Unlocking the Health Benefits of Butyrate: The Power of a Gut-Healthy Fatty Acid

Unlocking the Health Benefits of Butyrate: The Power of a Gut-Healthy Fatty Acid

GABA and autism connection

The human body is a remarkable and intricate system of interconnections. One such fascinating connection lies within our gut – a vast ecosystem of microorganisms known as the gut microbiota. This community of “good bacteria” plays a crucial role in maintaining our overall health and well-being. Among the numerous byproducts generated by these microbes, one stands out for its potent health-promoting properties – butyrate.

What is Butyrate?

Butyrate, a short-chain fatty acid, is produced by certain gut bacteria through the fermentation of dietary fibers. It serves as an essential energy source for the cells lining the colon and plays a vital role in maintaining a healthy gut environment. Apart from its role as an energy provider, butyrate boasts several health benefits, earning it the reputation of a “gut-healthy” fatty acid.

Butyrate and Gut Health

One of the primary roles of butyrate is in promoting gut health. By nourishing the cells lining the colon, it helps maintain the integrity of the intestinal barrier. This barrier acts as a selective gatekeeper, preventing harmful substances from entering the bloodstream and promoting the absorption of essential nutrients.

A healthy intestinal barrier contributes to improved digestion and immune function while reducing the risk of inflammation and digestive disorders.

Anti-Inflammatory Properties

Inflammation is a natural response of the body to injury or infection, but chronic inflammation can lead to various health issues. Butyrate has been shown to possess anti-inflammatory properties, helping to regulate the body’s immune response. By curbing inflammation, butyrate may help alleviate symptoms in conditions such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).

Potential Impact on Brain Health

Research exploring the gut-brain axis – the bidirectional communication between the gut and the brain – has shed light on the potential impact of butyrate on brain health. Studies in animals have suggested that butyrate may influence gene expression and cellular processes in the brain, potentially supporting cognitive function and even offering neuroprotective effects. While more research is needed in this area, these early findings are intriguing and offer exciting possibilities for future investigations.

Weight Management and Metabolic Health

Some studies have indicated that butyrate might play a role in weight management and metabolic health. It has been associated with improved insulin sensitivity and may help regulate appetite and reduce fat storage. However, it’s important to note that while butyrate shows promise in this area, maintaining a balanced diet and a healthy lifestyle remain the cornerstones of weight management and metabolic well-being.

Sources of Butyrate

Ensuring adequate levels of butyrate in the gut involves maintaining a balanced and fiber-rich diet. Foods that are high in dietary fiber, such as whole grains, vegetables, and legumes, can serve as fuel for gut bacteria to produce butyrate. Additionally, fermented foods like yogurt and sauerkraut may also provide a source of beneficial gut bacteria that contribute to butyrate production.

The Future of Butyrate Research

While much progress has been made in understanding the potential health benefits of butyrate, the field of gut microbiota research is still relatively young. As scientists delve deeper into the intricacies of the gut-brain axis and the role of butyrate in various physiological processes, we can expect more exciting discoveries in the future.

Conclusion

Butyrate, the gut-healthy fatty acid, is a remarkable example of the intricate relationship between our gut and overall health. From promoting gut integrity and mitigating inflammation to potentially supporting brain health and metabolic well-being, butyrate demonstrates its versatile potential as a health-promoting compound. By maintaining a balanced diet and nurturing our gut microbiota through fiber-rich foods, we can unlock the powerful benefits of butyrate and pave the way for a healthier and happier life.

As with any health-related information, it’s essential to consult with healthcare professionals for personalized advice and recommendations. Embracing the journey of understanding the gut-brain connection and the wonders of butyrate might indeed hold the key to unlocking a healthier future.

Resources

 

 

The link between diet and microbiome

The link between diet and microbiome

diet and microbiome

The composition of the microbiome of the intestinal flora is influenced by several external and internal environmental factors: genetics, age, gender, and so on. Of all the external factors examined so far, dietary habits have the greatest effect on the composition of the intestinal flora.

