The glutathione precursor

The glutathione precursor

Autism and Genes, Detoxification, Health, Microbiome and Gut health

N-Acetyl-L-Cysteine (NAC) is one of the most exciting antioxidant amino acids of our time. An anti-inflammatory agent, one of the precursors to glutathione, which referred to as a master antioxidant (1). That is why we recommend the combined use of our NAC and Glutathione products.

The mucolytic, antitussive effect of NAC has long been known in the health circles because of its ability to break down disulfide bridges in mucus and secretions (1).

New research has highlighted other important aspects: its effects on stabilizing blood sugar levels (2) (insulin resistance, adjusting blood fat levels), increasing fertility and protecting the nervous system have innovative potential.

N-Acetyl Cystein the glutathione precursor

“The glutathione precursor” what does it mean? Glutathione, also known as GSH, is a molecule found naturally in your body. It is produced by the liver and nerve cells in the central nervous system. Glutathione is made up of three amino acids: L-cysteine, glycine, and L-glutamate.
Glutathione is an antioxidant, a molecule that helps fight free radicals. When more free radicals exist than antioxidants, oxidative cell damage occurs. This can lead to inflammation and a variety of health issues.
In addition to being an antioxidant,

Acetyl-L-Cysteine (NAC) is one of the most exciting antioxidant amino acids of our time. An anti-inflammatory agent, one of the precursors to glutathione, which referred to as a master antioxidant [1].

A Powerful Antioxidant

N-acetylcysteine, derived from the simple amino acid cysteine, provides significant protection against a broad array of modern toxins. 

NAC is a precursor of glutathione. Glutathione is the body’s most important antioxidant, found in every single cell. It is also called a “master antioxidant” because it exerts its effects within cells and its unique ability to maximize the effects of all other antioxidants, including vitamins C and E, Q + Ubiquinol, r-alpha-lipoic acid.

The primary function of Glutathione is to protect cells and mitochondria from the damaging, destructive effects of internal oxidation processes (2). It protects the integrity of our cells, tissues and organs, thus playing an important role in the fight against chronic diseases associated with aging. Glutathione is key to detoxification, neutralizing toxins in the body, protecting against the harmful effects of radiation, chemicals and environmental contaminants.

It improves the functioning of the immune system, has a nervous system protection effect, increases the body’s resistance to infections, can speed up the recovery from diseases, and increases the body’s energy levels and vitality (3).

For a healthy immune system

Glutathione plays an important role in maintaining the healthy functioning of the immune system. Oxidative stress caused by viral infections causes inflammation in the cells and glutathione levels are demonstrably reduced.

Decreased immunity and an increased risk of infections are associated with low glutathione levels (4). Glutathione is beneficial in increasing the number of T cells in immune leukocytes and NK cells in natural killer cells (5). Glutathione deficiency can be detected in autoimmune diseases.

Research has shown that glutathione has a positive effect on the normal functioning of the immune system and prevents the development of an excessive immune response and inflammation in autoimmune diseases (6).

Liver protection, detoxification

Glutathione is found in the highest concentrations in the liver and kidneys. The liver plays a prominent role in the II. in phase detoxification processes (7). Helps remove toxins, foreign chemicals, potential carcinogens, hormones, pollutants.

It converts them into water-soluble substances that can now be easily excreted from the body through the kidneys. Glutathione is also present in the entire intestinal mucosa, where it captures and neutralizes potential toxins before they are absorbed into the body. Glutathione protects the intestinal wall, which, if weakened, can lead to a leaking / permeable intestinal problem (8).

The detoxification ability of glutathione can be further enhanced by other sulfur-containing molecules: cruciferous plants (broccoli), r-alpha-lipoic acid, N-acetyl cysteine, turmeric, St. John’s wort and B vitamins, selenium, and the like. 

Excessive consumption of over-the-counter drugs containing paracetamol (eg, antipyretics, analgesics, etc.) can lead to hepatotoxicity and deplete the body’s glutathione system. NAC is able to rehabilitate toxic processes in liver cells.

Acetyl-L-Cysteine increases the body’s glutathione levels, enhances the immune system through its antioxidant effect, helps cellular regeneration and reduce inflammation, and contributes to the effective elimination of toxins and toxins.

It contributes to the multi-level detoxification processes of the liver, and also promotes the rehabilitation of liver cells in the state of fatty liver. In this case, Choline and Inositol can help in the detoxification process.

Protecting the brain and nervous system

Our brain uses a lot of oxygen and is therefore extremely vulnerable to oxidative damage. This oxidative damage adversely affects neurological functions and our development, which can lead to mitochondrial dysfunction and a number of neurodegenerative diseases. Glutathione protects brain cells against odiation.

Low glutathione levels increase the risk of developing neurodegenerative diseases. Heavy metals that accumulate in the brain can cause severe oxidative stress and cell damage. Glutathione has the ability to detoxify toxic metals in the brain, thereby protecting the health of the nervous system (9).

Energy production of cells, enhancement of vitality

Mitochondria are responsible for the energy production of our cells in the form of adenosine triphosphate (ATP). The function of mitochondria also plays a vital role in cell health, intercellular communication, regulated cell death, and cell growth.

Researchers today believe that mitochondrial health is directly linked to our aging processes and the resistance of cells to degenerative diseases. Glutathione has the potential to improve mitochondrial health and directly affect our energy-producing abilities.

By-products of cellular metabolism are also free radicals that are destructive. They are also able to neutralize glutathione (10).

NAC in relation to the hormonal system and fertility

Research results support its effectiveness in reducing ROS (reactive oxygen species) levels, combined with vitamins A, E and Omega-3 fatty acids. Other literature has also described the combination of NAC and selenium as effective (11). High ROS levels presuppose inflammation and affect the DNA of sperm.

It supports the ovarian cycle, i.e. the cycle of ovulation, thereby positively affecting fertility (12). By stimulating glutathione levels, it has a positive effect on insulin secretion and increases insulin sensitivity, so it can be used as an adjunct in the treatment of insulin-resistant conditions in polycystic ovary syndrome, which is closely related to insulin resistance (13).

Furthermore, a human study highlights the effect of NAC on cysts that cure-like use of NAC may reduce the potential for cysts due to endometriosis (14). In such cases, I strongly recommend Glutathione, Choline + Inositol.

