Gut-Brain Axis, Weight Loss Supplements
The Microbiome-Weight Connection
The human gut microbiome—trillions of bacteria, fungi, and other microbes—plays a crucial role in metabolism, digestion, and even weight regulation. An imbalanced microbiome (low diversity or an overgrowth of harmful bacteria) is increasingly linked to obesity and metabolic disorders.
Emerging research suggests that increasing gut microbiome diversity through dietary strategies, such as consuming a variety of fibers and fermented foods, can support healthy weight management. But how does this work?
Fiber: The Fuel for a Diverse Gut
Dietary fiber isn’t just for digestion—it acts as a prebiotic, feeding beneficial gut bacteria and promoting their growth. However, not all fiber is created equal. To support a diverse microbiome, you need a variety of fiber types:
- Soluble Fiber (oats, beans, lentils, flaxseeds) dissolves in water, forming a gel that slows digestion and supports gut bacteria like Bifidobacteria.
- Insoluble Fiber (whole grains, vegetables, nuts) adds bulk to stool and supports motility, preventing gut stagnation.
- Resistant Starch (green bananas, cooked and cooled potatoes, legumes) resists digestion in the small intestine, reaching the colon where it ferments and feeds beneficial bacteria.
- Polyphenol-Rich Fiber (berries, dark chocolate, coffee, tea) nourishes beneficial microbes while reducing inflammation.
The more diverse your fiber intake, the more robust and balanced your microbiome, leading to improved digestion, reduced cravings, and better metabolic efficiency.
Fermented Foods: Feeding Your Gut with Probiotics
While fiber fuels good bacteria, fermented foods directly introduce beneficial microbes (probiotics) to your gut. These foods contain live bacteria that can reshape the microbiome and improve weight management by enhancing digestion, reducing inflammation, and balancing metabolism.
The best fermented foods for gut health include:
- Yogurt (with live cultures) – Contains Lactobacillus and Bifidobacteria strains that improve digestion and reduce gut inflammation.
- Kefir – A potent probiotic drink with diverse bacterial and yeast cultures.
- Kimchi and Sauerkraut – Fermented vegetables that support microbial diversity and metabolic health.
- Kombucha – A fermented tea rich in probiotics and organic acids that support digestion.
- Miso and Tempeh – Fermented soy products that provide both probiotics and plant-based protein.
How a Healthy Microbiome Supports Weight Management
A diverse gut microbiome influences weight management in several ways:
- Improved Metabolism – Beneficial microbes help extract and process energy from food more efficiently, reducing excess fat storage.
- Appetite Regulation – Gut bacteria influence hunger hormones like ghrelin and leptin, helping regulate cravings.
- Reduced Inflammation – A balanced microbiome lowers chronic inflammation, which is linked to obesity and metabolic syndrome.
- Better Blood Sugar Control – A healthy gut supports stable blood sugar levels, reducing insulin resistance and fat accumulation.
How to Implement These Changes
- Eat 30+ different plant-based foods per week to maximize fiber diversity.
- Incorporate fermented foods daily, starting with small amounts to allow your gut to adjust.
- Limit processed foods and excess sugar, which disrupt microbial balance.
- Stay hydrated to support digestion and fiber fermentation.
- Consider a probiotic supplement if you struggle with gut imbalances.
Here are some natural supplements that can help modulate the microbiome for weight loss by promoting gut diversity, reducing inflammation, and improving metabolism:
1. Prebiotics (Fuel for Good Bacteria)
- Inulin – Found in chicory root, asparagus, and onions, it feeds Bifidobacteria, supporting gut health.
- Acacia fiber – A gentle prebiotic that improves microbial diversity and digestion.
- Resistant starch (e.g., green banana flour, potato starch) – Feeds beneficial bacteria and improves insulin sensitivity.
2. Probiotics (Live Beneficial Bacteria)
- Lactobacillus gasseri – Shown to help reduce belly fat and support metabolism.
- Bifidobacterium breve – Supports fat metabolism and gut balance.
- Saccharomyces boulardii – A probiotic yeast that improves digestion and reduces gut inflammation.
3. Polyphenols (Plant Compounds That Feed Gut Bacteria)
- Green tea extract (EGCG) – Supports fat oxidation and gut health.
- Berberine – Regulates blood sugar and promotes a healthy gut microbiome.
- Pomegranate extract – Rich in ellagic acid, which feeds beneficial gut bacteria.
