Berberine for diarrhea

Berberine for diarrhea

Gut-Brain Axis, Health, Microbiome and Gut health, Natural medicines

berberine

Studies have confirmed that the bacteriostatic effect of BERBERINE plays a role in improving SIBO symptoms; berberine lowers blood sugar, reduces blood fat, and improves arrhythmias, and cardiovascular disease, reducing the risk and preventing cancer.

 

 

 

Berberine optimizes blood sugar, plays a role in reducing blood fat, reduces the risk of cardiovascular disease, and last but not least, relieves diarrheal symptoms due to its bacteriostatic effect and can be used effectively with SIBO.

Berberine, the herbal agent for diarrhea

Berberin is a herbal agent for diarrhea, but you should be careful because, like antibiotics, Berberine kills good bacteria as well.

 

Physiological effects of berberine 

  • Insulin resistance often develops as a result of intestinal problems. Berberin’s blood sugar optimizing effect prevents the development of insulin resistance and reverses existing insulin resistance, and promotes weight loss
  • It inhibits the growth of pathogens that cause diarrhea, thereby relieving the symptoms of diarrhea. It can be a great help in case of intestinal inflammation problems, even in SIBO (Small Intestine Bacterial Overgrowth) This natural herbal active ingredient, an alkaloid, can effectively control blood sugar levels – even insulin resistance. Studies have confirmed that the bacteriostatic effect of berberine plays a role in lowering blood sugar, reducing blood fat, improving arrhythmias, and cardiovascular disease, reducing the risk, and preventing cancer. Of these, the effectiveness of reducing blood sugar and blood lipids has been clinically proven by Chinese researchers.
  • Berberin also can effectively reduce the risk of cancer.
  • Research shows that it has a beneficial effect on cholesterol levels by activating the enzyme protein kinase (AMPK), which regulates the metabolism of fats and carbohydrates, and increases the response to the insulin produced by the pancreas

Other physiological effects

  • Accelerate wound healing
  • Weight loss
  • Mild sedation
  • Kidney protection
  • Protection against harmful radiation
  • Muscle relaxation 
  • Antihypertensive effect
  • Supports cardiovascular function
  • Prevention of gastric ulcer
  • It has an antioxidant effect and lowers cholesterol It has an anti-inflammatory effect and a fungicidal effect It is also effective in preventing or alleviating diarrhea. Berberine is able to fight pathogenic microorganisms and inhibit various bacteria, such as dysentery bacteria
Resources

  • Studies on the effect of Berberine

    SIBO/IBS

    https://pubmed.ncbi.nlm.nih.gov/26400188/
    https://the-unwinder.com/reviews/berberine-for-sibo/

    Weigt loss

    https://www.sciencedirect.com/science/article/pii/S0753332220303292

    Diabetes Type 2

    https://www.everydayhealth.com/type-2-diabetes/potential-benefits-berberine-type-2-diabetes/
    https://www.everydayhealth.com/type-2-diabetes/potential-benefits-berberine-type-2-diabetes/

    Cholesterol

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871262/
    https://pubmed.ncbi.nlm.nih.gov/15926873/
    https://www.verywellhealth.com/berberine-lowers-cholesterol-698106
    https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05028-8

    PCOS

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028834/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261244/
    https://www.hindawi.com/journals/ecam/2019/7918631/
    https://www.clinicaltrials.gov/ct2/show/NCT01138930

The glutathione precursor

The glutathione precursor

Autism and Genes, Detoxification, Health, Microbiome and Gut health

N-Acetyl-L-Cysteine (NAC) is one of the most exciting antioxidant amino acids of our time. An anti-inflammatory agent, one of the precursors to glutathione, which referred to as a master antioxidant (1). That is why we recommend the combined use of our NAC and Glutathione products.

The mucolytic, antitussive effect of NAC has long been known in the health circles because of its ability to break down disulfide bridges in mucus and secretions (1).

New research has highlighted other important aspects: its effects on stabilizing blood sugar levels (2) (insulin resistance, adjusting blood fat levels), increasing fertility and protecting the nervous system have innovative potential.

N-Acetyl Cystein the glutathione precursor

“The glutathione precursor” what does it mean? Glutathione, also known as GSH, is a molecule found naturally in your body. It is produced by the liver and nerve cells in the central nervous system. Glutathione is made up of three amino acids: L-cysteine, glycine, and L-glutamate.
Glutathione is an antioxidant, a molecule that helps fight free radicals. When more free radicals exist than antioxidants, oxidative cell damage occurs. This can lead to inflammation and a variety of health issues.
In addition to being an antioxidant,

Acetyl-L-Cysteine (NAC) is one of the most exciting antioxidant amino acids of our time. An anti-inflammatory agent, one of the precursors to glutathione, which referred to as a master antioxidant [1].

A Powerful Antioxidant

N-acetylcysteine, derived from the simple amino acid cysteine, provides significant protection against a broad array of modern toxins. 

NAC is a precursor of glutathione. Glutathione is the body’s most important antioxidant, found in every single cell. It is also called a “master antioxidant” because it exerts its effects within cells and its unique ability to maximize the effects of all other antioxidants, including vitamins C and E, Q + Ubiquinol, r-alpha-lipoic acid.