Recent studies have suggested that the intestinal microbiome plays an important role in modulating the risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. At the same time, it is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary microbial shifts within 24 h. Given this association, there may be significant therapeutic utility in altering microbial composition through diet. (1)

Stool microbiome studies show that the composition of the intestinal flora responds dynamically to the introduction of a new diet, however, if this new diet lasts only a short time, it is not sufficient to permanently restore the dysbiosis seen in diabetes, for example.

Differences in the microbiota are influenced by the housing location, hospitalization, rehabilitation, long-term home care, and diet. Microbiotas of people under long-term care are significantly less diverse than others and the elderly living separately are weaker, more fallible. Deteriorating health is indicated by the change in the structure of the gut microbiota, caused by the diet (2).

The composition of the gut microbiota is also influenced by fiber intake, even during adulthood. The effect of the fibers is that the Bacteroidetes/Firmicutes ratio increases, because of an increase in the number of the former, however, the body mass index is not related to this. The total of the bacterial genes of fiber consumers was similar but different from the microbiome of those ignoring fiber (3).

Food choice is manipulated by the microbiota, but at the same time, the microbiota can be manipulated also by food choice. Gut microbes can send signals to the brain through neural connections (nervus vagus), and thus urge people to consume foods that are necessary for optimal living conditions of the microbiota and the suppression of their competitors, regardless of whether this is beneficial for the „host” or not. The usual diet is satisfactory for certain members of the microbiota, but maybe it is not for others, and these can modify desires for food. For example, Prevotella requires carbohydrates for propagation, while dietary fibers mean a competitive advantage for Bifidobacteria, and it is exactly this competition that determines which group stays alive and becomes dominant. In overweight / obese individuals, an imbalance of the intestinal flora is also observed.

A microbiome study of people with a Western lifestyle found that a diet high in fiber and carbohydrates increased the proportion of Prevotella bacteria, while a diet rich in fat and protein favored the Bacteroides group. In overweight individuals who have been on a low-calorie, low-calorie, low-calorie diet for at least a year, the rate of Bacteroidetes: Firmicutes has increased. This change was greater the more weight the subjects in the experiment managed to get rid of. Also in the study of obese/overweight individuals, it was found that after a 6 + 6-week low-calorie, protein-rich diet, their metabolism was improved and the species richness of the intestinal flora was increased. However, the same change was negligible for individuals who had a more species-rich intestinal flora from the beginning.

To assert their interests, microbes quasi capture the nervous system of the host organism by exploiting the microbiome-gut-brain axis. In addition to the neural pathway, microbes can modify the secretion and operation of hormones influencing mood and behavior (dopamine, serotonin), and of certain receptors (e.g. taste), and can modify dietary preferences. Prebiotics, probiotics, fecal transplants, dietary changes can modify the microbiome even within a single day.

Now we know that gut microorganisms have been shown to play a role in a wide range of human diseases, including obesity, psoriasis, autism, and mood disorders. The close relationship between diet, the gut microbiome, and health suggests that we may improve our health by modulating our diet.
Further investigations have revealed more specific roles for some bacterial species in mediating host immunity and immunologic diseases. For example, the segmented filamentous bacteria have been found to promote autoimmune arthritis. On the other hand, lactic acid bacteria and Bifidobacteria are known to secrete factors that dampen inflammation

