that the therapy used to eliminate the root causes is not tolerated by the individual. This is a major challenge for all diseases, especially MCAS. If you have severe histamine intolerance or MCAS, you may have severe symptoms of the medication you are taking for the root cause (such as parasites, lyme, SIBO, retroviruses, or molds).

    The reaction is individual for everyone. It is also advisable to consult a specialist regarding natural active substances, who are experts in the natural treatment of these health conditions. However, it is a fact that certain substances can be used safely. It is worth switching the substances if possible and observing which is the most suitable active ingredient for you.

    Based on the above, both Histamine intolerance and mast cell activation syndrome should be treated along the following 4 pillars*

    1. Low histamine diet: Minimize your intake of histamine through food

    2. Helping to breakdown histamine

    3. Stabilization of mast cells

    4. Stabilising the immune system and reducing inflammation

    Here are the natural options that are best suited for treating histamine or mast cell activation problems.

    1. Low histamine diet

    To reduce histamine levels in your body, you should adopt a low histamine diet. Avoid the following:

    Alcohol
    Smoked and cured meat
    Seafood
    Pickled foods
    Fermented foods
    Leftovers
    Canned sh or meat
    Berries, especially strawberries (except blueberry)
    Preservatives
    Vinegar
    Try to eat foods as fresh as possible, and stick to anti-inflammatory professional foods. See Low histamine food list

    2. Helping to breakdown histamine

    Diamine oxidase (DAO) stabilizes mast cells, but more importantly, it is the predominant enzyme besides HNMT enzyme that breaks down histamine. To increase your DAO levels, you can take DAO enzymes. You can also increase your DAO levels with high doses of vitamin C.
    You should also avoid anything that blocks the release of DAO. Alcohol is in the first place in blocking the DAO. The worst thing happens when you drink alcohol, histamine is released from your mast cells, and DAO is simultaneously inhibited.

    3. Stabilization of mast cells

    If you would try any kind of natural supplement, I recommend the following:
    Only pure and well-trusted formulations should be chosen. I have tried many kinds of natural supplements. It happened once that I had such intense diarrhea after taking that supplement that I needed to rebuild my gut flora from the beginning again.

    I recommend a 3-day trial period with a lower dose of the new supplement before increasing the daily dose or the next supplement. My favorite supplement for stabilizing histamine release is Quercetin. If you want to know everything about the possible treatment, you will have the chance to get all the information on our membership site soon. Check back later.

    Resources
    • m B-R, SeoH-S, Ku J-M, et al. Silibinininhibits the production of pro-inflammatory cytokines through inhibition of NF-κB signaling pathway in HMC-1 human mast-cells. Inflammation. Research. 2013;62(11):941-950. doi:10.1007/s00011-013-0640-1.
    • ChapowalA. PetasitesStudy Group. Randomisedcontrolled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324:144-6.
    • Hayes, N. A. and Foreman, J. C. The activity of compounds extracted from feverfew on histamine release from rat mast-cells. J Pharm Pharmacol1987;39(6):466-470
    • Hsieh et al. Baicalein inhibits IL-1ß- and TNF-a-induced inflammatory cytokine production from human mast-cells via regulation of the NF-?B pathway. ClinMolAllergy. 5: 5. 2007.
    • TheoharidesTC, Patra P, Boucher W, et al. Chondroitin sulphateinhibits connective tissue mast-cells. British Journal of Pharmacology. 2000;131(6):1039-1049. doi:10.1038/ sj.bjp.0703672.
    • Ro JY, Lee BC, Kim JY, et al. Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast-cells activated with specific antigenantibodyreactions. J PharmacolExpTher. 2000;292:114–121. 73.
    • https://www.ncbi.nlm.nih.gov/pubmed/24477254
    • https://www.ncbi.nlm.nih.gov/pubmed/28458279
    • https://www.ncbi.nlm.nih.gov/pubmed/9421440
    • https://www.ncbi.nlm.nih.gov/pubmed/10344773
    • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315779/
    Gut Microbiome test

    Gut Microbiome test

    Autism and Genes, Gut-Brain Axis, Health, Microbiome and Gut health

    A gut microbiome test is needed if any kind of abdominal, neurological, or skin complaint is present. It gives relevant information on gut health.

     

     

     

    Research shows that your gastrointestinal (GI) system state (or your “gut”) influences your overall health.

    While certain symptoms, such as indigestion, mood changes, and skin diseases, could point to imbalances in the gut, these exact connections can only be understood through testing.

    This is where microbiome testing could potentially play a role.

    A gut microbiome test is a new diagnostic way to get a picture of your overall health.

    Microbiome testing measures the amount and types of microbes in your gut, such as bacteria and viruses, via a stool sample. While such tests may be conducted in a doctor’s office, there are at-home tests too when you have to complete the microbiome testing kits on your own.

    A gut microbiome refers to the microbes that exist in your digestive system. The intestines, stomach, colon, and esophagus are all important members of your GI tract, and they all contain microbes that affect the digestion process.