4. Fermented Food-Based Supplements
- Kefir or yogurt capsules – Contain live cultures to improve gut flora.
- Fermented turmeric or ginger – Enhances microbial diversity and reduces inflammation.
In THIS article, you can find detailed information on microbiome modulation.
Conclusion
A diverse gut microbiome, fueled by fiber variety and fermented foods, is a powerful tool for weight management. By nourishing your gut bacteria, you can improve metabolism, regulate appetite, and reduce inflammation—all of which contribute to a healthier body weight. Start incorporating more fiber-rich and fermented foods into your diet today, and let your microbiome work for you!
Gut-Brain Axis, Microbiome and Gut health, Natural medicines
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social interaction, communication, and restricted or repetitive behaviors. While the exact etiology of autism remains elusive, emerging research has highlighted the potential role of the gut microbiome in its pathophysiology. The gut-brain axis, a bidirectional communication system between the gastrointestinal tract and the central nervous system, has become a focal point of investigation. This article delves into the intricate relationship between gut health and autism, with a particular emphasis on the microbiome-neurotransmitter axis, including serotonin production, GABA modulation, and dopamine influence. We will also explore the clinical applications of this research.
The Gut Microbiome and Autism
The gut microbiome is a complex community of trillions of microorganisms, including bacteria, viruses, fungi, and archaea, that reside in the gastrointestinal tract. These microbes play a crucial role in maintaining gut health, modulating the immune system, and influencing brain function through the gut-brain axis. In individuals with autism, alterations in the composition and diversity of the gut microbiome have been consistently observed. These dysbiotic changes may contribute to the gastrointestinal (GI) symptoms commonly reported in autistic individuals, such as constipation, diarrhea, and abdominal pain, as well as the core behavioral symptoms of autism.
Dysbiosis in Autism
Studies have shown that children with autism often have an imbalance in their gut microbiota, characterized by a reduction in beneficial bacteria (e.g., Bifidobacterium and Lactobacillus) and an overgrowth of potentially harmful bacteria (e.g., Clostridium and Desulfovibrio). This dysbiosis may lead to increased intestinal permeability, often referred to as “leaky gut,” which allows harmful substances to enter the bloodstream and potentially affect brain function. The resulting systemic inflammation and immune activation have been proposed as mechanisms linking gut dysbiosis to neurodevelopmental disorders, including autism.
The Microbiome-Neurotransmitter Axis
The gut microbiome plays a pivotal role in the production and modulation of neurotransmitters, which are chemical messengers that facilitate communication between neurons in the brain. The microbiome-neurotransmitter axis is a critical component of the gut-brain axis and may be a key factor in the neurobehavioral symptoms observed in autism. Below, we explore the role of three major neurotransmitters—serotonin, GABA, and dopamine—in the context of autism and gut health.
1. Serotonin Production
Serotonin, often referred to as the “feel-good” neurotransmitter, is crucial for regulating mood, anxiety, and social behavior. Interestingly, approximately 90% of the body’s serotonin is produced in the gut by enterochromaffin cells, with the gut microbiota playing a significant role in its synthesis. Certain gut bacteria, such as Lactobacillus and Bifidobacterium, can influence serotonin levels by modulating the availability of its precursor, tryptophan.
In autism, alterations in serotonin signaling have been well-documented. Some individuals with autism exhibit elevated levels of serotonin in the blood (hyperserotonemia), which may reflect dysregulated serotonin metabolism. Dysbiosis in the gut microbiome could contribute to this dysregulation by affecting the production and breakdown of serotonin. For example, an overgrowth of Clostridium species has been associated with increased serotonin production, potentially leading to hyperserotonemia and contributing to the behavioral symptoms of autism.
2. GABA Modulation
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain and plays a crucial role in regulating neuronal excitability. Imbalances in GABA signaling have been implicated in autism, with some studies suggesting reduced GABAergic activity in autistic individuals. This reduction may contribute to the hyperexcitability and sensory processing difficulties often observed in autism.
The gut microbiome can influence GABA levels through the production of GABA by certain bacteria, such as Lactobacillus and Bifidobacterium. These bacteria can convert glutamate, an excitatory neurotransmitter, into GABA, thereby promoting a balance between excitatory and inhibitory signaling in the brain. Dysbiosis in the gut microbiome may disrupt this balance, leading to altered GABAergic signaling and contributing to the neurobehavioral symptoms of autism.