The role of NAC in the functioning of the respiratory system

As a mutolytic, Acetyl-L-Cysteine ​​supports the emptying of difficult-to-break secretions and can therefore help with prolonged, persistent coughs (colds, flu, bronchitis (15).

Research has been shown to be effective in the adjunctive treatment of COPD [8]. Due to its powerful antioxidant effect, it can reduce the condition of chronic inflammation. According to the research, Acetyl-L-Cysteine ​​intake promoted physical activity and performance in patients with COPD.

By increasing glutathione levels, it can reduce the inflammatory state of lung tissue and contribute to its regeneration.

What else does NAC help

  • To clean the lungs of the secretion due to smoking.
  • In the adjunctive treatment of COPD
  • Prevention of respiratory infections, alleviation of pre-existing symptoms (persistent cough)
  • Endometriosis, in the adjunctive treatment of PCOs for fertility problems (both women and men)
  • In post-contraceptive rehabilitation (in such cases we also recommend our Broccoli & Watercress, Choline & Inositol products)
  • To detoxify the liver, regenerate liver cells, lower triglycerides In case of blood sugar and insulin homeostasis problems, in the adjunctive treatment of insulin resistance
  • Nervous system, to support nerve cells and to increase memory
  • Metabolism of toxins and cancer-causing substances
  • Natural creation and repair of DNA
  • Production of protein and prostaglandin, a compound with hormone-like effects
  • Activation of enzymes
  • Glutathione also helps with the breakdown of nutrients and the regulation of important body processes, such as the immune response.
  • A small study published in Medical Science Monitor in 2011 shows a connection between low glutathione levels and autism spectrum disorders.
  • The mucolytic, antitussive effect of NAC has long been known in the health circles because of its ability to break down disulfide bridges in mucus and secretions .
  • It is also used as an antidote in problems with paracetamol overdose to protect liver cells.
  • New research has highlighted other important aspects: its effects on stabilizing blood sugar levels (insulin resistance, adjusting blood fat levels), increasing fertility and protecting the nervous system have innovative potential.
  • N-acetylcysteine (NAC) is effective both in inhibiting biofilm formation and in destroying developed biofilms. (12)
Resources
  • [1] Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio F. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018 Jul;52(7):751-762
  • [2] Samuni Y, Goldstein S, Dean OM, Berk M. The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta. 2013 Aug;1830(8):4117-29.
  • [3] Fulghesu AM, Ciampelli M, Muzj G, et al. N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril. 2002 Jun;77(6):1128-35.
  • [4] Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009 Feb;181(2):741-51.
  • [5] Badawy A, State O, Abdelgawad S. N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial. Acta Obstet Gynecol Scand. 2007;86(2):218-22.
  • [6] Porpora MG, Brunelli R, Costa G, Imperiale L, Krasnowska EK, Lundeberg T, Nofroni I, Piccioni MG, Pittaluga E, Ticino A, Parasassi T. A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine. Evid Based Complement Alternat Med. 2013;2013:240702.
  • [7] Stey C, Steurer J, Bachmann S, Medici TC, Tramèr MR. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J. 2000 Aug;16(2):253-62.
  • [8] Stav D, Raz M. Effect of N-acetyl cysteine on air trapping in COPD: a randomized placebo-controlled study. Chest. 2009 Aug;136(2):381-6.
  • [9] Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A. A Review on Various Uses of N-Acetyl Cysteine. Cell J. 2017;19(1):11-17. doi:10.22074/cellj.2016.4872
  • [10] Sandhir R, Sood A, Mehrotra A, Kamboj SS. N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington’s disease. Neurodegener Dis. 2012;9(3):145-57.
  • [11] Shungu DC. N-acetylcysteine for the treatment of glutathione deficiency and oxidative stress in schizophrenia. Biol Psychiatry. 2012 Jun 1;71(11):937-8.
  • [12] https://pubmed.ncbi.nlm.nih.gov/25339490/

Gut Microbiome test

Gut Microbiome test

Autism and Genes, Digestion, Health, Microbiome and Gut health

A gut microbiome test is needed if any kind of abdominal, neurological, or skin complaint is present. It gives relevant information on gut health.

 

 

 

Research shows that your gastrointestinal (GI) system state (or your “gut”) influences your overall health.

While certain symptoms, such as indigestion, mood changes, and skin diseases, could point to imbalances in the gut, these exact connections can only be understood through testing.

This is where microbiome testing could potentially play a role.

A gut microbiome test is a new diagnostic way to get a picture of your overall health.

Microbiome testing measures the amount and types of microbes in your gut, such as bacteria and viruses, via a stool sample. While such tests may be conducted in a doctor’s office, there are at-home tests too when you have to complete the microbiome testing kits on your own.

A gut microbiome refers to the microbes that exist in your digestive system. The intestines, stomach, colon, and esophagus are all important members of your GI tract, and they all contain microbes that affect the digestion process.

Composition of the gut microbiome

You probably know that billions of microorganisms live in our bodies, mostly located in the gastrointestinal tract.  The human genome consists of about 23,000 genes, whereas our microbiome encodes over 3 million genes that produce thousands of metabolites. This means that in the human body there is a superorganism that plays an important role.

Everyone has a unique microbiota like a personal fingerprint and this means that gut microbiota composition is mostly unique to each individual, like an individual identity card.

Current evidence points mostly towards that humans live in a sterile environment in the womb and infants only start being colonized by microbes when going through the vaginal passage, or during skin contact with parents or the medical team. The human microbiota is established in this phase and starts as a dynamic ecosystem that stabilizes during the first 2–3 years.

 

Composition is influenced by:

  • Feeding methods (breast milk, artificial milk, and introduction of solid food);
  • Medication (antibiotics, acid suppressants, drugs);
  • Dietary habits; environment and lifestyle; and weight gain.
  • Genetics factors;
  • Anatomical parts of the intestinal tract (e.g. the large intestine has a higher microbial diversity compared with the small intestine);
  • Gestational age (preterm or full-term birth); delivery mode (vaginal delivery or C-section); and aging.
    The microbiomes have many essential functions in the body: from helping digestion and producing vitamins to supporting the development of the immune system and preventing infections.
  • Impressively there are also interactions between gut microbes and the brain which means we may be able to support mental health by changing the gut microbiome.
  • The microbiome functions as an extra organ, that uses nutrients from ingested foods to produce a large number of compounds, including vitamins, short chain fatty acids (SCFAs), and essential amino acids. The gut microbiome, through metabolite production and fermentation, helps the intestine to maintain its equilibrium. When a balanced interaction between the gastrointestinal (GI) tract and the resident microbiota is disrupted, intestinal and extra-intestinal diseases may develop.
When there’s an imbalance of gut microbes, various health effects may occur as a result. Common symptoms of gut disruptions may include bloating, stool changes, and heartburn,diarrhea,mood swings,skin disorders such as eczema,POD ( peioralis dermatitis)and rashes on any part of the body, SIBO, inflammation, insuline resistance…and so on.