The primary function of Glutathione is to protect cells and mitochondria from the damaging, destructive effects of internal oxidation processes (2). It protects the integrity of our cells, tissues and organs, thus playing an important role in the fight against chronic diseases associated with aging. Glutathione is key to detoxification, neutralizing toxins in the body, protecting against the harmful effects of radiation, chemicals and environmental contaminants.

It improves the functioning of the immune system, has a nervous system protection effect, increases the body’s resistance to infections, can speed up the recovery from diseases, and increases the body’s energy levels and vitality (3).

For a healthy immune system

Glutathione plays an important role in maintaining the healthy functioning of the immune system. Oxidative stress caused by viral infections causes inflammation in the cells and glutathione levels are demonstrably reduced.

Decreased immunity and an increased risk of infections are associated with low glutathione levels (4). Glutathione is beneficial in increasing the number of T cells in immune leukocytes and NK cells in natural killer cells (5). Glutathione deficiency can be detected in autoimmune diseases.

Research has shown that glutathione has a positive effect on the normal functioning of the immune system and prevents the development of an excessive immune response and inflammation in autoimmune diseases (6).

Liver protection, detoxification

Glutathione is found in the highest concentrations in the liver and kidneys. The liver plays a prominent role in the II. in phase detoxification processes (7). Helps remove toxins, foreign chemicals, potential carcinogens, hormones, pollutants.

It converts them into water-soluble substances that can now be easily excreted from the body through the kidneys. Glutathione is also present in the entire intestinal mucosa, where it captures and neutralizes potential toxins before they are absorbed into the body. Glutathione protects the intestinal wall, which, if weakened, can lead to a leaking / permeable intestinal problem (8).

The detoxification ability of glutathione can be further enhanced by other sulfur-containing molecules: cruciferous plants (broccoli), r-alpha-lipoic acid, N-acetyl cysteine, turmeric, St. John’s wort and B vitamins, selenium, and the like. 

Excessive consumption of over-the-counter drugs containing paracetamol (eg, antipyretics, analgesics, etc.) can lead to hepatotoxicity and deplete the body’s glutathione system. NAC is able to rehabilitate toxic processes in liver cells.

Acetyl-L-Cysteine increases the body’s glutathione levels, enhances the immune system through its antioxidant effect, helps cellular regeneration and reduce inflammation, and contributes to the effective elimination of toxins and toxins.

It contributes to the multi-level detoxification processes of the liver, and also promotes the rehabilitation of liver cells in the state of fatty liver. In this case, Choline and Inositol can help in the detoxification process.

Protecting the brain and nervous system

Our brain uses a lot of oxygen and is therefore extremely vulnerable to oxidative damage. This oxidative damage adversely affects neurological functions and our development, which can lead to mitochondrial dysfunction and a number of neurodegenerative diseases. Glutathione protects brain cells against odiation.

Low glutathione levels increase the risk of developing neurodegenerative diseases. Heavy metals that accumulate in the brain can cause severe oxidative stress and cell damage. Glutathione has the ability to detoxify toxic metals in the brain, thereby protecting the health of the nervous system (9).

Energy production of cells, enhancement of vitality

Mitochondria are responsible for the energy production of our cells in the form of adenosine triphosphate (ATP). The function of mitochondria also plays a vital role in cell health, intercellular communication, regulated cell death, and cell growth.

Researchers today believe that mitochondrial health is directly linked to our aging processes and the resistance of cells to degenerative diseases. Glutathione has the potential to improve mitochondrial health and directly affect our energy-producing abilities.

By-products of cellular metabolism are also free radicals that are destructive. They are also able to neutralize glutathione (10).

NAC in relation to the hormonal system and fertility

Research results support its effectiveness in reducing ROS (reactive oxygen species) levels, combined with vitamins A, E and Omega-3 fatty acids. Other literature has also described the combination of NAC and selenium as effective (11). High ROS levels presuppose inflammation and affect the DNA of sperm.

It supports the ovarian cycle, i.e. the cycle of ovulation, thereby positively affecting fertility (12). By stimulating glutathione levels, it has a positive effect on insulin secretion and increases insulin sensitivity, so it can be used as an adjunct in the treatment of insulin-resistant conditions in polycystic ovary syndrome, which is closely related to insulin resistance (13).

Furthermore, a human study highlights the effect of NAC on cysts that cure-like use of NAC may reduce the potential for cysts due to endometriosis (14). In such cases, I strongly recommend Glutathione, Choline + Inositol.

The role of NAC in the functioning of the respiratory system

As a mutolytic, Acetyl-L-Cysteine ​​supports the emptying of difficult-to-break secretions and can therefore help with prolonged, persistent coughs (colds, flu, bronchitis (15).

Research has been shown to be effective in the adjunctive treatment of COPD [8]. Due to its powerful antioxidant effect, it can reduce the condition of chronic inflammation. According to the research, Acetyl-L-Cysteine ​​intake promoted physical activity and performance in patients with COPD.

By increasing glutathione levels, it can reduce the inflammatory state of lung tissue and contribute to its regeneration.