3. Dopamine Influence
Dopamine is a neurotransmitter involved in reward processing, motivation, and motor control. Dysregulation of dopamine signaling has been implicated in various neuropsychiatric conditions, including autism. Some studies have suggested that autistic individuals may have altered dopamine receptor sensitivity or dysregulated dopamine metabolism.
The gut microbiome can influence dopamine levels through the production of dopamine by certain bacteria, such as Bacillus and Escherichia. Additionally, the gut microbiota can modulate dopamine signaling by affecting the availability of its precursor, tyrosine. Dysbiosis in the gut microbiome may lead to altered dopamine levels, potentially contributing to the reward processing and motor control difficulties observed in autism.
Clinical Applications
The growing understanding of the gut-brain axis and the microbiome-neurotransmitter axis in autism has opened up new avenues for therapeutic interventions. Below, we explore some of the clinical applications of this research, including dietary interventions, probiotics, prebiotics.
1. Dietary Interventions
Dietary interventions, such as the gluten-free, casein-free (GFCF) diet, have been widely explored in the context of autism. These diets are based on the hypothesis that gluten and casein may exacerbate GI symptoms and behavioral issues in autistic individuals by contributing to gut dysbiosis and increased intestinal permeability. While the evidence for the efficacy of GFCF diets is mixed, some studies have reported improvements in GI symptoms and behavioral outcomes in a subset of autistic individuals.
Other dietary interventions, such as the ketogenic diet and the specific carbohydrate diet (SCD), have also been explored for their potential to modulate the gut microbiome and improve symptoms in autism. These diets may promote the growth of beneficial bacteria and reduce inflammation, thereby supporting gut health and brain function.
2. Probiotics and Prebiotics
Probiotics are live microorganisms that confer health benefits when consumed in adequate amounts. Certain probiotic strains have been shown to modulate the gut microbiome, reduce inflammation, and improve GI symptoms in autistic individuals. Probiotics may also influence neurotransmitter production and signaling, potentially leading to improvements in behavioral symptoms.
Prebiotics are non-digestible food components that promote the growth of beneficial bacteria in the gut. By providing a substrate for beneficial bacteria, prebiotics can help restore gut microbial balance and support gut-brain communication. Some studies have suggested that prebiotic supplementation may improve GI symptoms and behavioral outcomes in autistic individuals.
Probiotics
Bacillus subtilis
- Function: A well-researched spore-forming bacterium that has been shown to support gut health by promoting a balanced microbiome, improving digestion, and supporting immune function.
- Mechanism: Bacillus subtilis spores germinate in the intestines and help outcompete harmful microbes, enhancing the growth of beneficial bacteria. It is also known for producing enzymes that aid in digestion.
Bacillus coagulans
- Function: Known for its ability to survive the harsh conditions of the stomach and reach the intestines, Bacillus coagulans has been shown to support gut health by increasing the levels of beneficial bacteria, such as lactobacilli.
- Mechanism: Produces lactic acid, which helps maintain an acidic environment that supports the growth of good bacteria while inhibiting harmful pathogens. It also improves gut barrier function and reduces inflammation.
Bacillus clausii
- Function: This spore-forming bacterium is often used for gastrointestinal issues, including diarrhea and gut imbalances. It has been shown to restore microbial balance by increasing levels of beneficial bacteria while reducing the growth of harmful ones.
- Mechanism: Bacillus clausii supports the restoration of a healthy gut microbiota by stimulating the production of butyrate (a short-chain fatty acid) and enhancing the gut’s defense system.
Lactobacillus rhamnosus
- Function: A well-researched probiotic known for its ability to promote gut health and prevent the overgrowth of harmful bacteria.
- Mechanism: Lactobacillus rhamnosus primarily resides in the large intestine, where it competes with pathogenic bacteria and helps to support a balanced microbiome. It’s less likely to contribute to SIBO because it prefers the lower part of the intestines and produces lactic acid to lower pH, which helps maintain gut balance.
Saccharomyces boulardii
- Function: Saccharomyces boulardii is a beneficial yeast rather than a bacteria, and it’s known for supporting gut health and helping to restore microbiome balance, especially after antibiotic use or digestive issues.
- Mechanism: Unlike bacteria, Saccharomyces boulardii does not colonize the small intestine and instead acts as a transient probiotic. It helps support the gut by promoting the growth of beneficial bacteria, particularly in the colon, and does not typically contribute to SIBO.