Furthermore
Your gut health affects your brain through neurotransmitters (serotonin contributes to feelings of happiness, gaba – gamma- aminobutyric reduces anxiety ) and these neurotransmitters are produced by gut cells and gut microbes.

Why test your microbiome?

The primary purpose of this type of stool testing is to analyze microbes and potential imbalances in your GI system. This kind of stool sample analysis can provide clues to potential inflammatory conditions or autoimmune diseases, such as inflammatory bowel disease (IBD) and Celiac disease.
By testing your gut microbiome, you can learn more about the functions of your gut microbiome and check that it is helping to keep you healthy and not contributing to making you sick. Using a metagenomic gut microbiome test, you will learn your potential to break down nutrients and discover the potential of your gut microbiome to break down macronutrients such as fiber, protein, simple sugars, and fats.
obtain a comprehensive list of the microbial species present
Whether it’s a well-known species or newly discovered, you will get a full list of the different bacteria and archaea present in your gut.

Receive tailored guidance from a Microbiome Coach

If the detailed information about the result of your microbiome test is not enough for you, it is possible to ask for help from a Microbiome coach who helps in evaluating your test result. Gain a deeper understanding of your Insight™ report and discuss your personalized shopping list of food suggestions with a qualified health professional.

Resources
  • [1] https://pubmed.ncbi.nlm.nih.gov/28743984/
  • [2] https://pubmed.ncbi.nlm.nih.gov/30025401/
  • [3] https://pubmed.ncbi.nlm.nih.gov/27812084/
  • [4] https://pubmed.ncbi.nlm.nih.gov/28512250/
  • [5] Thriene K. et al. Effects of Fermented Vegetable Consumption on Human Gut Microbiome Diversity—A Pilot Study. Fermentation. ;8(3).(2022).
  • [6] Sarka A et al. Pychobiotucs and the Manipulation of Bacteria-Gut-Brain Signlas. Trends in Neurosciences. (2016).
  • [7] Bear T et al. The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress. Microorganisms. (2021)
  • [8] Miranda-Comas G. et al. Implications of the Gut Microbiome in Sports. Sports Health (2022).
  • [9] Day AW. et al. Gut Microbiome Dysbiosis in Alcoholism: Consequences for Health and Recovery. (2022).
  • [10] Leclercq S. et al. Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms. Transl Psychiatry. ;11(1):503. (2021).
  • [11] Seo B et al. Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice. Cell host & microbe. ;27(1):25-40.e6. (2020).
  • [12] Flikkema J. The Relationship Between the Gut Microbiome and Sleep Examined Through Associated Human Disease. University Honors Theses. (2022).
  • [13] Han M. et al.. The interplay between sleep and gut microbiota. Brain Research Bulletin. (2022).
Foods in SIBO

Foods in SIBO

Digestion, Health, Microbiome and Gut health, SIBO

In the next “Foods in SIBO” list, you can find all kinds of food you can eat if you are struggling with SIBO, but you can also use this list if you have abdominal discomfort or IBS.

If you have SIBO, avoiding carbohydrates from your diet is essential. SCD, LFD, GAPS, and FODMAP diets and their variants are the most popular diets recommended to people struggling with SIBO.

All these diets are based on low carbohydrate intake because this feeds pathogens.

The only carbohydrate that bacteria do not eat much of is insoluble fiber. Below you can find most of the food consumed if you have SIBO.

“Foods in SIBO” list

If you have SIBO, you should avoid any carbohydrates. In the “Foods in SIBO” list, you can find all the food that can be consumed

Quality Protein Sources

  • Bone soup
  • Eggs (quail eggs only)
  • Pumpkin seed
  • Organic grass-fed lamb
  • Organic pasture poultry (chicken, duck, turkey)
  • Hydrolyzed bovine collagen
  • Vegan protein: rice, hemp, pea, etc.

Healthy Fats

  • Coconut, coconut oil, coconut flour, coconut + butter / semolina / milk / yogurt / cream
  • Ghee (if you tolerate)
  • Grape seed oil
  • Olive oil
  • Flaxseed oil

Alternatives for diary products

  • Coconut milk, yogurt, cream
  • Oat milk
  • Rice milk
sibo food coconut

Bio, Non-Starch Vegetable

  • Sprouts (including broccoli, radishes and sunflower sprouts)
  • Artichoke
  • Asparagus
  • Bean sprouts
  • Broccoli
  • Brussels sprouts
  • Cabbage
  • Cauliflower
  • Celery
  • Cucumber
  • Fennel
  • Onions
  • Green onions
  • Turnips
  • Herbs (parsley, coriander, basil, rosemary, thyme, dill, lemongrass, etc.)
  • Kohlrabi
  • Leek
  • Salad (baby salad, iceberg lettuce)
  • Peppers (green, red, yellow, orange jalapeno)
  • Radish
  • Rhubarb
  • Onions
  • Swiss chard
  • Watercress
  • Zucchini

sibo food broccoli

Delicious spices

  • Anise
  • Basil
  • Bay leaf
  • Cocoa beans
  • Cayenne
  • Coriander / coriander
  • Cinnamon
  • Clove
  • Cumin
  • Dill
  • Ginger
  • Ground black pepper
  • Mint
  • Nutmeg
  • Oregano
  • Paprika
  • Parsley
  • Red chili flakes
  • Rosemary
  • Sea salt
  • Stevia
  • Tarragon
  • Thyme
  • Curcuma
  • Vanilla
sibo food spices

Drinks

  • Bone soup
  • Coconut milk
  • Smoothies
  • Tea, herbal, decaffeinated
  • Water