What else does NAC help

  • To clean the lungs of the secretion due to smoking.
  • In the adjunctive treatment of COPD
  • Prevention of respiratory infections, alleviation of pre-existing symptoms (persistent cough)
  • Endometriosis, in the adjunctive treatment of PCOs for fertility problems (both women and men)
  • In post-contraceptive rehabilitation (in such cases we also recommend our Broccoli & Watercress, Choline & Inositol products)
  • To detoxify the liver, regenerate liver cells, lower triglycerides In case of blood sugar and insulin homeostasis problems, in the adjunctive treatment of insulin resistance
  • Nervous system, to support nerve cells and to increase memory
  • Metabolism of toxins and cancer-causing substances
  • Natural creation and repair of DNA
  • Production of protein and prostaglandin, a compound with hormone-like effects
  • Activation of enzymes
  • Glutathione also helps with the breakdown of nutrients and the regulation of important body processes, such as the immune response.
  • A small study published in Medical Science Monitor in 2011 shows a connection between low glutathione levels and autism spectrum disorders.
  • The mucolytic, antitussive effect of NAC has long been known in the health circles because of its ability to break down disulfide bridges in mucus and secretions .
  • It is also used as an antidote in problems with paracetamol overdose to protect liver cells.
  • New research has highlighted other important aspects: its effects on stabilizing blood sugar levels (insulin resistance, adjusting blood fat levels), increasing fertility and protecting the nervous system have innovative potential.
  • N-acetylcysteine (NAC) is effective both in inhibiting biofilm formation and in destroying developed biofilms. (12)
Resources
  • [1] Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio F. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018 Jul;52(7):751-762
  • [2] Samuni Y, Goldstein S, Dean OM, Berk M. The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta. 2013 Aug;1830(8):4117-29.
  • [3] Fulghesu AM, Ciampelli M, Muzj G, et al. N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril. 2002 Jun;77(6):1128-35.
  • [4] Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009 Feb;181(2):741-51.
  • [5] Badawy A, State O, Abdelgawad S. N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial. Acta Obstet Gynecol Scand. 2007;86(2):218-22.
  • [6] Porpora MG, Brunelli R, Costa G, Imperiale L, Krasnowska EK, Lundeberg T, Nofroni I, Piccioni MG, Pittaluga E, Ticino A, Parasassi T. A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine. Evid Based Complement Alternat Med. 2013;2013:240702.
  • [7] Stey C, Steurer J, Bachmann S, Medici TC, Tramèr MR. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J. 2000 Aug;16(2):253-62.
  • [8] Stav D, Raz M. Effect of N-acetyl cysteine on air trapping in COPD: a randomized placebo-controlled study. Chest. 2009 Aug;136(2):381-6.
  • [9] Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A. A Review on Various Uses of N-Acetyl Cysteine. Cell J. 2017;19(1):11-17. doi:10.22074/cellj.2016.4872
  • [10] Sandhir R, Sood A, Mehrotra A, Kamboj SS. N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington’s disease. Neurodegener Dis. 2012;9(3):145-57.
  • [11] Shungu DC. N-acetylcysteine for the treatment of glutathione deficiency and oxidative stress in schizophrenia. Biol Psychiatry. 2012 Jun 1;71(11):937-8.
  • [12] https://pubmed.ncbi.nlm.nih.gov/25339490/

Treatment of histamine intolerance

Treatment of histamine intolerance

Histamine intolerance and MCAS, Methylation

Treatment of Histamine intolerance

Histamine intolerance occurs when histamines, chemicals released by the body in response to allergens, build up in the body and have a negative impact on health and well-being.

People with Histamine intolerance may experience symptoms such as headaches, nausea, digestive issues, rashes and more if they consume foods with high histamine content or aren’t able to break down histamines efficiently.

However, there are treatment options that can help alleviate symptoms and even heal Histamine intolerance over time. 

First steps in the treatment of histamine intolerance

There are very effective natural solutions for histamine Intolerance and Mast cell activation syndrome that can be added to the medical treatment or can be used alone. In the treatment of histamine intolerance and mast cell activation syndrome, if we think of natural substances, the same can be said, i.e. the goal is to reduce the amount of histamine in the body, so it is worth controlling the process of histamine breakdown and stabilizing mast cells. 

I did not take the natural treatment of histamine intolerance and MCAS separately because, like the symptoms, the proper natural active ingredients are similar too. However, the treatment of MCAS is a very complex thing. In many cases, when the immune system has calmed down, the asymptomatic stage can be maintained only by taking natural remedies. In histamine intolerance, with the help of natural supplements, you can become asymptomatic in the long run if the root cause is treated.

First of all, the cause of both histamine intolerance and mast cell activation syndrome should be explored. In the case of histamine intolerance, the first thing to think about is the inflammatory condition of the intestinal tract. I have described the causes in previous articles. Read them here: HIT  , MCAS

There is often a problem that the therapy used to eliminate the root causes is not tolerated by the individual. This is a major challenge for all diseases, especially MCAS. If you have severe histamine intolerance or MCAS, you may have severe symptoms of the medication you are taking for the root cause (such as parasites, lyme, SIBO, retroviruses, or molds).

