The Crucial Role of Folate in Methylation and Brain Development

The Crucial Role of Folate in Methylation and Brain Development

crucial role of folate in autism

​Folate is an essential nutrient for human health, and plays a vital role in methylation, a process important for healthy brain development. Folate, also known as vitamin B9, plays an important role in DNA methylation, a process that helps control gene expression. Adequate levels of folate are necessary for proper brain development and function. Additionally, folate is needed to convert homocysteine, an amino acid, into methionine, which is involved in the production of neurotransmitters, the chemicals that transmit signals in the brain.

What is methylation?

Methylation is a biochemical process in which a methyl group (one carbon atom with three hydrogen atoms attached) is added to an organic molecule. This process plays an important role in several biological functions, such as gene expression, epigenetics, and brain development. During brain development, methylation helps regulate the expression of certain genes that are critical for normal neuronal functioning and maturation. This process is also essential for neurotransmitter synthesis and the formation of long-term memories.

Folate works by providing the necessary methyl groups for this process, thus helping to support normal development of the brain and nervous system. In this blog post, we will explore how folate supports methylation and brain development, and why it is so important to make sure you are getting enough of it in your diet.

How does folate play a role in methylation?

Methylation is a critical biochemical process that affects many aspects of human health. Folate, also known as vitamin B9, is one of the key nutrients involved in this process. The nutrient works together with other B vitamins, such as vitamin B12, to form an important methyl group donor molecule called S-adenosyl methionine (SAMe). This molecule is then used for various chemical reactions within the body, including DNA synthesis and gene expression.

Folate is essential for healthy methylation because it allows cells to create the SAMe molecule they need to carry out the process. Inadequate amounts of folate can lead to poor methylation and can have a negative impact on brain development. Studies have shown that children who were exposed to high levels of folate during their mother’s pregnancy had improved cognitive and academic performance compared to those whose mothers had lower folate levels. Folate is therefore important for proper brain development in children and adults alike.

What are the benefits of methylation?

Methylation is an essential biological process that helps regulate gene expression, metabolic activity, and cell functioning. This process can have numerous beneficial effects, particularly in regards to brain development. Methylation plays a key role in the synthesis of DNA, RNA, and proteins, all of which are involved in healthy brain functioning. It also helps create and regulate the neurotransmitters that enable communication between nerve cells, as well as regulate gene expression related to the development of the nervous system.

Methylation is important for cognitive function too. It helps to ensure that neurons are properly developed and functioning correctly. In addition, studies have shown that it can improve learning and memory, as well as help protect against neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Finally, methylation is believed to be linked to increased protection against depression, anxiety, and other mental health issues.

Overall, methylation is an important process that helps with proper brain development and cognitive functioning. By properly supporting methylation through adequate folate intake, we can ensure that our brains are functioning at their best.

How does methylation impact brain development?

Methylation plays a crucial role in the development of the brain, particularly in regulating gene expression. During fetal development, methylation helps to define the structure and organization of the nervous system. Methylation also helps to promote the formation of neural networks, which can help the brain to better process sensory information. Additionally, methylation helps to regulate the production of neurotransmitters, which are chemicals that enable communication between neurons and are essential for proper brain development.

It has been suggested that altered methylation patterns may play a role in some neurological disorders such as autism, schizophrenia, and bipolar disorder. In fact, some studies have linked decreased methylation in certain areas of the brain with cognitive and behavioral issues. This suggests that methylation is an important factor in the development of normal brain functioning.

Furthermore, there is evidence to suggest that folate deficiency can lead to abnormal methylation patterns, which can impair brain development. Folate is necessary for the production of DNA and for cell division. It is also required for the synthesis of S-adenosylmethionine (SAMe), which is an important methyl donor used in methylation reactions. Thus, adequate folate intake is essential for normal brain development as it helps to regulate methylation reactions in the brain.

In conclusion, methylation is essential for normal brain development, as it helps to regulate gene expression, promote the formation of neural networks, and regulate neurotransmitter production. It has been suggested that alterations in methylation patterns may contribute to neurological disorders, and folate deficiency can lead to abnormal methylation patterns which can impair brain development. Therefore, it is important to ensure sufficient folate intake for optimal brain development.

Are there any risks associated with methylation?

Methylation is an important process for healthy brain development, however, there may be some risks associated with it. When folate levels are too low, it can lead to a buildup of homocysteine, which has been linked to a variety of health issues including heart disease, stroke, and even dementia. In addition, too much or too little methylation can result in a decrease in the effectiveness of various neurotransmitters, leading to mental health issues such as depression and anxiety. It is important to maintain optimal folate levels in order to ensure that the body has enough of this essential nutrient to support healthy methylation processes. For pregnant women, it is especially important to get adequate amounts of folate in order to ensure proper fetal brain development.

Resources

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147084/

Glutamate and Autism Spectrum Disorder: What’s the Link?

Glutamate and Autism Spectrum Disorder: What’s the Link?

Glutamate and autism1

Recent research has shown that glutamate, a neurotransmitter involved in the excitatory pathways of the brain, plays an important role in the development of ASD. In this blog post, we will discuss the link between glutamate and Autism and how understanding this connection may help to improve diagnosis and treatment of the disorder.