Intestinal SCFAs have also been shown to protect against allergic airway inflammation and decrease the secretion of several pro-inflammatory cytokines. Besides immunity, gut microorganisms have also been shown to impact host metabolic health. Individuals with metabolic disorders such as obesity and diabetes have been shown to have intestinal dysbiosis in relation to healthy individuals. Further characterization of the link between the gut microbiome and obesity has revealed several bacterial groups that may specifically contribute to the disease. In particular, obese individuals have a high baseline Firmicutes to Bacteroidetes ratio. In these subjects, reduction of caloric intake was noted to lower the Firmicutes to Bacteroidetes ratio. Intriguingly, hosts with a gut microbiome dominated by Firmicutes have altered methylation in the promoters of genes that are linked to cardiovascular disease and obesity. Additionally, Lactobacillus spp. has been shown to alleviate obesity-associated metabolic complications. The beneficial effects of Lactobacillus may be attributed to interactions with obesity-promoting bacteria in the gut and direct modulation of host immunity and gut barrier function. (4)

Although microbiome testing has undergone tremendous development over the past decade, the exact role of the intestinal microbiome in the development and maintenance of obesity, diabetes, or other disease remains unanswered. Despite, the next generation microbiome testing can help to detect all species of bacteria and along with the use of the existing knowledge it is now possible to develop some kind of therapies, recommend targeted diets that can help to balance the microbiome and prevent the development of the above diseases by correcting dysbiosis.

 

What is Dysbiosis

What is Dysbiosis

The beneficial bacteria are useful participants in our gut flora. The condition of our intestinal flora greatly affects our health. Dysbiosis is when the number of beneficial bacteria in the gut decreases and harmful bacteria, fungi, or parasites multiply. In the last ten years, we have seen a dramatic increase in the incidence of intestinal dysbiosis, in which both environmental and lifestyle factors play a major role.

Changes in the microbiome 

Changes to your gut microbiome also called your gut flora, may occur because the different organisms in your gut are not at the right levels.

As a result, a wide range of digestive tract-related symptoms happenssuch as diarrhea, cramping, obstruction, bloating, and indigestion. 

When your gut microbiome loses its diversity of bacteria, it can increase your risk of getting a chronic disease.

When your gut microbiome gets imbalanced and dysbiosis happens you are more likely to have stomach, intestinal skin, or other health conditions. Do these conditions include?

IBS, IBD

Cardiovascular problems

Obesity

Central nervous system disorders

Diabetes

Chron, Colitis

Allergic disorders

ADHD, Autism

Histamine intolerance, MCAS

There are at least 400 species of bacteria found in mainly our large intestine. They are essential for overall health as they aid in digestion, fight off pathogenic microorganisms, and synthesize vitamins.

There are three types of dysbiosis

Type 1. the number of good bacteria from your gut has been decreased

Type 2. harmful bacteria are already proliferated

Type 3. you lost your overall gut microbiome diversity. This means you lost both the good and the bad bacteria

What can cause dysbiosis

Excessive or wrong use of antibiotics,

Excessive alcohol consumption,

Increased intake of sugar or protein,

Frequent use of antacids,

Exposure to pesticides,

Chronic stress

Poor dental hygiene 

How to rebalance your microbiome

First of all, you need to rule out other possible causes of your digestive symptoms such as SIBO or parasites. For proper treatment, you should test your microbiome to detect the pathogens that are colonized in your gut, and probiotics that are missing.

Personalized supplement recommendations are fundamental for success and you will need to follow a microbiome diet for at least  6 weeks.

Is your child a picky eater?

Is your child a picky eater?

Is your child a picky eater

Many parents have trouble understanding and coping with their children’s picky eating habits. Children who are picky eaters have a strong sense of independence and self-determination.

What is picky eating?

Picky eating refers to a pattern of behavior in which a person is selective or picky about the foods they will eat, often eating only a narrow range of familiar and preferred foods and avoiding or rejecting new or different foods. It can be a normal part of childhood development, but in some cases, it can become persistent and problematic, leading to a limited and inadequate diet and potentially to nutritional deficiencies or other health problems.

What is the connection between picky eating and autism?