The reaction is individual for everyone. It is also advisable to consult a specialist regarding natural active substances, who are experts in the natural treatment of these health conditions. However, it is a fact that certain substances can be used safely. It is worth switching the substances if possible and observing which is the most suitable active ingredient for you.

Based on the above, both Histamine intolerance and mast cell activation syndrome should be treated along the following 4 pillars*

1. Low histamine diet: Minimize your intake of histamine through food

2. Helping to breakdown histamine

3. Stabilization of mast cells

4. Stabilising the immune system and reducing inflammation

Here are the natural options that are best suited for treating histamine or mast cell activation problems.

1. Low histamine diet

To reduce histamine levels in your body, you should adopt a low histamine diet. Avoid the following:

Alcohol
Smoked and cured meat
Seafood
Pickled foods
Fermented foods
Leftovers
Canned sh or meat
Berries, especially strawberries (except blueberry)
Preservatives
Vinegar
Try to eat foods as fresh as possible, and stick to anti-inflammatory professional foods. See Low histamine food list

2. Helping to breakdown histamine

Diamine oxidase (DAO) stabilizes mast cells, but more importantly, it is the predominant enzyme besides HNMT enzyme that breaks down histamine. To increase your DAO levels, you can take DAO enzymes. You can also increase your DAO levels with high doses of vitamin C.
You should also avoid anything that blocks the release of DAO. Alcohol is in the first place in blocking the DAO. The worst thing happens when you drink alcohol, histamine is released from your mast cells, and DAO is simultaneously inhibited.

3. Stabilization of mast cells

If you would try any kind of natural supplement, I recommend the following:
Only pure and well-trusted formulations should be chosen. I have tried many kinds of natural supplements. It happened once that I had such intense diarrhea after taking that supplement that I needed to rebuild my gut flora from the beginning again.

I recommend a 3-day trial period with a lower dose of the new supplement before increasing the daily dose or the next supplement. My favorite supplement for stabilizing histamine release is Quercetin. If you want to know everything about the possible treatment, you will have the chance to get all the information on our membership site soon. Check back later.

Resources
  • m B-R, SeoH-S, Ku J-M, et al. Silibinininhibits the production of pro-inflammatory cytokines through inhibition of NF-κB signaling pathway in HMC-1 human mast-cells. Inflammation. Research. 2013;62(11):941-950. doi:10.1007/s00011-013-0640-1.
  • ChapowalA. PetasitesStudy Group. Randomisedcontrolled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324:144-6.
  • Hayes, N. A. and Foreman, J. C. The activity of compounds extracted from feverfew on histamine release from rat mast-cells. J Pharm Pharmacol1987;39(6):466-470
  • Hsieh et al. Baicalein inhibits IL-1ß- and TNF-a-induced inflammatory cytokine production from human mast-cells via regulation of the NF-?B pathway. ClinMolAllergy. 5: 5. 2007.
  • TheoharidesTC, Patra P, Boucher W, et al. Chondroitin sulphateinhibits connective tissue mast-cells. British Journal of Pharmacology. 2000;131(6):1039-1049. doi:10.1038/ sj.bjp.0703672.
  • Ro JY, Lee BC, Kim JY, et al. Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast-cells activated with specific antigenantibodyreactions. J PharmacolExpTher. 2000;292:114–121. 73.
  • https://www.ncbi.nlm.nih.gov/pubmed/24477254
  • https://www.ncbi.nlm.nih.gov/pubmed/28458279
  • https://www.ncbi.nlm.nih.gov/pubmed/9421440
  • https://www.ncbi.nlm.nih.gov/pubmed/10344773
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315779/
Gut Microbiome test

Gut Microbiome test

Autism and Genes, Gut-Brain Axis, Health, Microbiome and Gut health

A gut microbiome test is needed if any kind of abdominal, neurological, or skin complaint is present. It gives relevant information on gut health.

 

 

 

Research shows that your gastrointestinal (GI) system state (or your “gut”) influences your overall health.

While certain symptoms, such as indigestion, mood changes, and skin diseases, could point to imbalances in the gut, these exact connections can only be understood through testing.

This is where microbiome testing could potentially play a role.

A gut microbiome test is a new diagnostic way to get a picture of your overall health.

Microbiome testing measures the amount and types of microbes in your gut, such as bacteria and viruses, via a stool sample. While such tests may be conducted in a doctor’s office, there are at-home tests too when you have to complete the microbiome testing kits on your own.

A gut microbiome refers to the microbes that exist in your digestive system. The intestines, stomach, colon, and esophagus are all important members of your GI tract, and they all contain microbes that affect the digestion process.

Composition of the gut microbiome

You probably know that billions of microorganisms live in our bodies, mostly located in the gastrointestinal tract.  The human genome consists of about 23,000 genes, whereas our microbiome encodes over 3 million genes that produce thousands of metabolites. This means that in the human body there is a superorganism that plays an important role.

Everyone has a unique microbiota like a personal fingerprint and this means that gut microbiota composition is mostly unique to each individual, like an individual identity card.