Glutamate and Its Role in Autism

Glutamate is an excitatory neurotransmitter that plays a key role in cognitive and behavioral functions. It is also implicated in autism spectrum disorder (ASD). Neurotransmitters are chemical messengers released by neurons to send signals to other cells. Glutamate is one of the most abundant neurotransmitters in the brain and is important for the normal functioning of nerve cells. It is involved in many processes including learning, memory, and synaptic plasticity. Studies have found that glutamate levels are altered in individuals with ASD. This suggests that there may be a link between glutamate and ASD.

It has been suggested that alterations in glutamate signaling could be involved in the pathophysiology of ASD. Glutamate acts on ionotropic and metabotropic receptors, which can regulate neuronal excitability. Disruptions in the glutamate system have been linked to a variety of neurological disorders including epilepsy, schizophrenia, and autism. Imbalances in glutamate signaling have been linked to an array of behavioral and cognitive problems seen in ASD. Research suggests that abnormalities in glutamatergic neurotransmission could be a contributing factor to some of the symptoms associated with ASD.

Glutamatergic neurotransmission in ASD

Glutamatergic neurotransmission is a key component of the neurological and physiological functioning of the brain. It plays an important role in learning, memory, and emotion regulation. In Autism Spectrum Disorder (ASD), there appears to be an imbalance in this system that can lead to a variety of symptoms.

Studies have found that glutamate concentrations in the brains of individuals with ASD are generally higher than those of their typically developing peers. This increased concentration can lead to an over-activation of the excitatory pathway, resulting in excitation of neurons that would normally remain inactive. This excitation can lead to a variety of symptoms associated with ASD, such as hyperactivity, impulsivity, and difficulty regulating emotions.

Other research suggests that the glutamate receptor system may also play a role in the social difficulties seen in individuals with ASD. Specifically, there may be a decrease in the activity of certain receptors in the brain, resulting in decreased social processing skills and deficits in social communication.

Overall, glutamatergic neurotransmission is an important factor to consider when trying to understand the underlying causes of autism spectrum disorder. Understanding how this system works can help researchers to better identify potential treatments and interventions to improve the lives of those with ASD.

Clinical Implications

The role of glutamate in autism spectrum disorder (ASD) is increasingly being recognized. Studies have shown that dysregulation of the glutamatergic neurotransmission system is associated with symptoms of ASD, such as social deficits, communication problems, and repetitive behaviors. This suggests that targeting the glutamate system may be a viable therapeutic approach for treating the symptoms of ASD.

One possible way to target the glutamatergic neurotransmission system is through the use of medications that modulate glutamate levels. Several medications have been studied for this purpose, including memantine, an NMDA receptor antagonist, and lamotrigine, an antiepileptic drug that has been found to reduce repetitive behaviors in some patients with ASD. Additionally, there are a number of nutritional supplements that contain glutamate-related compounds, such as taurine and glycine, which may be beneficial for reducing symptoms in some people with ASD.

Other approaches to targeting the glutamatergic neurotransmission system in ASD include behavioral therapies and deep brain stimulation. Behavioral therapies, such as Applied Behavioral Analysis (ABA) and Early Start Denver Model (ESDM), focus on teaching children with ASD how to cope with social situations and communication issues by providing a structured learning environment. Deep brain stimulation involves implanting electrodes into specific parts of the brain to modulate neural activity and has been used to reduce repetitive behaviors in some patients with ASD.

In summary, evidence suggests that dysregulation of the glutamatergic neurotransmission system plays a role in the development of ASD. Targeting this system through medication, nutritional supplements, behavioral therapies, or deep brain stimulation may be effective treatments for reducing the symptoms of ASD.

How to regulate the glutamatergic neurotransmission system with nutritional supplements

Nutritional supplements are an important part of autism treatment as they can help regulate the glutamatergic neurotransmission system.

Nutritional supplements can be used to modulate the activity of glutamate in the body, thus helping to reduce symptoms related to ASD. Omega-3 fatty acids are one type of supplement that may be beneficial for reducing inflammation and oxidative stress in the body, both of which can contribute to glutamate dysregulation. Vitamin D has also been shown to be beneficial in regulating glutamate levels, as well as providing other general health benefits.

Other supplements that may help regulate glutamatergic neurotransmission in ASD include:

  • N-acetylcysteine (NAC), which is a precursor to the antioxidant glutathione
  • Vitamin B6 and B12, which are essential for methylation and can help with the regulation of neurotransmitters
  • Curcumin, which is derived from turmeric and helps to modulate inflammation
  • Magnesium, which is important for nerve transmission and regulating neurotransmitters
  • L-theanine, which is an amino acid found in green tea and helps to reduce anxiety
  • Zinc, which is an important mineral for cognitive development

Additionally, it is important to speak to your doctor before beginning any supplement regimen as some supplements may interact with medications or cause adverse reactions.