Picky eating is commonly associated with autism spectrum disorder (ASD). Studies have found that children with autism are more likely to have particular eating habits, which can cause nutritional deficiencies and other health problems. The reasons for the higher incidence of picky eating among individuals with autism are not well understood, but it is thought to be related to sensory sensitivities, difficulties with transitions and change, and an overall preference for routine and structure in their environment, including in their diet.
It’s important to note that while picky eating is common in individuals with autism, not all individuals with autism have picky eating habits, and not all individuals with picky eating habits have autism. If a child is having difficulty with feeding or nutrition, it’s recommended to seek the advice of a healthcare professional.

Is there any relation between picky eating and neurotransmitters?

Some evidence suggests that picky eating may be related to neurotransmitter imbalances in the brain. Neurotransmitters regulate mood, appetite, and other bodily functions.
For example, low serotonin levels, a neurotransmitter involved in regulating mood and appetite, have been associated with increased food cravings, impulsivity, and compulsive behaviors, which can contribute to picky eating. Similarly, low levels of dopamine, which is involved in motivation and reward, have been linked to decreased interest in food and reduced pleasure in eating.
However, while there is a relationship between neurotransmitter imbalances and picky eating, it is complex and not fully understood.

How to balance neurotransmitter levels in the brain?

There are several ways to balance neurotransmitter levels in the brain:
1. Diet: Consuming a healthy, balanced diet with plenty of fresh fruits and vegetables, whole grains, lean protein, and healthy fats can help support neurotransmitter balance.
2. Exercise: Regular physical activity has been shown to increase the release of neurotransmitters like dopamine, endorphins, and serotonin, which can help improve mood and reduce stress.
3. Stress management: Chronic stress can disrupt neurotransmitter balance. Practicing stress-reducing activities such as meditation, yoga, or deep breathing can help.
4. Sleep: Getting enough sleep is important for maintaining neurotransmitter balance. Poor sleep can disrupt neurotransmitter levels, while adequate sleep can help support neurotransmitter function.
5. Supplements: Some people may benefit from natural supplements like amino acids, vitamins, and minerals that support neurotransmitter production and function. However, it’s important to consult a healthcare professional before starting any new supplement regimen.

So neurotransmitter synthesis can affect the eating habits of a child. If you experience that your child is a picky eater, you should test his methylation and microbiome state to rule out methylation dysfunction and probable pathogens from the gut that can affect neurotransmitter synthesis.

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The Autism Guide

ou will find more details in the AUTISM GUIDE

Resources
Some facts about the relation of Autism and gut microbiome

Some facts about the relation of Autism and gut microbiome

autism and gut microbiome

The relationship between autism and gut microbiome is another area of science that has received much attention. It is now well known that 30-50% of people with autism suffer from significant gastrointestinal problems such as diarrhea, constipation, and irritable bowel syndrome, and more have microbiome imbalance.

Autism spectrum disorder (ASD)

Autism spectrum disorder (ASD) is a severe neurodevelopmental or neuropsychiatric disorder. Cognitive disabilities, communication disorders, repetitive patterns of behavior, and limited social interaction and communication are primary signs of autism. Most gastrointestinal problems associated with autism suggest that it is not merely a psychiatric disorder, as many claims, but has a physiological basis, and alleviating gastrointestinal problems can help relieve symptoms. bIntestinal dysbiosis or microbial imbalance can disrupt the coordination of the microbiota-gut-brain axis, which is important in human mental health; as the common saying goes, “fix your gut, fix your brain”.

Microbes in the gut

It has long been a mystery why, but there is now excellent evidence that the complex community of microbes plays a vital role in human development and is essential for a healthy immune and endocrine system as well as the brain.
Some scientists believe that disturbing the natural balance of these “good” bacteria could be a possible cause of autism. Antibiotics, for example, are commonly used in infants in Western societies and are known to kill “good bacteria” along with the “bad” bacteria for which they are prescribed.

Differences in the microbial community humans can rely on during evolution can disrupt brain development and lead to autism. The evidence for this possible cause of autism is not strong, but significant research will be conducted in this area in the coming years.