Current evidence points mostly towards that humans live in a sterile environment in the womb and infants only start being colonized by microbes when going through the vaginal passage, or during skin contact with parents or the medical team. The human microbiota is established in this phase and starts as a dynamic ecosystem that stabilizes during the first 2–3 years.

 

Composition is influenced by:

  • Feeding methods (breast milk, artificial milk, and introduction of solid food);
  • Medication (antibiotics, acid suppressants, drugs);
  • Dietary habits; environment and lifestyle; and weight gain.
  • Genetics factors;
  • Anatomical parts of the intestinal tract (e.g. the large intestine has a higher microbial diversity compared with the small intestine);
  • Gestational age (preterm or full-term birth); delivery mode (vaginal delivery or C-section); and aging.
    The microbiomes have many essential functions in the body: from helping digestion and producing vitamins to supporting the development of the immune system and preventing infections.
  • Impressively there are also interactions between gut microbes and the brain which means we may be able to support mental health by changing the gut microbiome.
  • The microbiome functions as an extra organ, that uses nutrients from ingested foods to produce a large number of compounds, including vitamins, short chain fatty acids (SCFAs), and essential amino acids. The gut microbiome, through metabolite production and fermentation, helps the intestine to maintain its equilibrium. When a balanced interaction between the gastrointestinal (GI) tract and the resident microbiota is disrupted, intestinal and extra-intestinal diseases may develop.
When there’s an imbalance of gut microbes, various health effects may occur as a result. Common symptoms of gut disruptions may include bloating, stool changes, and heartburn,diarrhea,mood swings,skin disorders such as eczema,POD ( peioralis dermatitis)and rashes on any part of the body, SIBO, inflammation, insuline resistance…and so on.

Furthermore
Your gut health affects your brain through neurotransmitters (serotonin contributes to feelings of happiness, gaba – gamma- aminobutyric reduces anxiety ) and these neurotransmitters are produced by gut cells and gut microbes.

Why test your microbiome?

The primary purpose of this type of stool testing is to analyze microbes and potential imbalances in your GI system. This kind of stool sample analysis can provide clues to potential inflammatory conditions or autoimmune diseases, such as inflammatory bowel disease (IBD) and Celiac disease.
By testing your gut microbiome, you can learn more about the functions of your gut microbiome and check that it is helping to keep you healthy and not contributing to making you sick. Using a metagenomic gut microbiome test, you will learn your potential to break down nutrients and discover the potential of your gut microbiome to break down macronutrients such as fiber, protein, simple sugars, and fats.
obtain a comprehensive list of the microbial species present
Whether it’s a well-known species or newly discovered, you will get a full list of the different bacteria and archaea present in your gut.

Receive tailored guidance from a Microbiome Coach

If the detailed information about the result of your microbiome test is not enough for you, it is possible to ask for help from a Microbiome coach who helps in evaluating your test result. Gain a deeper understanding of your Insight™ report and discuss your personalized shopping list of food suggestions with a qualified health professional.

Resources
  • [1] https://pubmed.ncbi.nlm.nih.gov/28743984/
  • [2] https://pubmed.ncbi.nlm.nih.gov/30025401/
  • [3] https://pubmed.ncbi.nlm.nih.gov/27812084/
  • [4] https://pubmed.ncbi.nlm.nih.gov/28512250/
  • [5] Thriene K. et al. Effects of Fermented Vegetable Consumption on Human Gut Microbiome Diversity—A Pilot Study. Fermentation. ;8(3).(2022).
  • [6] Sarka A et al. Pychobiotucs and the Manipulation of Bacteria-Gut-Brain Signlas. Trends in Neurosciences. (2016).
  • [7] Bear T et al. The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress. Microorganisms. (2021)
  • [8] Miranda-Comas G. et al. Implications of the Gut Microbiome in Sports. Sports Health (2022).
  • [9] Day AW. et al. Gut Microbiome Dysbiosis in Alcoholism: Consequences for Health and Recovery. (2022).
  • [10] Leclercq S. et al. Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms. Transl Psychiatry. ;11(1):503. (2021).
  • [11] Seo B et al. Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice. Cell host & microbe. ;27(1):25-40.e6. (2020).
  • [12] Flikkema J. The Relationship Between the Gut Microbiome and Sleep Examined Through Associated Human Disease. University Honors Theses. (2022).
  • [13] Han M. et al.. The interplay between sleep and gut microbiota. Brain Research Bulletin. (2022).
Foods in SIBO

Foods in SIBO

Gut-Brain Axis, Health, Microbiome and Gut health, SIBO

In the next “Foods in SIBO” list, you can find all kinds of food you can eat if you are struggling with SIBO, but you can also use this list if you have abdominal discomfort or IBS.

If you have SIBO, avoiding carbohydrates from your diet is essential. SCD, LFD, GAPS, and FODMAP diets and their variants are the most popular diets recommended to people struggling with SIBO.

All these diets are based on low carbohydrate intake because this feeds pathogens.

The only carbohydrate that bacteria do not eat much of is insoluble fiber. Below you can find most of the food consumed if you have SIBO.