Prebiotics (Fibers that Feed Good Bacteria)
- Inulin: Found in foods like chicory root, artichokes, and onions, inulin promotes the growth of beneficial bifidobacteria.
- Fructooligosaccharides (FOS): Found in bananas, garlic, and leeks, FOS helps stimulate beneficial bacteria like Bifidobacterium and Lactobacillus.
- Beta-glucans: Present in oats and barley, these fibers support beneficial bacteria and enhance immune function.
Polyphenols (Plant Compounds with Antioxidant Properties)
- Resveratrol: Found in red wine, grapes, and berries, resveratrol has been shown to support gut bacteria diversity and inhibit harmful bacterial growth.
- Curcumin: The active compound in turmeric, curcumin has anti-inflammatory properties and promotes beneficial gut bacteria.
- Flavonoids: Found in foods like apples, citrus fruits, and onions, flavonoids promote the growth of beneficial bacteria such as Bifidobacteria and Lactobacillus.
4. Targeted Therapies
As our understanding of the microbiome-neurotransmitter axis in autism deepens, there is potential for the development of targeted therapies that modulate specific microbial pathways or neurotransmitter systems. For example, interventions that promote the growth of GABA-producing bacteria or enhance serotonin metabolism may offer new treatment options for autistic individuals with specific neurotransmitter imbalances.
GABA-producing bacteria refer to a group of gut microbiota that can produce gamma-aminobutyric acid (GABA), an important neurotransmitter in the brain. GABA is known for its calming and relaxing effects on the nervous system, promoting a sense of well-being, reducing stress, and improving sleep quality.
In the gut, certain bacteria can convert dietary components into GABA, which can then influence the gut-brain axis—the communication pathway between the gut and the brain. Here’s more about how GABA-producing bacteria work:
Common GABA-Producing Bacteria:
- Lactobacillus species:
- Lactobacillus rhamnosus, Lactobacillus brevis, and Lactobacillus plantarum are known to produce GABA. These strains are commonly found in fermented foods like yogurt, kimchi, and sauerkraut. They play a role in promoting gut health and can have a positive effect on mood and anxiety levels.
- Bifidobacterium species:
- Strains like Bifidobacterium longum are involved in GABA production. Bifidobacteria are also important for gut health and immune function, and some studies suggest they might play a role in influencing behavior through the production of GABA.
- Enterococcus species:
- Enterococcus faecium and other Enterococcus strains are also capable of producing GABA. These bacteria are naturally present in the human gut and can influence mood and stress levels through their metabolic activities.
- Streptococcus species:
- Some strains of Streptococcus, such as Streptococcus thermophilus, have also been shown to produce GABA. These bacteria are often used in dairy fermentation and may have neuroactive properties.
How GABA-Producing Bacteria Influence the Microbiome and Brain:
- Gut-Brain Axis: The production of GABA by these bacteria can affect the gut-brain axis, which is the direct communication between the gut and the central nervous system. GABA, being a neurotransmitter, can modulate brain activity, reducing stress and anxiety. This means that the gut microbiota plays an important role in mental health, influencing mood and cognitive function.
- Stress Reduction: The GABA produced by these bacteria may bind to GABA receptors in the gut and brain, helping to reduce the activity of the sympathetic nervous system (the “fight or flight” response) and promoting a state of relaxation.
- Mental Health: A balanced gut microbiome with adequate GABA production is thought to contribute to a better overall mental state, potentially reducing symptoms of anxiety, depression, and insomnia.
GABA-producing bacteria play a crucial role in modulating the gut-brain axis and may have beneficial effects on mental health by influencing the production of GABA, a neurotransmitter known for its calming effects. The consumption of foods or supplements containing these probiotic strains could potentially enhance GABA levels and support relaxation and stress reduction.
Other natural compounds that can help with producing GABA:
There are several natural compounds that can help with GABA production in the body or enhance its activity. These compounds may work in different ways, such as promoting the synthesis of GABA or increasing its availability in the brain. Here are some natural options that may help:
Magnesium
- Mechanism: Magnesium is involved in the activation of the GABA receptor, which can help enhance its calming and relaxing effects on the nervous system. Magnesium also supports the enzymes that are needed for GABA synthesis.
- Sources: Magnesium-rich foods include leafy greens, nuts, seeds, whole grains, and legumes. Magnesium supplements are also widely available.
L-Theanine
- Mechanism: L-Theanine, an amino acid found primarily in green tea, can help increase GABA levels, along with other calming neurotransmitters like serotonin and dopamine. It is known to promote relaxation without causing drowsiness.