    Composition of the gut microbiome

    You probably know that billions of microorganisms live in our bodies, mostly located in the gastrointestinal tract.  The human genome consists of about 23,000 genes, whereas our microbiome encodes over 3 million genes that produce thousands of metabolites. This means that in the human body there is a superorganism that plays an important role.

    Everyone has a unique microbiota like a personal fingerprint and this means that gut microbiota composition is mostly unique to each individual, like an individual identity card.

    Current evidence points mostly towards that humans live in a sterile environment in the womb and infants only start being colonized by microbes when going through the vaginal passage, or during skin contact with parents or the medical team. The human microbiota is established in this phase and starts as a dynamic ecosystem that stabilizes during the first 2–3 years.

     

    Composition is influenced by:

    • Feeding methods (breast milk, artificial milk, and introduction of solid food);
    • Medication (antibiotics, acid suppressants, drugs);
    • Dietary habits; environment and lifestyle; and weight gain.
    • Genetics factors;
    • Anatomical parts of the intestinal tract (e.g. the large intestine has a higher microbial diversity compared with the small intestine);
    • Gestational age (preterm or full-term birth); delivery mode (vaginal delivery or C-section); and aging.
      The microbiomes have many essential functions in the body: from helping digestion and producing vitamins to supporting the development of the immune system and preventing infections.
    • Impressively there are also interactions between gut microbes and the brain which means we may be able to support mental health by changing the gut microbiome.
    • The microbiome functions as an extra organ, that uses nutrients from ingested foods to produce a large number of compounds, including vitamins, short chain fatty acids (SCFAs), and essential amino acids. The gut microbiome, through metabolite production and fermentation, helps the intestine to maintain its equilibrium. When a balanced interaction between the gastrointestinal (GI) tract and the resident microbiota is disrupted, intestinal and extra-intestinal diseases may develop.
    When there’s an imbalance of gut microbes, various health effects may occur as a result. Common symptoms of gut disruptions may include bloating, stool changes, and heartburn,diarrhea,mood swings,skin disorders such as eczema,POD ( peioralis dermatitis)and rashes on any part of the body, SIBO, inflammation, insuline resistance…and so on.

    Furthermore
    Your gut health affects your brain through neurotransmitters (serotonin contributes to feelings of happiness, gaba – gamma- aminobutyric reduces anxiety ) and these neurotransmitters are produced by gut cells and gut microbes.

    Why test your microbiome?

    The primary purpose of this type of stool testing is to analyze microbes and potential imbalances in your GI system. This kind of stool sample analysis can provide clues to potential inflammatory conditions or autoimmune diseases, such as inflammatory bowel disease (IBD) and Celiac disease.
    By testing your gut microbiome, you can learn more about the functions of your gut microbiome and check that it is helping to keep you healthy and not contributing to making you sick. Using a metagenomic gut microbiome test, you will learn your potential to break down nutrients and discover the potential of your gut microbiome to break down macronutrients such as fiber, protein, simple sugars, and fats.
    obtain a comprehensive list of the microbial species present
    Whether it’s a well-known species or newly discovered, you will get a full list of the different bacteria and archaea present in your gut.

    Receive tailored guidance from a Microbiome Coach

    If the detailed information about the result of your microbiome test is not enough for you, it is possible to ask for help from a Microbiome coach who helps in evaluating your test result. Gain a deeper understanding of your Insight™ report and discuss your personalized shopping list of food suggestions with a qualified health professional.

    Resources
    • [1] https://pubmed.ncbi.nlm.nih.gov/28743984/
    • [2] https://pubmed.ncbi.nlm.nih.gov/30025401/
    • [3] https://pubmed.ncbi.nlm.nih.gov/27812084/
    • [4] https://pubmed.ncbi.nlm.nih.gov/28512250/
    • [5] Thriene K. et al. Effects of Fermented Vegetable Consumption on Human Gut Microbiome Diversity—A Pilot Study. Fermentation. ;8(3).(2022).
    • [6] Sarka A et al. Pychobiotucs and the Manipulation of Bacteria-Gut-Brain Signlas. Trends in Neurosciences. (2016).
    • [7] Bear T et al. The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress. Microorganisms. (2021)
    • [8] Miranda-Comas G. et al. Implications of the Gut Microbiome in Sports. Sports Health (2022).
    • [9] Day AW. et al. Gut Microbiome Dysbiosis in Alcoholism: Consequences for Health and Recovery. (2022).
    • [10] Leclercq S. et al. Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms. Transl Psychiatry. ;11(1):503. (2021).
    • [11] Seo B et al. Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice. Cell host & microbe. ;27(1):25-40.e6. (2020).
    • [12] Flikkema J. The Relationship Between the Gut Microbiome and Sleep Examined Through Associated Human Disease. University Honors Theses. (2022).
    • [13] Han M. et al.. The interplay between sleep and gut microbiota. Brain Research Bulletin. (2022).