“Foods in SIBO” list

If you have SIBO, you should avoid any carbohydrates. In the “Foods in SIBO” list, you can find all the food that can be consumed

Quality Protein Sources

  • Bone soup
  • Eggs (quail eggs only)
  • Pumpkin seed
  • Organic grass-fed lamb
  • Organic pasture poultry (chicken, duck, turkey)
  • Hydrolyzed bovine collagen
  • Vegan protein: rice, hemp, pea, etc.

Healthy Fats

  • Coconut, coconut oil, coconut flour, coconut + butter / semolina / milk / yogurt / cream
  • Ghee (if you tolerate)
  • Grape seed oil
  • Olive oil
  • Flaxseed oil

Alternatives for diary products

  • Coconut milk, yogurt, cream
  • Oat milk
  • Rice milk
sibo food coconut

Bio, Non-Starch Vegetable

  • Sprouts (including broccoli, radishes and sunflower sprouts)
  • Artichoke
  • Asparagus
  • Bean sprouts
  • Broccoli
  • Brussels sprouts
  • Cabbage
  • Cauliflower
  • Celery
  • Cucumber
  • Fennel
  • Onions
  • Green onions
  • Turnips
  • Herbs (parsley, coriander, basil, rosemary, thyme, dill, lemongrass, etc.)
  • Kohlrabi
  • Leek
  • Salad (baby salad, iceberg lettuce)
  • Peppers (green, red, yellow, orange jalapeno)
  • Radish
  • Rhubarb
  • Onions
  • Swiss chard
  • Watercress
  • Zucchini

sibo food broccoli

Delicious spices

  • Anise
  • Basil
  • Bay leaf
  • Cocoa beans
  • Cayenne
  • Coriander / coriander
  • Cinnamon
  • Clove
  • Cumin
  • Dill
  • Ginger
  • Ground black pepper
  • Mint
  • Nutmeg
  • Oregano
  • Paprika
  • Parsley
  • Red chili flakes
  • Rosemary
  • Sea salt
  • Stevia
  • Tarragon
  • Thyme
  • Curcuma
  • Vanilla
sibo food spices

Drinks

  • Bone soup
  • Coconut milk
  • Smoothies
  • Tea, herbal, decaffeinated
  • Water

Gluten-Free Flour

  • Arrow root starch
  • Coconut flour
  • Sweet potato flour
  • Tapioca flour

Bone soup

Fruits

  • Apples
  • Apricots
  • Blueberries
  • Blackberries
  • Redcurrant
  • Cherry
  • Cranberries
  • Figs
  • Goji berries
  • Gooseberry
  • Solo
  • Kiwi
  • Lychee
  • Mango
  • Melon
  • Mulberry
  • Nectarine
  • Passionfruit
  • Peach
  • Pear
  • Persimmon
  • Plum
  • Pomegranate
  • Quince
  • Raspberry
sibo food mango

Starched vegetables after SIBO treatment 

  • Carrot
  • Chestnut
  • Jerusalem artichoke
  • Parsley
  • Potato
  • Pumpkin
  • Sweet potatoes
artichoke SIBO
sibo products

More articles on SIBO

Five facts about SIBO

Treatment of SIBO

Symptoms and causes of SIBO

Diagnosis of SIBO

SIBO aggravating factors

Facts about SIBO
SIBO treatment
Symptoms, causes
Diagnosis
Aggravatings

Leaky Gut

Leaky Gut

Autism and Genes, Gut-Brain Axis, Microbiome and Gut health, SIBO

Symptoms and causes

Symptoms and causes

Normally, the bowel does not leak. However, if there is a problem with the intestinal tract, the intestinal wall can also penetrate, leading to inflammation.

On the one hand, the intestines must be sufficiently permeable to absorb nutrients and fluids. Still, they also need a defense mechanism that retains harmful substances and pathogens. The nutrients come from the outside world, i.e., many microorganisms, chemicals, and toxins are ingested daily through food and drink, which enter the body through the intestinal tract.

Formation of Leaky Gut Syndrome

The gut as a defense system

The first stop of this defense system is the barrier, i.e. the gut flora, or as it is now called: the microbiome.

The beneficial bacteria in the gut flora are capable of:

  •  To destroy pathogens
  • “Filters out” various toxins, carcinogens,
  • to produce substances that nourish the cells of the intestinal wall,
  • they also take part in mucus production, which involves the inner surface of the gut,
  • They make B vitamins, folic acid, short-chain fatty acids,
  • “Inform” the immune system of the presence of pathogens and harmful substances.

The second line of defense is the intestinal epithelial cell

In the gut, this is done by a specialized epithelial cell (epithelium), which is made up of only one layer. The intestinal mucosa is damaged by SIBO and does not ingest the pathogens due to inflammation; the duct between the intestinal cells remains open, allowing pathogens and toxins to enter the bloodstream, causing inflammation in other parts of the body, in addition to food sensitivities. Allergies develop. If SIBO is not treated for a long time, autoimmune processes may start.

The third line of defense is the gut’s immune system which is 70-80% of all immune cells in the body.