Gluten-Free Flour

  • Arrow root starch
  • Coconut flour
  • Sweet potato flour
  • Tapioca flour

Bone soup

Fruits

  • Apples
  • Apricots
  • Blueberries
  • Blackberries
  • Redcurrant
  • Cherry
  • Cranberries
  • Figs
  • Goji berries
  • Gooseberry
  • Solo
  • Kiwi
  • Lychee
  • Mango
  • Melon
  • Mulberry
  • Nectarine
  • Passionfruit
  • Peach
  • Pear
  • Persimmon
  • Plum
  • Pomegranate
  • Quince
  • Raspberry
sibo food mango

Starched vegetables after SIBO treatment 

  • Carrot
  • Chestnut
  • Jerusalem artichoke
  • Parsley
  • Potato
  • Pumpkin
  • Sweet potatoes
artichoke SIBO
sibo products

More articles on SIBO

Five facts about SIBO

Treatment of SIBO

Symptoms and causes of SIBO

Diagnosis of SIBO

SIBO aggravating factors

Facts about SIBO
SIBO treatment
Symptoms, causes
Diagnosis
Aggravatings

Leaky Gut

Leaky Gut

Autism and Genes, Digestion, Microbiome and Gut health, SIBO

Symptoms and causes

Symptoms and causes

Normally, the bowel does not leak. However, if there is a problem with the intestinal tract, the intestinal wall can also penetrate, leading to inflammation.

On the one hand, the intestines must be sufficiently permeable to absorb nutrients and fluids. Still, they also need a defense mechanism that retains harmful substances and pathogens. The nutrients come from the outside world, i.e., many microorganisms, chemicals, and toxins are ingested daily through food and drink, which enter the body through the intestinal tract.

Formation of Leaky Gut Syndrome

The gut as a defense system

The first stop of this defense system is the barrier, i.e. the gut flora, or as it is now called: the microbiome.

The beneficial bacteria in the gut flora are capable of:

  •  To destroy pathogens
  • “Filters out” various toxins, carcinogens,
  • to produce substances that nourish the cells of the intestinal wall,
  • they also take part in mucus production, which involves the inner surface of the gut,
  • They make B vitamins, folic acid, short-chain fatty acids,
  • “Inform” the immune system of the presence of pathogens and harmful substances.

The second line of defense is the intestinal epithelial cell

In the gut, this is done by a specialized epithelial cell (epithelium), which is made up of only one layer. The intestinal mucosa is damaged by SIBO and does not ingest the pathogens due to inflammation; the duct between the intestinal cells remains open, allowing pathogens and toxins to enter the bloodstream, causing inflammation in other parts of the body, in addition to food sensitivities. Allergies develop. If SIBO is not treated for a long time, autoimmune processes may start.

The third line of defense is the gut’s immune system which is 70-80% of all immune cells in the body.

Leakage in the gut can also be caused by gluten, as gluten triggers the production of zonulin in the gut. Zonulin is a protein found in the small intestine that regulates the opening and closing of a channel between intestinal cells. When the zonulin rises, it opens the nodes, and the nodes close when the zonulin level falls down. This protein is activated by gluten, which elevates zonulin and opens nodes in the channels between intestinal cells.
While many suspect celiac diseases as the cause of their problems, SIBO is often the case.

Zonulin can also be activated and elevated by infections such as Candida overgrowth, SIBO, and parasites, and exposure to toxins and stress can all cause leaking intestinal tract.

Symptoms of a leaky gut

  • Digestive problems such as bloating, diarrhea, irritable bowel syndrome (IBS)
  • Food allergy or food intolerance
  • Brain fog, difficulty concentrating, Attention Deficit
  • Hyperactivity Disorder (ADD) or Attention Deficit Hyperactivity Disorder (ADHD)
  • Mood imbalances such as depression and anxiety, decreased ability to manage stress
  • Skin problems such as acne, rosacea, or eczema
  • Seasonal allergies or asthma
  • Hormonal imbalances such as irregular menstruation, premenstrual syndrome (PMS), or polycystic ovary syndrome (PCOS)
  • Diagnosis of autoimmune diseases such as rheumatoid arthritis, Hashimoto’s thyroiditis, lupus, psoriasis, or celiac disease
  • Diagnosis of chronic fatigue or fibromyalgia

Causes of a leaky gut

So the following can lead to the development of leaky gut syndrome:

  • colonization of harmful pathogens in the intestine
  • food allergies
  • Hidden food intolerances: these are very insidious because
  • intolerance usually develops to food that is consumed often, even every day but does not cause immediate symptoms. (gluten, casein, eggs)
  • long-term medication, antibiotics
  • digestive enzyme deficiencies
  • hormonal changes
  • abnormal fluctuations in blood sugar levels
  • persistent stress
  • Accumulation of chemicals, and toxins in the intestine

10 signs of leaky gut

  1. Chronic diarrhea, constipation, gas or bloating
  2. Nutritional deficiencies
  3. Poor immune system
  4. Headaches, brain fog, memory loss
  5. Excessive fatigue
  6. Skin rashes and problems such as acne, eczema or rosacea
  7. Cravings for sugar or carbs
  8. Arthritis or joint pain
  9. Depression, anxiety, ADD, ADHD
  10. Autoimmune diseases

If you are experiencing these symptoms, consider talking to your healthcare provider and test your microbiome with the newest technology to find out what is happening inside your gut. Re-rebuilding the gut microbiome and repairing the intestinal wall is essential to stay healthy for the long term.

Resources
  • 1] https://pubmed.ncbi.nlm.nih.gov/33171587/
  • [2] https://pubmed.ncbi.nlm.nih.gov/32902315/
  • [3] https://pubmed.ncbi.nlm.nih.gov/23851019/
  • [4] https://pubmed.ncbi.nlm.nih.gov/30394372/

    Treatment of SIBO

    Treatment of SIBO

    Microbiome and Gut health, SIBO

    It is very important to note again that if you notice any symptoms of SIBO and it starts to get worse, for example, food runs through the digestive system in 1 hour and it seems to be undigested, see a doctor immediately. Antibiotic (rifaximin) is usually given to treat SIBO, which only works in the gut. 1 cure may not be enough.

    I had 5. However, if your symptoms return despite medication, you can to try the alternative suggestions below. If the symptoms of SIBO have resolved with rifaximin, it is still advisable to use the alternative protocol mentioned below.