Glutathione Redox Imbalance Linked to Autism Spectrum Disorder

Glutathione Redox Imbalance Linked to Autism Spectrum Disorder

Glutathione redox process

Glutathione is an important antioxidant in the body that helps to protect cells from damage caused by oxidative stress. Imbalances in the levels of glutathione have been linked to several neurological disorders, including autism spectrum disorder (ASD). Studies have found that individuals with ASD have lower glutathione levels and increased oxidative stress compared to individuals without ASD. The mechanism by which this imbalance may contribute to the development of ASD is not fully understood, but it is thought that the antioxidant properties of glutathione may play a role in protecting the developing brain from oxidative stress.

What is glutathione?

Glutathione is the master antioxidant of the body. It helps to maintain the balance of free radicals and reactive oxygen species, which are important for cellular metabolism. Glutathione also plays a role in maintaining the structural integrity of cells and DNA. It is present in all cells and is an essential component of many metabolic processes. Glutathione can be found in high concentrations in the liver, where it aids in detoxification processes. Low levels of glutathione can increase the risk of oxidative stress and other diseases, such as cancer. Research has shown that levels of glutathione are often lower in people with autism spectrum disorder (ASD).

Other research suggests that glutathione redox imbalance may be involved in the regulation of neural development and synaptic plasticity, which are important for the development of social behavior and communication.

A recent study has discovered an intriguing link between the redox imbalance of glutathione and autism spectrum disorder (ASD). Glutathione is an important antioxidant that helps protect cells against oxidative stress. A redox imbalance of glutathione occurs when its oxidized form, glutathione disulfide, is found in higher concentrations than its reduced form, glutathione. This imbalance has been linked to the onset and progression of ASD. In this blog post, we will explore the implications of this finding and what it means for those affected by ASD.

 

What is the link between glutathione and ASD?

Glutathione is an important antioxidant found in the body that helps to protect cells from damage caused by oxidative stress. Studies have suggested that people with Autism Spectrum Disorder (ASD) have lower levels of glutathione in their bodies compared to those without ASD. This could be due to a number of factors, such as genetic predisposition or environmental influences.

Studies also suggest that this glutathione imbalance is linked to a range of symptoms associated with ASD, such as impaired motor and cognitive development. In addition, research has shown that individuals with ASD often have a greater need for antioxidant protection than those without the disorder.

Some studies have suggested that reduced glutathione levels may contribute to inflammation and oxidative stress in the body, leading to deficits in the brain’s ability to communicate and develop properly. This can result in the behavioral and social issues that are characteristic of ASD Studies have found that decreased glutathione levels and elevated hair mercury levels are associated with nutritional deficiency-based autism. A study conducted in Oman found that children with autism had significantly lower levels of glutathione and higher levels of mercury in their hair compared to typically developing children. The study also found that many children with autism had nutritional deficiencies, including deficiencies in essential minerals such as zinc, selenium, and magnesium, which are important for the synthesis and function of glutathione. The study suggests that nutritional deficiencies may contribute to the development of autism by disrupting the balance of glutathione and increasing the levels of oxidative stress and mercury toxicity in the body. This highlights the importance of ensuring proper nutrition in the management and prevention of autism.

What are the benefits of improving glutathione levels?

Research suggests that improving glutathione levels can provide many benefits for those with autism spectrum disorder (ASD). Glutathione is a powerful antioxidant and detoxifying agent, which can help to reduce oxidative stress in the body. When the body is under oxidative stress, it is more likely to experience inflammation, which can lead to an array of physical and mental health issues, including ASD. Therefore, by boosting the levels of glutathione in the body, it is possible to reduce inflammation and thus improve the symptoms associated with ASD.

In addition to its anti-inflammatory effects, improving glutathione levels can also have a positive impact on the symptoms of ASD. Studies suggest that glutathione plays an important role in regulating the neurotransmitters in the brain, which are responsible for mood, behavior, and learning. By increasing the amount of glutathione available, it is possible to regulate these neurotransmitters, resulting in improved social and communication skills, better sleep patterns, and a decrease in anxiety and other behavioral problems.

Finally, improving glutathione levels can also have a positive impact on the overall health and well-being of those with ASD. Glutathione is an essential component for proper immune system functioning and has been linked to improved cardiovascular health. By boosting glutathione levels, it is possible to improve the body’s ability to fight off infections and disease, resulting in improved physical health and well-being.

In conclusion, there are numerous benefits associated with improving glutathione levels for those with autism spectrum disorder. By reducing oxidative stress and inflammation, regulating neurotransmitter activity, and improving overall health and well-being, it is possible to see improvements in both physical and mental health symptoms associated with ASD.

How can you improve glutathione levels?

Improving glutathione levels is possible, and it can help to support autism spectrum disorder (ASD) symptoms. The most effective way to increase glutathione levels is through dietary changes, supplements, and lifestyle modifications.

There are certain foods that are known to increase glutathione levels. These include foods such as cruciferous vegetables like kale, broccoli (mainly sulforaphane in broccoli sprouts), and Brussels sprouts; garlic; onions; eggs; asparagus; avocado; walnuts; spinach; citrus fruits. Additionally, increasing the intake of antioxidant-rich foods, such as berries and dark green leafy vegetables, may also support healthy glutathione levels.

In addition to dietary changes, there are a few supplements available that can help boost glutathione levels.