Leakage in the gut can also be caused by gluten, as gluten triggers the production of zonulin in the gut. Zonulin is a protein found in the small intestine that regulates the opening and closing of a channel between intestinal cells. When the zonulin rises, it opens the nodes, and the nodes close when the zonulin level falls down. This protein is activated by gluten, which elevates zonulin and opens nodes in the channels between intestinal cells.
While many suspect celiac diseases as the cause of their problems, SIBO is often the case.

Zonulin can also be activated and elevated by infections such as Candida overgrowth, SIBO, and parasites, and exposure to toxins and stress can all cause leaking intestinal tract.

Symptoms of a leaky gut

  • Digestive problems such as bloating, diarrhea, irritable bowel syndrome (IBS)
  • Food allergy or food intolerance
  • Brain fog, difficulty concentrating, Attention Deficit
  • Hyperactivity Disorder (ADD) or Attention Deficit Hyperactivity Disorder (ADHD)
  • Mood imbalances such as depression and anxiety, decreased ability to manage stress
  • Skin problems such as acne, rosacea, or eczema
  • Seasonal allergies or asthma
  • Hormonal imbalances such as irregular menstruation, premenstrual syndrome (PMS), or polycystic ovary syndrome (PCOS)
  • Diagnosis of autoimmune diseases such as rheumatoid arthritis, Hashimoto’s thyroiditis, lupus, psoriasis, or celiac disease
  • Diagnosis of chronic fatigue or fibromyalgia

Causes of a leaky gut

So the following can lead to the development of leaky gut syndrome:

  • colonization of harmful pathogens in the intestine
  • food allergies
  • Hidden food intolerances: these are very insidious because
  • intolerance usually develops to food that is consumed often, even every day but does not cause immediate symptoms. (gluten, casein, eggs)
  • long-term medication, antibiotics
  • digestive enzyme deficiencies
  • hormonal changes
  • abnormal fluctuations in blood sugar levels
  • persistent stress
  • Accumulation of chemicals, and toxins in the intestine

10 signs of leaky gut

  1. Chronic diarrhea, constipation, gas or bloating
  2. Nutritional deficiencies
  3. Poor immune system
  4. Headaches, brain fog, memory loss
  5. Excessive fatigue
  6. Skin rashes and problems such as acne, eczema or rosacea
  7. Cravings for sugar or carbs
  8. Arthritis or joint pain
  9. Depression, anxiety, ADD, ADHD
  10. Autoimmune diseases

If you are experiencing these symptoms, consider talking to your healthcare provider and test your microbiome with the newest technology to find out what is happening inside your gut. Re-rebuilding the gut microbiome and repairing the intestinal wall is essential to stay healthy for the long term.

Resources
  • 1] https://pubmed.ncbi.nlm.nih.gov/33171587/
  • [2] https://pubmed.ncbi.nlm.nih.gov/32902315/
  • [3] https://pubmed.ncbi.nlm.nih.gov/23851019/
  • [4] https://pubmed.ncbi.nlm.nih.gov/30394372/

    Gut and skin

    Gut and skin

    Gut-Brain Axis, Health, Microbiome and Gut health, Organic skincare, SIBO

    The link between gut and skin health

     

    If you have skin rashes or eczematous symptoms, you should never think it is a genetic condition.

    If you have long-term, chronic symptoms, you should not only see a dermatologist or switch to natural cosmetics but also remember that digestive problems and internal parasites could be behind the external symptoms.

    In nutritional studies, the skin has long been considered an indicator of intestinal issues and an imbalance of intestinal flora.

    To have clear, healthy skin, you should first regenerate your gut.

    Epidemiological studies show a clear link between intestinal problems and skin diseases.

    When skin problems do not respond properly to skin care treatments, the source of the problem is actually in the gut. A poorly functioning gut system can potentially exacerbate or lead to pre-existing skin conditions. Acne, rosacea, and perioral dermatitis are ten times more likely to occur with small intestinal bacterial infections (SIBO). Skin rashes occur in 14% of patients with ulcerative colitis and 24% with Crohn’s disease. Mucosal lesions, alopecia, and vitiligo are also more common in gluten sensitivity. Skin problems and acne may occur due to increased intestinal permeability (leaky gut) in inflammatory bowel disease.

    Studies have shown that intestinal inflammation and dysbiosis can impair the skin’s protective function. This condition, in turn, leads to a decrease in the number of antimicrobial peptides produced in the skin and may increase the severity of certain infections as part of the skin’s inflammatory response

    The intestinal flora influences the health of the skin

    The condition of the intestinal flora affects the health of the skin. The so-called neuropeptide substance P is produced in the intestine, brain, and skin and plays an essential role in the condition of the skin. An altered gut microbiome releases higher neuropeptide P levels in the gut and the skin. Higher levels of neuropeptide P affect lipid production and fatty acid profiles in tissues and can influence sebum production and fatty acid composition of sebum. Several studies have already demonstrated the positive effects of probiotics on the skin.