    Remember, this is your intestinal system, the health of which affects many physiological processes, so your quality of life is highly dependent on the health of your intestinal system. It is worth maintaining it even after recovery.

    Treatment of SIBO

    Steps you need to follow!

    Don’t feed the pathogens

    Effective treatment of SIBO begins by inhibiting the growth of bacteria. The first step is to remove the foods that feed the bacteria. These include sugar, alcohol, and all kinds of carbohydrates. Intake of complex carbohydrates such as cereals, beans, pumpkins, or sweet potatoes, only low-sugar fruits can be eaten.
    With SIBO, starch-free vegetables, leafy vegetables, lean colds and healthy fats can be consumed and it is worth avoiding gluten and dairy products for a while.
    Other inflammatory foods, corn, soy, refined sugar, GMOs and other processed foods should also be excluded from the diet. At the same time, it is advisable to follow an elimination diet for histamine intolerance, ie it is recommended to eat foods with a low histamine content. You can find the list of dishes you can eat in

    Eridication of pathogens

    Unfortunately only by diet you won’t really managet get rid of SIBO permanently. Antibiotics may be needed in almost all cases. There are 2 active substances used abroad, one is Rifaximin, the other is effective against hydrogen-dominant SIBO and the other is more successful than methane-dominant SIBO. Rifaximin (Normix) is used at home. These antibiotics are essential to kill pathogens with specific SIBO symptoms with the least amount of damage to the good bacteria in your microbiome.
    After a course of antibiotics, someone who has severe or recurrent symptoms may want to take Berberin as a cure to prevent the symptoms from returning. Berberine is a wonderful drug.
    In addition to its many positive physiological effects (promoting weight loss, supporting the cardiovascular system, etc.), it destroys pathogens from the intestinal tract.

    Effect of berberine on SIBO

    Berberin inhibits the growth of pathogenic bacteria that cause diarrhea, thereby relieving the symptoms of diarrhea. SIBO can be a great help in case of intestinal inflammation problems.
    Insulin resistance often develops as a result of intestinal problems. The blood sugar optimizing effect of Berberin prevents the development of insulin resistance and reverses existing insulin resistance, promotes weight loss

    It also inhibits Candida overgrowth, SIBO and prevents leakage. Berberine does not choose between good and bad bacteria, but it does less harm to good bacteria than antibiotics. It is worth taking it with a probiotic, but while the eradication is in progress, only soil bacteria should be taken, followed by others. This will be discussed later.
    You can find Berberin in the webshop here: Berberin

    If you have a rash, Oregano capsules can be good to take as a fire extinguisher due to its antimicrobial effect.

    Initial malaise

    Although many patients feel better soon after starting treatment, there are those who experience the negative effects of bacterial death almost immediately. Dying bacteria often begin to produce amounts of toxins that the body cannot handle, causing unpleasant symptoms. You should not be afraid if you notice any of the following symptoms:

    • Brain fog
    • Memory impairment
    • Dizziness
    • Headache
    • Fatigue
    • Anxiety or irritability
    • Gas formation, bloating
    • Diarrhea or constipation
    • Joint and muscle pain

    Although the symptoms are not pleasant, they indicate that you are well on your way to recovery.
    3 detoxification options if you are very bothered by the above symptoms:
    Sit in an infrared sauna, which is tolerated relatively well by the body, even in the case of histamine intolerance, so that toxins are cleared quickly through sweating.
    Soak yourself in bitter water for half an hour. The epsom salt breaks down into magnesium and sulfates and is absorbed through the skin, reducing muscle pain, cramps and even detoxifying (put 30g of epsom salt and 30g of baking soda in 1 tub of water)
    Take a charcoal tablet. Carbon binds toxins and removes them from the body.
    In all three cases, drink a lot. Preferably 3 l of clean water.

    Restore good bacteria

    It is a very important step to restore good bacteria in the gut for optimal digestion and absorption of nutrients.
    It is advisable to take a probiotic only after the antibiotic and only what has been detected in the Intestinal genome or a simpler intestinal flora status test. If you are not taking a probiotic to make up for the missing bacteria in your gut, you are not actually doing anything, but you may even be doing yourself a foul because an overgrowth of good bacteria can result in SIBO !!!!

    Among the good bacteria in the small intestine, lactobacillus or bifidobacterium species tend to multiply. The small intestine is not meant for bacteria to rest in it. Since most probiotic preparations contain lactobacillus or bifidobacteria, using this type of probiotic will only increase the bacteria in your small intestine by throwing oil on the fire. This is why it is very important to know the composition of your intestinal flora.

    In the case of SIBO,

    it is recommended to use only soil-based probiotics to reduce symptoms, regardless of the condition of the intestinal flora. They contain innovative strains of bacteria that efficiently produce highly bioavailable antioxidants and riboflavin, precisely at the site of absorption. Riboflavin is an essential nutrient for maintaining a healthy digestive system. Soil-based probiotics do not aggravate the symptoms because they do not colonize the small intestine or nourish the bacteria that are already growing there. So they do not populate the small intestine, but start to multiply in the colon.
    Probiotic in the webshop at LactoSpore probiotic

    You may also want to consume a digestive enzyme to prevent the fermentation of food due to your poor digestion, which is good for bad bacteria.
    You can find a digestive enzyme in the webshop: Opti7 Dygest Enzyme

    Treatment of leaking gut

    The treatment of leaking gut can be speeded up by taking quality L-Glutamine. L-Glutamine strengthens the intestinal mucosa, helps cells produce more mucus and more Immunoglobulin A, regenerates intestinal wall cells, closes the duct openings between intestinal wall cells.
    You can buy it here in the webshop: Glutamine

    STRESS MANAGEMENT

    Introduce a perfect stress-relieving routine into your everyday life so that your body can regenerate with peace of mind, such as:
    Infrared sauna therapy 2x a week
    Mild exercise: yoga or long walks, cycling
    Body massage, foot massage
    Avoid evening blue light exposure which can disturb your sleep as good night’s sleep is essential for proper recovery and recovery

    SIBO treatment summary

    1. Low FODMAP Diet
    2. Berberine -Antimicrobial effect
    3. Dygest Enzyme – Digestive Support
    4. Glutamine – Treatment of leaky gut
    5. Soil based Probiotics – Intestinal Regeneration

    If you have Microbiome test done, you can take probiotics according to the result of the test but only after antibiotic or Berberine treatment.