What are the dietary supplements that can boost glutathione levels

​Several dietary supplements have been shown to boost glutathione levels in the body. These include:

  • N-acetylcysteine (NAC)
  • S-adenosylmethionine (SAMe)
  • Alpha-lipoic acid (ALA)
  • Milk thistle
  • Selenium
  • Vitamin C
  • Vitamin E 
  • Quercetin
  • Sulforaphane
  • Curcumin

Can sulforaphane boost the glutathione level of the body?

​Sulforaphane is a compound found in cruciferous vegetables, such as broccoli, cabbage, and cauliflower, that has been shown to have antioxidant and anti-inflammatory properties. Studies have suggested that sulforaphane may have a potential to boost the level of glutathione in the body. Research have shown that sulforaphane can activate the Nrf2 pathway, which can then increase the production of glutathione and other antioxidant enzymes in cells. However, it’s important to note that more research is needed to confirm the effects of sulforaphane on glutathione levels in the body.

Can quercetin boost the glutathione level of the body?

Quercetin is a flavonoid that is found in many fruits, vegetables, and herbs. It has been shown to have antioxidant and anti-inflammatory properties. Some studies have suggested that quercetin may have the potential to boost glutathione levels in the body. Some research has shown that quercetin can increase the activity of enzymes that are involved in the production of glutathione, such as glutathione reductase and glutathione peroxidase. However, more research is needed to confirm the effect of quercetin on glutathione levels. It’s also important to note that dietary supplement of quercetin is not recommended as it may have some potential side effects.

Can curcumin boost the glutathione level of the body?

Curcumin is a compound found in turmeric that has been shown to have antioxidant and anti-inflammatory properties. Some studies have suggested that curcumin may have the potential to boost glutathione levels in the body. Research has shown that curcumin can increase the activity of enzymes that are involved in the production of glutathione, such as glutathione reductase and glutathione S-transferase. Curcumin can also increase the expression of the genes that are responsible for the production of glutathione. Additionally, studies have suggested that curcumin may help to preserve existing levels of glutathione in cells, which would help to protect against oxidative stress and inflammation. However, more research is needed to confirm the effect of curcumin on glutathione levels.

Resources

https://www.sciencedirect.com/science/article/abs/pii/S0891584920311539

Could Methylation Issues be the root cause of Autism?

Could Methylation Issues be the root cause of Autism?

Root cause of autism

Can methylation problem be the root cause of autism? Methylation has been identified as a possible factor in autism. Recent research suggests that metabolic biomarkers of increased oxidative stress and impaired methylation capacity may be associated with autism in children. This raises the question: Could methylation issues be at the root of autism? In this blog post, we will explore how methylation issues may be linked to autism and examine the potential implications of these findings.

Root cause of autism? Can it be the problem with the methylation?

Everybody wants to know the root cause of autism. Methylation issues could be one of the main factors. Methylation is an important process that helps regulate gene expression, DNA repair, neurotransmitter production, and other metabolic activities in the body. It’s a process of transferring a small molecule, called a methyl group, from one molecule to another. This process helps control the activity of certain genes by either turning them on or off. When the body can’t methylate properly, it leads to increased oxidative stress. Oxidative stress occurs when there is an imbalance between the production of free radicals and the body’s ability to counteract their damaging effects. This can lead to further health problems if left unaddressed.

Methylation is a biological process that regulates gene expression. Abnormal methylation patterns have been associated with various neurodevelopmental disorders, including autism. In individuals with autism, abnormal methylation can impact the expression of genes involved in brain development and function, leading to changes in brain connectivity, synaptic plasticity, and neurotransmitter function, which can contribute to symptoms such as difficulty with social communication, repetitive behaviors, and restricted interests.

What are the Symptoms of Methylation Issues?

Methylation is an essential process that helps the body maintain healthy functions and processes. When it’s impaired, several symptoms can arise. Symptoms of methylation issues may include fatigue, poor memory, chronic pain, mood swings, anxiety, depression, food sensitivities, and digestive problems. Additionally, impaired methylation can lead to increased oxidative stress, when the body’s cells become damaged by free radicals and other toxins. This can manifest as systemic inflammation and an increased risk for certain diseases. Identifying and treating methylation issues is critical for maintaining good health.

What Causes Methylation Issues?

A variety of factors can cause methylation issues. The most common are genetic predisposition and oxidative stress. Oxidative stress occurs when there is an imbalance between the production of free radicals and the body’s ability to detoxify them. It is a key factor in many diseases and disorders, including autism.

Genetic mutations that affect methylation may also contribute to the development of methylation problems. These mutations can be inherited or acquired over time, due to environmental factors such as exposure to toxins. Chronic inflammation can also hurt methylation, leading to an imbalance between the production and breakdown of methyl groups.

In some cases, methylation issues can be caused by underlying nutritional deficiencies. For instance, deficiencies in certain vitamins and minerals, such as vitamin B12, folate, zinc, and magnesium, can all impact methylation pathways. Poor dietary habits, such as consuming processed foods and eating too many sugary foods, can also contribute to methylation issues.

Finally, chronic stress can also contribute to impaired methylation. When the body is under constant stress, it can produce hormones like cortisol which can affect how the body processes nutrients and affects its ability to produce energy. This can lead to changes in methylation levels, leading to a range of health issues.