- Sources: Green tea, matcha, and L-theanine supplements are common sources.
Taurine
- Mechanism: Taurine is an amino acid that has been shown to have a GABA-like effect. It can help activate GABA receptors and increase GABA synthesis in the brain.
- Sources: Taurine is found in animal-based foods like meat, fish, and dairy. It can also be taken as a supplement.
Valerian Root
- Mechanism: Valerian root is a well-known herbal remedy that has been shown to increase GABA activity in the brain. It is often used as a sleep aid and has calming properties.
- Sources: Valerian root is available in capsule, tablet, or tea form.
Ashwagandha
- Mechanism: Ashwagandha, an adaptogenic herb, has been shown to enhance GABA receptor activity and help reduce stress and anxiety. It can have a calming effect on the nervous system and help improve sleep quality.
- Sources: Ashwagandha is available as a powder, capsule, or extract.
Kava Kava
- Mechanism: Kava kava has GABAergic effects, meaning it can enhance GABA receptor binding, leading to relaxation and reduced anxiety. It has been traditionally used in Pacific Island cultures for its calming and stress-relieving properties.
- Sources: Kava is typically consumed as a root powder, capsules, or tea.
L-Glutamine
- Mechanism: L-Glutamine is an amino acid that can be converted into GABA in the brain. By increasing glutamine levels, it supports the production of GABA.
- Sources: L-glutamine is found in foods like meat, fish, eggs, and dairy, as well as in supplement form.
Vitamin B6 (Pyridoxine)
- Mechanism: Vitamin B6 is essential for the production of GABA. It acts as a coenzyme for the enzyme glutamate decarboxylase, which converts glutamate (an excitatory neurotransmitter) into GABA (an inhibitory neurotransmitter).
- Sources: Vitamin B6 is found in foods like poultry, fish, bananas, avocados, potatoes, and fortified cereals.
Zinc
- Mechanism: Zinc plays a role in GABA receptor function. It has been shown to enhance the effects of GABA in the brain and is important for neurotransmitter balance.
- Sources: Zinc is found in foods like shellfish, meat, seeds, nuts, and legumes. It is also available in supplement form.
Turmeric (Curcumin)
- Mechanism: Curcumin, the active compound in turmeric, has been found to enhance the activity of GABA receptors in the brain. It may also help reduce oxidative stress and inflammation, which can affect GABA production.
- Sources: Curcumin is available in turmeric powder, capsules, and extracts.
Conclusion
The gut microbiome plays a crucial role in maintaining gut health and influencing brain function through the gut-brain axis. In autism, dysbiosis in the gut microbiome may contribute to both GI symptoms and neurobehavioral symptoms by affecting the production and modulation of key neurotransmitters, such as serotonin, GABA, and dopamine. The microbiome-neurotransmitter axis represents a promising target for therapeutic interventions, including dietary interventions, probiotics, prebiotics, and fecal microbiota transplantation.
While the field is still in its early stages, the growing body of research on gut health in autism offers hope for new and effective treatments that address the underlying biological mechanisms of the condition. By targeting the gut microbiome and its influence on neurotransmitter systems, we may be able to improve the quality of life for individuals with autism and their families. Future research should focus on elucidating the specific microbial and neurotransmitter pathways involved in autism, as well as the development of personalized therapies that take into account the unique gut microbiome profile of each individual.
Gut-Brain Axis, Microbiome and Gut health
The human digestive system is home to trillions of microorganisms that play crucial roles in our overall health. Understanding the delicate balance of gut bacteria and making informed decisions about probiotic supplementation is essential for optimal digestive health and nutrient absorption.
The Importance of Gut Microbiome Balance
Natural Gut Flora
The digestive system naturally hosts a complex ecosystem of microorganisms, including:
- Beneficial bacteria
- Yeasts
- Other microorganisms that support digestion
- Immune system function
Role in Nutrient Absorption
Proper bacterial balance is crucial for:
- Breaking down complex nutrients
- Synthesizing certain vitamins
- Maintaining gut barrier integrity
- Supporting immune function
Understanding Small Intestinal Bacterial Overgrowth (SIBO)
What is SIBO?
Small Intestinal Bacterial Overgrowth occurs when bacteria that normally reside in the large intestine migrate and proliferate in the small intestine, where bacterial populations should be minimal.