    A 1-2 week course of oregano oil is also recommended to maintain the condition. Berberine kills also good bacteria, so it is only recommended for SIBO symptoms or severe diarrhea. In milder cases, oregano is better.

    Five facts about SIBO

    Foods in SIBO

    Symptoms and causes of SIBO

    Diagnosis of SIBO

    SIBO aggravating factors

    Facts about SIBO
    Foods in SIBO
    Symptoms, causes
    Diagnosis
    Aggravatings
    Resources
    [1]

    Wijendran V, Huang MC, Diau GY, et al. Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonates. Pediatr Res 2002;51:265-272.

    [2]

    Goustard-Langelier B, Guesnet P, Durand G,et al. n-3 and n-6 fatty acid enrichment by dietary $sh oil and phospholipid sources in brain cortical areas and nonneural tissues of formula-fed piglets. Lipids 1999;34:5-16.

    [3]

    Maki KC, Reeves MS, Farmer M, et al. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr Res 2009;29:609-615.

    [4]

    Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004:9:420-428.

    [5]

    Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-179.

    [6]

    Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr 2007:26:39-48.

    [7]

    Chang JP, Chen YT, Su KP. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) in cardiovascular diseases (CVDs) and depression: Cardiovasc Psychiatry Neurol 2009;2009:725310. Epub 2009 Sep 27.

    [8]

    Breslow J. n-3 fatty acids and cardiovascular disease. Am J Clin Nutr 2006;83:1477S-1482S.

    [9]

    Calzolari I, Fumagalli S, Marchionni N, DiBari M. Polyunsaturated fatty acids and cardiovascular disease. Curr Pharm Des 2009;15:4094-4102.

    [10]

    No authors listed. Phosphatidylcholine. Altern Med Rev 2002;7:150-154.

    [11]

    Naguib YM. Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem 2000;48:1150-1154.

    [12]

    Tso P, Drake DS, Black DD, Sabesin SM. Evidence for separate pathways of chylomicron and very low-density lipoprotein assembly and transport by rat small intestine. Am J Physiol 1984;247:G599-G610.

    [13]

    Amate L, Gil A, Ramirez M. Feeding infant piglets formula with long-chain polyunsaturated fatty acids as triacylglycerols or phospholipids influences the distribution of these fatty acids in plasma lipoprotein fractions. J Nutr 2001;131:1250-1255.

    [14]

    Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic osteatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 2009;57:9339-9345.

    [15]

    Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th ed. New York, NY: Garland Science; 2002.

    [16]

    Else PL, Hulbert AJ. Membranes as metabolic pacemakers. Clin Exp Pharmacol Physiol 2003;30:559-564

    [17]

    Kidd PM. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Altern Med Rev. 2007 Sep;12(3):207-27.

    [18]

    Konagai C, Yanagimoto K, Hayamizu K, Han L, Tsuji T, Koga Y. Effects of krill oil containing n-3 polyunsaturated fatty acids in phospholipid form on human brain function: a randomized controlled trial in healthy elderly volunteers. Clin Interv Aging. 2013;8:1247-57.

    [19]

    Ebrahimi M, Ghayour-Mobarhan M, Rezaiean S, et al. Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Acta Cardiol. 2009 Jun;64(3):321-7.

    [20]

    Derosa G, Cicero AF, Fogari E, et al. Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load. J Clin Lipidol. 2012 Nov-Dec;6(6):553-64.

    [21]

    Spencer M, Finlin BS, Unal R, et al. Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Diabetes. 2013 May;62(5):1709-17.

    [22]

    Yan Y, Jiang W, Spinetti T, et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013 Jun 27;38(6):1154-63.

    [23]

    Valensa. FlexPro MD Clinical Trial Overview and Results. (Data on File.) 2011

    [24]

    McCann JC, Ames BN. Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr 2005;82:281-295.

    [25]

    Stevens LJ, Zentall SS, Abate ML, et al. Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiol Behav 1996;59:915-920.

      How I developed Intestinal Dysbiosis

      How I developed Intestinal Dysbiosis

      Microbiome and Gut health, SIBO

      Let’s start with a bit of concept definition. Intestinal dysbiosis  (1) (also known as dysbacteriosis) is a disturbance of the balance of the intestinal flora. In this case, the beneficial bacteria in the gut are damaged. In that case, their numbers are reduced, and they will not be able to perform their beneficial effect, i.e., to suppress the pathogenic microbes in the intestine or to perform their additional function in the digestive process. Thus severe digestive problems can develop.

      Most of the time, suppressing pathogenic microorganisms requires an additional course of antibiotics, damaging the beneficial gut flora and creating a vicious circle. Beneficial bacteria also have a digestive function; if they are not present in the gut in sufficient numbers, certain nutrients are not digested well, and many complaints, bloating, and pain can occur during the digestive process.

      I was given Metronidazole as a therapeutic agent for a parasitic infection that I should have taken for at least ten days. For so long, because in the cystic life cycle of the parasite (Entamoeba Hystolytica), the drug only kills the developed parasite, useless in the cystic stage. Thus, there may be cysts in the intestinal wall that are in the pre-developmental location and not only the developed parasites; if cysts remain in the body, the therapy will fail.

      On the 8th evening, I started to feel dizzy and thought I had tachycardia. I didn’t take my metronidazole dose that night. After waiting for two hours, I decided I didn’t want to be alone in that state for the night, grabbed myself, got in the car, and went to my parents. I didn’t want to scare them, so I didn’t say how bad I felt, but when they saw me, they knew exactly.

       

      I was awake and terrified all night. I didn’t sleep for a minute because I had pain in my chest, and I felt tachycardia. I got up early in the morning and went to the bathroom to brush my teeth when a strange thing happened. Have you ever seen a faucet from which water flows in a different shade due to the color environment that hits the water? After brushing my teeth, I discovered a bluish water jet when I rinsed my mouth. I looked up and opened my mouth, and suddenly I couldn’t speak. My tongue was black!