How is Methylation Testing Done?

Methylation testing is an important step in determining the causes of impaired methylation capacity and increased oxidative stress in children with autism. Methylation tests measure the levels of several key compounds involved in the body’s methylation pathways. This includes the biomarkers S-adenosylmethionine (SAMe), homocysteine, folate, vitamin B12, and other important molecules related to oxidative stress.

Methylation testing is most often done using a blood sample. However, other samples such as urine, saliva, or hair can also be used. Depending on the test being done, the sample will then be analyzed to measure the levels of different biomarkers associated with methylation pathways. The results of the test can provide valuable insight into the functioning of the methylation pathways and indicate if increased oxidative stress is present. This can help guide treatment decisions and lead to better outcomes for children with autism.

What are the Treatment Options for Methylation Issues?

Methylation issues can be addressed through both conventional and alternative treatments. Conventional treatments often focus on managing symptoms and providing support to those affected by autism. These treatments may include dietary interventions, medications, speech and language therapy, and behavioral therapy.

Alternative treatments, such as antioxidant supplements, may also reduce oxidative stress in individuals with methylation issues. Antioxidants reduce the amount of free radicals in the body, which are thought to play a role in developing many chronic illnesses. Antioxidants may also help to boost the body’s natural defenses against oxidative stress. Some antioxidants that may benefit individuals with methylation issues include vitamin C, vitamin E, CoQ10, N-acetylcysteine, and glutathione. Additionally, consuming a diet rich in antioxidants from fruits and vegetables may also be beneficial. For more information on the biomedical treatment of autism check this page.

Resources

https://pubmed.ncbi.nlm.nih.gov/15585776/

Passive exercises for children with developmental delay or brain injury

Passive exercises for children with developmental delay or brain injury

passive exercises

Autism, also known as autism spectrum disorder (ASD), is a developmental disorder that affects communication and social interaction. The severity of ASD can vary widely, and different individuals with ASD may experience different symptoms.

First month

  1. rocking, listening to fairy tales, the tale should be about the child.
  2. swinging: for 20 minutes, during which we rhymes
  3. rotation as long as they can stand: child stands with his back to the parent, holds it under his armpits and the parent rotate the child
  4. rolling around the longitudinal axis; you can carefully wrap the child in a blanket and spin it out by holding one end of the blanket. Older kids should roll about 40m
  5. Hip rotation: hands in baby posture during lying on the back, feet on soles, knees-head turning in opposite directions
  6. Throwing into a pillow from different heights, if the child is big, just push into the pillow 20x. A large bean bag is the best for this
  7. Jumping on a trampoline: if the child is small just sit the child in front of your leg and you jump, the kid bounces up and down
  8. Vigorous massaging of fingertips and nail beds on hands and feet, there are a lot of nerve endings there, this is a powerful stimulation for the child

Second month

  1. Rocking, and listening to fairy tales or music
  2. Swinging: rotate in the swing and let it spin 5-6x
  3. Rotate upside down, too, holding the hips of the child. In the case of a bigger kid use a swivel chair and lie the kid upside down.
  4. Back rotation, holding the back of the head, walking around the parent
  5. Hip rotation, with legs stretched.
  6. Throwing into a pillow while lying down with chin pressed against chest (hold your favorite plush)
  7. Jumping on trampoline

In the case of an autistic child: if there is a problem with touch: the sense of touch may be underactive or the child cannot be touched:
• 20x20cm piece of velvet, silk, linen, terrycloth, or other material

• caress the child with a different substance every day; later the child should choose which one he wants

Third month

  1. Rocking, listening to fairy tales, music, over 5 years old content telling can also be requested
  2. Swinging, balance swinging.
  3. Flying: child lying on his stomach dad is standing and he starts spinning with the child in a circle or use swivel chair
  4. Rotation: lying down on the back, hands in baby pose, legs pulled up, hip rotation, head against
  5. Standing, head nodding forward 10x , back 10x
  6. Unfolding from the packaging; the child lies on his back, wrapp up his hand or feet, left hand, right hand, left foot, right foot, head 10x
  7. Closing fingers one by one, with rhymes, in the rhyme should include the name of the finger; we can hold the fingers or we move them
  8. Jumping on trampoline
Resources
  • m B-R, SeoH-S, Ku J-M, et al. Silibinininhibits the production of pro-inflammatory cytokines through inhibition of NF-κB signaling pathway in HMC-1 human mast-cells. Inflammation. Research. 2013;62(11):941-950. doi:10.1007/s00011-013-0640-1.
  • ChapowalA. PetasitesStudy Group. Randomisedcontrolled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324:144-6.
  • Hayes, N. A. and Foreman, J. C. The activity of compounds extracted from feverfew on histamine release from rat mast-cells. J Pharm Pharmacol1987;39(6):466-470
  • Hsieh et al. Baicalein inhibits IL-1ß- and TNF-a-induced inflammatory cytokine production from human mast-cells via regulation of the NF-?B pathway. ClinMolAllergy. 5: 5. 2007.
  • TheoharidesTC, Patra P, Boucher W, et al. Chondroitin sulphateinhibits connective tissue mast-cells. British Journal of Pharmacology. 2000;131(6):1039-1049. doi:10.1038/ sj.bjp.0703672.
  • Ro JY, Lee BC, Kim JY, et al. Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast-cells activated with specific antigenantibodyreactions. J PharmacolExpTher. 2000;292:114–121. 73.
  • https://www.ncbi.nlm.nih.gov/pubmed/24477254
  • https://www.ncbi.nlm.nih.gov/pubmed/28458279
  • https://www.ncbi.nlm.nih.gov/pubmed/9421440
  • https://www.ncbi.nlm.nih.gov/pubmed/10344773
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315779/
Delacato method: with movement for intellectual development