SIBO Complications
Excessive bacterial growth in the small intestine can lead to:
- Nutrient malabsorption
- Bloating and discomfort
- Inflammation
- Compromised gut barrier function
Probiotic Supplementation: A Double-Edged Sword
Timing and Selection
It is crucial to approach probiotic supplementation with careful consideration:
- Probiotics should typically be taken after completing antibiotic treatment
- Selection should be based on documented deficiencies through intestinal microbiome testing
- Random probiotic supplementation can be ineffective or potentially harmful
Risks of Improper Supplementation
Traditional probiotics may exacerbate certain conditions:
- Lactobacillus and Bifidobacterium species can multiply in the small intestine
- Excessive growth of even beneficial bacteria can contribute to SIBO
- Indiscriminate probiotic use may worsen existing gut imbalances
Using an inappropriate probiotic may not have any positive effects and could even harm you. Overgrowth of beneficial bacteria can lead to SIBO (Small Intestinal Bacterial Overgrowth). Lactobacillus and bifidobacterium species are commonly found in probiotics, but these bacteria can multiply in the small intestine, where they shouldn’t reside. Since most probiotics contain these strains, taking them while dealing with SIBO can worsen the condition, essentially fueling the problem.
It’s essential to understand the composition of your intestinal flora before choosing a probiotic. To reduce SIBO symptoms, soil-based probiotics are recommended. These innovative bacterial strains produce bioavailable antioxidants and riboflavin at the absorption site, supporting digestive health.
Soil-based probiotics are particularly beneficial because they don’t aggravate SIBO symptoms. Unlike other probiotics, they don’t colonize or feed bacteria in the small intestine. Instead, they multiply in the colon, which helps support overall gut health. Additionally, soil-based probiotics are known to produce riboflavin (vitamin B2), a vital nutrient that supports the digestive system and aids in the proper absorption of nutrients, further promoting gut health without worsening SIBO.
The Innovation of Soil-Based Probiotics
Advantages of Soil-Based Organisms (SBOs)
Soil-based probiotics offer unique benefits:
- Production of bioavailable antioxidants
- Generation of riboflavin at absorption sites
- Natural transit through the small intestine
- Proper colonization in the large intestine
Riboflavin Production
Riboflavin’s importance in digestive health:
- Essential nutrient for digestive system maintenance
- Supports cellular energy production
- Aids in nutrient metabolism
- Contributes to gut barrier integrity
Colonization Patterns
Soil-based probiotics demonstrate superior colonization characteristics:
- Do not colonize the small intestine
- Begin multiplication in the colon
- Avoid contributing to SIBO
- Support natural gut flora balance
Best Practices for Probiotic Implementation
Assessment and Testing
Before starting probiotics:
- Conduct comprehensive intestinal microbiome testing
- Identify specific bacterial deficiencies
- Consider current gut health status
- Consult with healthcare professionals
Monitoring and Adjustment
During probiotic supplementation:
- Track symptom changes
- Adjust dosage as needed
- Monitor for adverse reactions
- Regular reassessment of gut health
Clinical Considerations
Patient-Specific Approaches
Treatment should be tailored to individual needs:
- Consider existing health conditions
- Account for medication interactions
- Evaluate lifestyle factors
- Assess dietary patterns
Integration with Other Treatments
Probiotic therapy should be part of a comprehensive approach:
- Dietary modifications
- Stress management
- Lifestyle adjustments
- Other therapeutic interventions as needed
Conclusion
Restoring and maintaining optimal gut health requires a sophisticated understanding of the microbiome and careful selection of probiotic supplements. Soil-based probiotics represent an innovative approach for supporting digestive health, particularly in cases of SIBO or other gut imbalances. However, success depends on proper testing, selection, and implementation of probiotic therapy as part of a comprehensive treatment strategy.
References
- Quigley EMM. (2019). Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet? Nature Reviews Gastroenterology & Hepatology, 14(5), 315-320.
- Sanders ME, et al. (2019). Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nature Reviews Gastroenterology & Hepatology, 16(10), 605-616.
- Leblhuber F, et al. (2018). Probiotics in the Treatment of Depression: Science or Fiction? Nutrients, 10(6), 752.
- Zmora N, et al. (2018). Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features. Cell, 174(6), 1388-1405.
- Rao SSC, et al. (2018). Small Intestinal Bacterial Overgrowth: Clinical Features and Therapeutic Management. Clinical Gastroenterology and Hepatology, 16(6), 823-832.