      Little red bumps appeared around my mouth and nose and hurt extremely. Head to ER. An ECG, abdominal ultrasound, and CT were needed because of the entamoeba infection; it can rarely cause an abscess in the brain or liver, which can be fatal. All were negative. The diagnosis is intestinal dysbiosis which caused my tongue to blacken.
      This phenomenon exists as a black hairy tongue. Yes, it is hairy because the tongue’s papillae protrude and elongate, fortunately only temporarily. The reasons for this can be poor oral hygiene, smoking, a lot of coffee, and tea, a weak immune system, dehydration, and a long course of antibiotics, which upsets the balance of microorganisms. I think the last two might have come into play: dehydration check mark, an antibiotic-induced intestinal dysbiosis check mark….and what followed…

      Dysbiosis, Salmonella, Clostridium Difficile, SIBO, Perioralis Dermatitis, Duodenal Ulcer, Vertigo, Histamine Intolerance.

      But you probably have read the detailed story here: My gut healing story

      My Gut Healing Story

      My Gut Healing Story

      Microbiome and Gut health, SIBO

      Ten years. That’s exactly how many days have passed since I decided at Christmas to finally find out what is causing the half-yearly abdominal problems and diarrhea. Three months later, it turned out that a tropical parasite, Entamoeba Histolytica (1) had caused my complaints.

      Everybody has a story. Now you can read mine, which is about how I got rid of the symptoms of dysbiosis and several other intestinal infections, including histamine intolerance, after this dangerous parasitic infection.

      Ten years ago I ate a salad at a canteen of a spring conference. When I got home, I was sure that something terrible had happened. I couldn’t get out of the bathroom for hours.  My life has radically changed since that day. It took me ten months to discover that this dangerous parasite caused my symptoms.
      Fecal fertilization is standard in the Mediterranean or Tropical zone. In early spring, most of the vegetables are imported from these areas.
      Entamoeba Hystolitica spreads with feces and can travel in cystic form for a long time, for example, on the surface of a cucumber, and can’t be washed off.
      You can eat the cyst of the parasite mainly with contaminated vegetables or drink it with water. My symptoms started 1 hour after I ate the salad containing imported, unpeeled cucumber.

      Symptoms

      The symptoms can include loose stools, stomach pain, cramping, less frequent bloody stools, and fever. In some cases, this amoeba penetrates the liver, lung, or brain and forms an abscess, which is very uncommon.

      Due to the cystic reproduction of the parasite, it is excreted from the body intermittently, i.e., when it develops, it usually causes symptoms when it is designed and can be tested in the stool. The symptoms depend on the extent of the infection.

      Treatment

      The treatment is Metronidazole and/or Tinidazole for amoebiasis. I had to take high doses of Metronidazole for ten days. The drastic extermination of this parasite has had consequences for years. I took a high amount of antibiotics, but I didn’t take any probiotics with it. Before this happened, I had been entirely healthy; I didn’t think ten days of antibiotics would determine my life that much for the next ten years. 

      After eight days of taking Metronidazole, I started to feel dizzy one night. The parasite caused sudden dizziness anyway; I thought it was the side effect of the medicine killing them. My heart was beating very hard, I had pain in my chest, I couldn’t sleep, and I realized that my tongue was blackened in the morning.

      …and what followed

      Dysbiosis

      Intestinal dysbiosis has developed due to the high-dose oral antibiotic. I was sent to abdominal and brain CT to be sure that Entamoeba had not attacked my liver or brain.

      Salmonella

      4 weeks after the Metronidazole treatment, I had become infected with Salmonella. I had to take Sulfamethoxazole to treat the infection.

      Clostridium Difficile

      2 weeks after the Salmonella infection, due to the control stool test, it turned out that I had been infected with Clostridium Difficile. I had to take probiotics only because the treatment of Clostridium Difficile is also Metronidazole or, in severe cases, Vancomycin, but the doctors knew that I was in a bad condition, so they wanted to wait 2 weeks and repeat the test after taking probiotics. Fortunately, it was negative, so there was no need to take antibiotics again.

       SIBO

      My gut was completely damaged. I was taking probiotics, and sometimes I was fine, but nothing was the same when I was completely healthy. 4 months later, I went to a wellness hotel with my husband for some days. We went to the jacuzzi and sauna every day, so we just enjoyed our stay. On the fourth day at night, I felt dizziness again, but it was extreme vertigo, and I had severe diarrhea. I felt so bad that I had to go to the ER. I got an infusion, and they sent me home. The following day I needed another injection again because of vertigo. I got better, but I wasn’t well. After one month, all food went through me undigested in 1 hour. The gastroenterologist sent me to do an H2 breath test to diagnose SIBO, but I knew immediately that I had SIBO based on the symptoms. Other symptom were extremely painful perioral dermatitis on my face and continuous pain around my liver.

      Perioral Dermatitis

      Extremely painful perioral dermatitis (POD) developed on my face due to my terrible gut health if you have POD, itis useless to treat with steroids because it always relapses until the root cause is treated.

      Duodenal Ulcer

      The SIBO was so stubborn that I got five doses of rifaximin to treat SIBO, but after the fifth dose, I developed a duodenal ulcer. If I had known about berberine, I would have skipped the fifth dose of rifaximine and replaced the antibiotics with it.

      Vertigo

      I had to go to the ER every two months because of severe vertigo. It took me five years to discover that my dizziness, lightheaded feeling, and vertigo were caused by histamine intolerance. 

      SIBO treatment

      If your SIBO always relapses, don’t give up and try something natural. It would be best if you got rid of SIBO to avoid the long-term consequence of this health issue, such as metabolic syndrome or autoimmune health problems. 

      Read the Natural Remedies of SIBO article, where you can find product recommendations with detailed descriptions and SHOP links.

      Gut and skin

      Gut and skin

      Digestion, Health, Microbiome and Gut health, Natural skincare, SIBO

      The link between gut and skin health

       

      If you have skin rashes or eczematous symptoms, you should never think it is a genetic condition.

      If you have long-term, chronic symptoms, you should not only see a dermatologist or switch to natural cosmetics but also remember that digestive problems and internal parasites could be behind the external symptoms.

      In nutritional studies, the skin has long been considered an indicator of intestinal issues and an imbalance of intestinal flora.

      To have clear, healthy skin, you should first regenerate your gut.

      Epidemiological studies show a clear link between intestinal problems and skin diseases.

      When skin problems do not respond properly to skin care treatments, the source of the problem is actually in the gut. A poorly functioning gut system can potentially exacerbate or lead to pre-existing skin conditions. Acne, rosacea, and perioral dermatitis are ten times more likely to occur with small intestinal bacterial infections (SIBO). Skin rashes occur in 14% of patients with ulcerative colitis and 24% with Crohn’s disease. Mucosal lesions, alopecia, and vitiligo are also more common in gluten sensitivity. Skin problems and acne may occur due to increased intestinal permeability (leaky gut) in inflammatory bowel disease.