Delacato method: with movement for intellectual development

Carl-Henry Delacato method

According to the theory developed by Philadelphia neurologist Carl Henry Delacato and his team, there is a close connection between movement and the development of the nervous system, and intellectual development. So if the child does not have a way to practice some form of movement, it must be replaced later for proper brain development.

According to the theory, individual development follows the path of stock development, so the child copies the development process that took place when he became a human in his first years.

There is a close connection between movement and the maturation of the nervous system. If the child did not have time to practice a form of movement – either because he missed it or because the next step followed too soon, for example he started walking very early and therefore did not climb for long enough – this affects later development and even causes learning difficulties and can also cause behavior.

According to the method, the child relives an earlier period of life through movement, thus bringing in your backlog.

Delacato method can be used for intellectual development?

  • Delayed/defective/stuttering speech development
  • Speech error
  • Dyslexia/dysgraphia
  • Attention deficit disorder
  • Mild intellectual disability
  • Clumsy movement
  • Poor orientation skills
  • Integration problems

How does the treatment take place?

According to Delacato, elementary movements – crawling, climbing, walking, swimming – reveal the development of each area of ​​the nervous system. After a condition assessment, the child is given a set of 8-10 exercises, which must be repeated at home for 20-30 minutes every day. You only have to appear at one control examination a month, when you will receive a new set of exercises taking into account your progress.

The tasks develop balance, spatial perception and fine movement.

It is becoming more and more common for specialists who mainly deal with large groups to visit kindergartens as well. In such cases, 90-minute classes are held for groups of 4-5 people.

Children and young people between the ages of 5 and 16 can take part in the therapy. Since the goal of the development is to practice the missed forms of movement,teenagers do the same exercises that preschoolers do: crawling, climbing, balancing, allowing their brains and nervous systems to acquire skills that were missed in the first period.

Let's have some exercise

Check out some brain developing exercises in the related articles:

Passive exercises for children with developmental delay or brain injury

Exercises for brain and intellectual development Part 1

 

Movement developmental milestones: What should you pay attention to?

Movement developmental milestones: What should you pay attention to?

development milestones

Children grow and develop at their own pace. This is a fact that a parent must be able to accept, just like the fact that their child may start walking or talking later. If your child does not reach certain developmental milestones, it is recommended to visit a specialist. Which milestones should you focus on?

There are children who, in terms of development, show almost a textbook example and reach each milestone on a daily basis. Then there are children who surpass their peers in everything, and there are those who develop at a slower pace , but still within the tolerance limit. When should you start worrying?

At the age of 0 - 4 months

Babies grow very quickly in the first months after birth, so parents can witness changes on a daily basis. A healthy newborn gains 140-200 grams in the first week and grows 1-2.5 cm per month. Children literally grow before our eyes and learn new skills at the same time. They must reach a certain level of development in the first four months of their lives . If you notice any of the following symptoms during this period, see your pediatrician as soon as possible, as they may indicate a developmental or other abnormality:

  • squeals
  • does not pay attention to loud noises
  • he doesn’t look at his hands
  • does not follow moving objects with his eyes
  • does not grab objects
  • he does not smile or laugh at the people around him
  • he can’t keep his head
  • not goofy and/or imitate sounds
  • does not put objects in his mouth
  • does not strain its paws when they touch a solid surface

At the age of 5 – 7 months

As the baby grows, its abilities and skills also develop. The five- to seven-month-old baby smiles, laughs, is excited . He grabs different objects, tastes them, snorts and makes noise. His world is expanding and he is discovering more and more of it every day. As with the previous one, there are defining milestones in this period , so be aware if you experience the following symptoms:

  • his posture is stiff, his muscles tense
  • his muscles are relaxed, with a rag doll posture
  • he does not hold his head, his head leans back even in a sitting position
  • he only reaches for the objects with one hand
  • rejects babysitting
  • it is not attached to the person taking care of it
  • he is sensitive to light, his eyes water
  • he finds it difficult to put his hand in his mouth
  • it does not turn over in the fifth month
  • he can’t even sit with help until the sixth month
  • you don’t laugh or make a sound until the sixth month

At the age of 8 – 12 months

When they light the first candle on the birthday cake, they most likely already have a ready-made personality at home. The past months have brought physical, mental, social and emotional changes in the baby’s life, and in terms of development, further milestones lie ahead. Around 75% of children achieve these in a certain period. Watch for the following symptoms:

  • does not climb or does not climb regularly, e.g. pulls one side
  • unable to stand even with support
  • does not search for objects hidden in plain sight
  • he hasn’t said the first word yet
  • does not gesticulate, e.g. he does not shake his head at the answer “no”.
  • does not point to pictures or objects