    Gut-skin axis

    “The GSA describes the relationship where the gut can influence skin health owing to its immunological and metabolic properties.52 Although it is difficult to strictly attribute a cause-and-effect relationship between the gut microbiome and dermatologic conditions, multiple studies support a connection between them with several cutaneous diseases being associated with GI disorders and vice versa.”(1)

    Several studies have already demonstrated the beneficial effects of probiotics on the skin. Fermented dairy products have a positive effect on intestinal flora, while unfermented dairy products can promote acne breakouts. However, be careful with fermented products if you suffer from SIBO. Oral probiotics reduce inflammation and systemic oxidative stress markers, which are locally elevated in acne. However, if you do not know anything about your microbiome, it is recommended to take only high-quality soil-based probiotics.

    “Gut microbiota influence the pathophysiology of acne via cross-talk between intestinal commensal bacteria and the mTOR pathway ()” (2)

    A well-balanced, nutrient-rich diet is critical to maintaining a healthy gut. If you do not have any particular intestinal problems, you can take probiotic supplements to increase the versatility of your intestinal flora.

    Quercetin, a powerful antioxidant, and a miracle molecule can still be beneficial. Since I have been taking Quercetin regularly, I have not had a single pimple, although I am sure that my intestinal flora is not 100% perfect.

    What can you do to improve your digestion and skin?

    • Avoid dairy, soy, gluten, and rapidly absorbable carbohydrates for at least 1-2 months.
    • Take probiotics daily. Preferably something that has been studied and proven to be effective. If you have intestinal problems, take only soil-based probiotics.
    • In the case of digestive problems, take regular “digestive enzymes ” to help your digestion, which will relieve your heavy stomach immediately after a large meal. If you do not take a digestive supplement, incorporate apple cider vinegar into your daily routine, preferably the unfiltered variety. After a meal, a tablespoon will help digest the food. It is important to support digestion with natural supplements when altered intestinal flora and impaired digestion slow down the digestion of food because, in this case, there is stagnation in the small intestine, which causes many unpleasant symptoms and inflammation.
    • Move around whenever you can!
    • I am thinking of something other than going to the gym every day. However, you should walk as much as possible if you do not have time to exercise. Introduce a 15-minute workout at a faster pace 3x per week to work your muscles and speed up your metabolism.
    • Take evening primrose oil, as its gamma-linolenic acid content reduces the symptoms of eczema, and take omega-3 capsules (1000 mg ) 2-3 times a day to reduce inflammatory processes.

    Stick to the above for at least 2-3 months, and follow a diet high in fiber, and you will surely see the change!

    Resources
    [1]

    https://www.sciencedirect.com/science/article/abs/pii/S0738081X21001930

    [2]

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048199/

    [3]

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916842/

    [4]

    https://www.dermatologytimes.com/view/gut-bacteria-linked-to-inflammatory-skin-disease

    [5]

    https://pubmed.ncbi.nlm.nih.gov/33924414/

    [6]

    Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr 2007:26:39-48.

    [7]

    https://pubmed.ncbi.nlm.nih.gov/27554239/

    [8]

    https://pubmed.ncbi.nlm.nih.gov/33921772/

    [9]

    https://pubmed.ncbi.nlm.nih.gov/33540138/

    [10]

    https://www.eurekalert.org/news-releases/903431

    [11]

    Demirel Ogut N. Link Between the Gut and Inflammatory Skin Disease Exposed. Accessed May 11, 2021. Published online May 7, 2021. https://www.eurekalert.org/pub_releases/2021-05/sc-tro050621.php

    [12]

    Stocum, Linda. “Gut Bacteria Linked to Inflammatory Skin Disease.” https://www.dermatologytimes.com/, 11 May 2021, www.dermatologytimes.com/view/gut-bacteria-linked-to-inflammatory-skin-disease.

    [13]

    Juhl, Christian R, et al. “Dairy Intake and Acne Vulgaris: A Systematic Review and Meta Analysis of 78,529 Children, Adolescents, and Young Adults.” Nutrients, U.S. National Library of Medicine, 9 Aug. 2018, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115795/.

    [14]

    Sanz, Yolanda. “Effects of a Gluten-Free Diet on Gut Microbiota and Immune Function in Healthy Adult Humans.” Gut Microbes, U.S. National Library of Medicine, 2010, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023594/.

    [15]

    Acne Vulgaris – Statpearls – NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK459173/.

    [16]

    Demirel Ogut N. Link Between the Gut and Inflammatory Skin Disease Exposed. Accessed May 11, 2021. Published online May 7, 2021. https://www.eurekalert.org/pub_releases/2021-05/sc-tro050621.php

    [17]

    Stocum, Linda. “Gut Bacteria Linked to Inflammatory Skin Disease.” https://www.dermatologytimes.com/, 11 May 2021, www.dermatologytimes.com/view/gut-bacteria-linked-to-inflammatory-skin-disease.

    [18]

    Juhl, Christian R, et al. “Dairy Intake and Acne Vulgaris: A Systematic Review and Meta Analysis of 78,529 Children, Adolescents, and Young Adults.” Nutrients, U.S. National Library of Medicine, 9 Aug. 2018, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115795/.

    [19]

    Sanz, Yolanda. “Effects of a Gluten-Free Diet on Gut Microbiota and Immune Function in Healthy Adult Humans.” Gut Microbes, U.S. National Library of Medicine, 2010, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023594/.

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