      Studies have shown that intestinal inflammation and dysbiosis can impair the skin’s protective function. This condition, in turn, leads to a decrease in the number of antimicrobial peptides produced in the skin and may increase the severity of certain infections as part of the skin’s inflammatory response

      The intestinal flora influences the health of the skin

      The condition of the intestinal flora affects the health of the skin. The so-called neuropeptide substance P is produced in the intestine, brain, and skin and plays an essential role in the condition of the skin. An altered gut microbiome releases higher neuropeptide P levels in the gut and the skin. Higher levels of neuropeptide P affect lipid production and fatty acid profiles in tissues and can influence sebum production and fatty acid composition of sebum. Several studies have already demonstrated the positive effects of probiotics on the skin.

      Gut-skin axis

      “The GSA describes the relationship where the gut can influence skin health owing to its immunological and metabolic properties.52 Although it is difficult to strictly attribute a cause-and-effect relationship between the gut microbiome and dermatologic conditions, multiple studies support a connection between them with several cutaneous diseases being associated with GI disorders and vice versa.”(1)

      Several studies have already demonstrated the beneficial effects of probiotics on the skin. Fermented dairy products have a positive effect on intestinal flora, while unfermented dairy products can promote acne breakouts. However, be careful with fermented products if you suffer from SIBO. Oral probiotics reduce inflammation and systemic oxidative stress markers, which are locally elevated in acne. However, if you do not know anything about your microbiome, it is recommended to take only high-quality soil-based probiotics.

      “Gut microbiota influence the pathophysiology of acne via cross-talk between intestinal commensal bacteria and the mTOR pathway ()” (2)

      A well-balanced, nutrient-rich diet is critical to maintaining a healthy gut. If you do not have any particular intestinal problems, you can take probiotic supplements to increase the versatility of your intestinal flora.

      Quercetin, a powerful antioxidant, and a miracle molecule can still be beneficial. Since I have been taking Quercetin regularly, I have not had a single pimple, although I am sure that my intestinal flora is not 100% perfect.

      What can you do to improve your digestion and skin?

      • Avoid dairy, soy, gluten, and rapidly absorbable carbohydrates for at least 1-2 months.
      • Take probiotics daily. Preferably something that has been studied and proven to be effective. If you have intestinal problems, take only soil-based probiotics.
      • In the case of digestive problems, take regular “digestive enzymes ” to help your digestion, which will relieve your heavy stomach immediately after a large meal. If you do not take a digestive supplement, incorporate apple cider vinegar into your daily routine, preferably the unfiltered variety. After a meal, a tablespoon will help digest the food. It is important to support digestion with natural supplements when altered intestinal flora and impaired digestion slow down the digestion of food because, in this case, there is stagnation in the small intestine, which causes many unpleasant symptoms and inflammation.
      • Move around whenever you can!
      • I am thinking of something other than going to the gym every day. However, you should walk as much as possible if you do not have time to exercise. Introduce a 15-minute workout at a faster pace 3x per week to work your muscles and speed up your metabolism.
      • Take evening primrose oil, as its gamma-linolenic acid content reduces the symptoms of eczema, and take omega-3 capsules (1000 mg ) 2-3 times a day to reduce inflammatory processes.

      Stick to the above for at least 2-3 months, and follow a diet high in fiber, and you will surely see the change!

      Resources
      [1]

      https://www.sciencedirect.com/science/article/abs/pii/S0738081X21001930

      [2]

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048199/

      [3]

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916842/

      [4]

      https://www.dermatologytimes.com/view/gut-bacteria-linked-to-inflammatory-skin-disease

      [5]

      https://pubmed.ncbi.nlm.nih.gov/33924414/

      [6]

      Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr 2007:26:39-48.

      [7]

      https://pubmed.ncbi.nlm.nih.gov/27554239/

      [8]

      https://pubmed.ncbi.nlm.nih.gov/33921772/

      [9]

      https://pubmed.ncbi.nlm.nih.gov/33540138/

      [10]

      https://www.eurekalert.org/news-releases/903431

      [11]

      Demirel Ogut N. Link Between the Gut and Inflammatory Skin Disease Exposed. Accessed May 11, 2021. Published online May 7, 2021. https://www.eurekalert.org/pub_releases/2021-05/sc-tro050621.php

      [12]

      Stocum, Linda. “Gut Bacteria Linked to Inflammatory Skin Disease.” https://www.dermatologytimes.com/, 11 May 2021, www.dermatologytimes.com/view/gut-bacteria-linked-to-inflammatory-skin-disease.

      [13]

      Juhl, Christian R, et al. “Dairy Intake and Acne Vulgaris: A Systematic Review and Meta Analysis of 78,529 Children, Adolescents, and Young Adults.” Nutrients, U.S. National Library of Medicine, 9 Aug. 2018, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115795/.

      [14]

      Sanz, Yolanda. “Effects of a Gluten-Free Diet on Gut Microbiota and Immune Function in Healthy Adult Humans.” Gut Microbes, U.S. National Library of Medicine, 2010, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023594/.

      [15]

      Acne Vulgaris – Statpearls – NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK459173/.

      [16]

      Demirel Ogut N. Link Between the Gut and Inflammatory Skin Disease Exposed. Accessed May 11, 2021. Published online May 7, 2021. https://www.eurekalert.org/pub_releases/2021-05/sc-tro050621.php

      [17]

      Stocum, Linda. “Gut Bacteria Linked to Inflammatory Skin Disease.” https://www.dermatologytimes.com/, 11 May 2021, www.dermatologytimes.com/view/gut-bacteria-linked-to-inflammatory-skin-disease.

      [18]

      Juhl, Christian R, et al. “Dairy Intake and Acne Vulgaris: A Systematic Review and Meta Analysis of 78,529 Children, Adolescents, and Young Adults.” Nutrients, U.S. National Library of Medicine, 9 Aug. 2018, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115795/.

      [19]

      Sanz, Yolanda. “Effects of a Gluten-Free Diet on Gut Microbiota and Immune Function in Healthy Adult Humans.” Gut Microbes, U.S. National Library of Medicine, 2010, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023594/.