Up to 2 years old

Intensive development also takes place during childhood. At the age of two, the majority of children are walking, talking, jumping, running … a little one is simply everywhere. During this very active period, many parents notice when something is wrong with their child. Why do not you speak? Why doesn’t he come? Why don’t you play the games? If you notice any of the following symptoms, do not hesitate and notify your child’s doctor:

  • knows and uses less than 15 words
  • does not use two-word sentences
  • does not imitate words, sounds or movements
  • unable to follow simple instructions (not to be confused with disobedience)
  • cannot push wheeled toys
  • It does not go until the age of 18 months
  • even if you walk, you don’t use all parts of your foot (ie from toe to heel)

At the age of 3

The time flew by in a flash and it has now dwindled to three years. If your child has a developmental disorder , you’ve probably already discovered it, but there are still symptoms that cause concern:

  • often falls and cannot climb stairs
  • drools continuously and/or his speech is unintelligible
  • cannot use more than 4 cubes when building a tower
  • cannot manipulate small objects
  • cannot draw a circle
  • unable to communicate in short sentences
  • he is not interested in group play, he does not participate in it
  • does not understand simple instructions
  • no longer interested in children
  • does not maintain eye contact
  • shows little interest in games

A parent knows their child best. He is the best able to assess his development and follow the progression of his behavior and skills. We always emphasize that comparison with peers is inappropriate because children develop at their own pace, but this does not mean that the child should not be monitored. If you feel that everything is not right, or if you have noticed one of the symptoms mentioned above , contact a specialist who will order the necessary tests.

Resources
  • m B-R, SeoH-S, Ku J-M, et al. Silibinininhibits the production of pro-inflammatory cytokines through inhibition of NF-κB signaling pathway in HMC-1 human mast-cells. Inflammation. Research. 2013;62(11):941-950. doi:10.1007/s00011-013-0640-1.
  • ChapowalA. PetasitesStudy Group. Randomisedcontrolled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324:144-6.
  • Hayes, N. A. and Foreman, J. C. The activity of compounds extracted from feverfew on histamine release from rat mast-cells. J Pharm Pharmacol1987;39(6):466-470
  • Hsieh et al. Baicalein inhibits IL-1ß- and TNF-a-induced inflammatory cytokine production from human mast-cells via regulation of the NF-?B pathway. ClinMolAllergy. 5: 5. 2007.
  • TheoharidesTC, Patra P, Boucher W, et al. Chondroitin sulphateinhibits connective tissue mast-cells. British Journal of Pharmacology. 2000;131(6):1039-1049. doi:10.1038/ sj.bjp.0703672.
  • Ro JY, Lee BC, Kim JY, et al. Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast-cells activated with specific antigenantibodyreactions. J PharmacolExpTher. 2000;292:114–121. 73.
  • https://www.ncbi.nlm.nih.gov/pubmed/24477254
  • https://www.ncbi.nlm.nih.gov/pubmed/28458279
  • https://www.ncbi.nlm.nih.gov/pubmed/9421440
  • https://www.ncbi.nlm.nih.gov/pubmed/10344773
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315779/
Brain plasticity exercises

Brain plasticity exercises

Brain neuroplasticity in asd

Neuroplasticity refers to the brain’s ability to reorganize itself by forming new connections between brain cells (neurons) and by altering the strength of existing connections. This process allows the brain to adapt and learn new skills, as well as to compensate for injuries or diseases.

How to improve the brain neuroplasticity?

Several studies have demonstrated that brain plasticity improves brain recovery neurologists often use brain plasticity to describe rehabilitation after injury. Adult brains are not hard-wired; it is crucial to keep this in mind in the brain. Many wirings are created with a fixed neural circuit. The neural connections aren’t what most people think they are. There is scientific evidence that cortical neurons don’t die as we age. Injuries and training lead to subcortical rewiring in the brain.

Brain Plasticity: Exercises part 1

Research has shown that neuroplasticity can be enhanced through certain activities and experiences. Many scientists believe that humans need to exercise their brains for a long time during childhood, the brain stops developing, so we lose neurons every year until we reach adulthood
modern research indicates that the brain is still capable of developing.
Throughout our lives, we form neural connections based on our experiences.

To stay healthy, you must exercise both your brain and your body. We lose neurons every year until age because many scientists believe the brain stops developing in childhood. Researchers have found, however, that our brains continue to establish neural connections throughout our lives.
addition,
Everyone can improve neuroplasticity by doing exercises that can make the brain even stronger despite the factors leading to brain damage, like environmental stress, drugs, and aging. Like doing aerobic exercises for your heart, it’s just as important to condition your brain by exercising regularly.

Rules for Brain Plasticity Workouts

Before you get started exercising the brain, it is important to make sure you are aware of the cautions and rules in order to ensure that you are getting the best results and get the most out of it. Neurons that are not stimulated well will die so all of your attempts to reconnect will be useless. Below are the rules:

Practice regularly

Neurons that are not stimulated enough usually fail to reconnect. This is especially true if somebody has been suffered from brain injuries. It is crucial to start doing neuroplasticity exercises even before your neurons start to die. If you practice regularly, not only will your neural connections flourish but your neurons will also be regenerated according to many studies.

Learn new skills

Learning new skills, such as a new language or instrument, can stimulate the formation of new connections in the brain and enhance neuroplasticity.

Exercises need to be balanced.

It is important to take note that repeating brain exercises for countless of times can lead to the overstimulation of the brain cells in the targeted areas.

Practice every day.

Exercise regularly. It is worth constantly stimulating the brain with varied tasks.

What activities increase neuroplasticity?

  • 3D adventure games appeared to improve memory, problem-solving, and scene recognition.
  • Puzzles improve problem-solving skills, brain connections, and spatial prediction.
  • Rhythmic games, such as dance or exercise video games, can improve visuospatial memory and attention.
  • Learn a new language. A second (or third) language might improve your career prospects, or you want to learn it for fun. Either way, you’re doing your brain a big favor. There is a lot of evidence that learning a new language improves cognitive function. Increase the grayness…In a 2012 study, researchers studied ten English-speaking exchange students studying German in Switzerland. After five months of intensive language training, their German language skills increased – and so did the density of gray matter in their brains. Your brain has many vital areas of gray matter, including areas related to language, attention, memory, emotions motor skills. Increasing gray matter density can improve your function in these areas, especially with age. Bilingualism is thought to offer protection against cognitive decline. Language learning at any stage of life can slow future decline with age and the symptoms of dementia. Learning a new language increases gray matter density and neuroplasticity.
  • Music has many benefits for the brain. It can help improve: your mood, and your ability to learn and remember new information; concentrate and concentrate; music therapy also appears to help slow cognitive decline in older adults. According to a 2017 study, music, especially when combined with dance, art, play, and exercise, helps promote neuroplasticity. It can improve movement and coordination and can help strengthen memory. But it simply won’t help prevent further cognitive decline. It can also help relieve emotional stress and improve quality of life. According to a 2015 review, musical training is also useful as neuroplasticity training. Learning to play music in childhood may help protect against age-related cognitive decline and improve cognitive performance in older adulthood. A reliable source also suggests that musicians often have: better auditory and visual perception, better concentration, better memory better motor coordination. It’s never too late to learn an instrument.
  • Most people know that exercise offers many physical benefits but physical activity also strengthens the brain. Exercise – especially aerobic exercise – can improve cognitive skills such as learning and memory. According to a 2018 literature review, exercise helps improve fine motor skills and brain connections and may protect against cognitive decline. Neuroplasticity exercise helps promote blood flow and cell growth in the brain. You’ll likely see social benefits if you train with someone else or in a larger group. Social connections help improve quality of life and emotional well-being, so regular interaction with others can be another great way to improve brain health and reduce symptoms of anxiety and depression. Exercise recommendations may vary based on health and ability, but it’s a good idea to get at least some exercise daily.
  • Making art can help you see the world in a new and unique way. You can use art to sort out and express emotions, share personal experiences, or gain deeper insights.
  • Get enough sleep: Sleep is important for brain health because it allows the brain to rest and repair itself. Adequate sleep can improve brain function and increase neuroplasticity.
  • Healthy diet: A diet rich in vegetables, fruits, and other nutrients has been shown to support brain health and increase neuroplasticity.
  • Practice meditation: Meditation and mindfulness practices have been shown to improve brain function and increase neuroplasticity.
  • Stay mentally active: Engaging in mentally challenging activities like puzzles and games can help keep your brain active and stimulate the growth of new brain cells.
  • Be Socially Active: Connecting with others and maintaining strong social ties has been shown to benefit brain health and increase neuroplasticity
Resources
  • m B-R, SeoH-S, Ku J-M, et al. Silibinininhibits the production of pro-inflammatory cytokines through inhibition of NF-κB signaling pathway in HMC-1 human mast-cells. Inflammation. Research. 2013;62(11):941-950. doi:10.1007/s00011-013-0640-1.
  • ChapowalA. PetasitesStudy Group. Randomisedcontrolled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324:144-6.
  • Hayes, N. A. and Foreman, J. C. The activity of compounds extracted from feverfew on histamine release from rat mast-cells. J Pharm Pharmacol1987;39(6):466-470
  • Hsieh et al. Baicalein inhibits IL-1ß- and TNF-a-induced inflammatory cytokine production from human mast-cells via regulation of the NF-?B pathway. ClinMolAllergy. 5: 5. 2007.
  • TheoharidesTC, Patra P, Boucher W, et al. Chondroitin sulphateinhibits connective tissue mast-cells. British Journal of Pharmacology. 2000;131(6):1039-1049. doi:10.1038/ sj.bjp.0703672.
  • Ro JY, Lee BC, Kim JY, et al. Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast-cells activated with specific antigenantibodyreactions. J PharmacolExpTher. 2000;292:114–121. 73.
  • https://www.ncbi.nlm.nih.gov/pubmed/24477254
  • https://www.ncbi.nlm.nih.gov/pubmed/28458279
  • https://www.ncbi.nlm.nih.gov/pubmed/9421440
  • https://www.ncbi.nlm.nih.gov/pubmed/10344773
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315779/