Autism and gut microbiome

Writing about intestinal health issues can be tricky since so many kinds of issues affect each person in unique ways. However, one thing is certain across the board: the correlation between gastrointestinal health and mental development. Here are some other interesting findings regarding intestinal health and its relationship to autism.

What we know

The gut microbiome is a diverse ecosystem of microorganisms living within the intestinal tract that can impact physical, mental, and social health. In recent years, there has been growing interest in understanding how the gut microbiome may affect autism. Research is still ongoing in this area, but some individuals with autism may be missing key organisms necessary for proper brain development. Several studies have shown differences in microbiota composition and microbial metabolites in children with ASD. The connection between gut microbiota and ASD symptoms may be based on the gut-brain axis and immune, hormonal or neuronal pathways. Researchers found strong associations between gut microbiota and ASD symptoms. Studies in mice suggest that the gut microbiome can influence our behavior by acting through the gut-brain axis.

The gut microbiome has recently been shown to impact the development of autism and other neurological disorders.

Recent findings in the field of microbiology show a direct link between brain activity and gut microbes due to the gut-brain axis, demonstrating that the gut microbiota may influence several neurological disorders, such as autism. As we already know, the microbial fermentation of plant-based fibers can produce different levels of short-chain fatty acids (SCFA), which will have different outcomes but definitely affects the gut and the neurological development of autistic children. Intestinal dysbiosis has also been linked to an increased risk for neurobehavioral disorders like autism spectrum disorder. Research has shown that some ASD patients are suffering from gastrointestinal distress; therefore, evidence suggests a direct connection between their conditions due to the increased presence of microbes within their guts. Further study into what makes up this connection—the so-called microbiota-gut-brain axis—may even lead researchers to develop potential treatments for neurological disorders that cause fewer side effects than others (Krajmalnik-Brown et al., 2015).
Restoring the gut microbiome and following a restricted diet free from gluten and casein can help with the symptoms of autism

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Resources

https://www.frontiersin.org/articles/10.3389/fcimb.2022.915701/full#B61

Lactoferrin for iron defficiency

Lactoferrin for iron defficiency

Lactoferrin for iron deficiency

Lactoferrin (LF) is an iron-binding glycoprotein found in the milk of mammals such as humans therefore it can help with iron deficiency.

 

 

 

If you are constantly tired or short of breath after a little exercise, you probably have an iron deficiency. SIBO, or a parasitic infection, almost always causes iron deficiency.

If you are iron deficient, you should take LACTOFERRIN along with iron-rich foods to utilize the iron instead of just letting it circulate in your blood and cause oxidative stress.

Symptoms of iron deficiency

  • fatigue
  • weakness
  • headache
  • dizziness
  • pallor
  • hair loss
  • palpitations
  • throat tightness
  • swallowing disorders
  • reduction of load capacity

Lactoferrin has been found to exert physiological effects such as antimicrobial and antiviral activity, modulation of cell growth, and immunomodulatory effects. It was also found that the iron binding capacity of LF is about 300 times greater than that of transferrin. (9) It has been confirmed that LF regulates iron absorption.10-13) Recently, oral lactoferrin has been reported to increase serum hemoglobin and total iron in pregnant women.

Anemia is commonly observed in athletes, especially endurance athletes, and is referred to as sports anemia or in children or pregnant women. In particular, long-distance runners who menstruate and strictly control their weight can easily develop sports anemia.

LF significantly improved the hematological parameters. Our results suggest that it might be useful to take not only iron but also LF (an iron-binding protein) for the prevention of iron deficiency anemia.

If ferrous salts are circulating in the blood because the body cannot utilize them, then they are causing severe oxidative stress. Lactoferrin helps to bind and utilize serum iron, therefore also preventing oxidation.

In addition to Lactoferrin, you should do the following to increase your iron levels and improve your iron deficiency:

  • Eat foods rich in iron
    Meat and eggs
    Beetroot
    leafy greens
    Sesame
    Spinach
    Sweet potatoes
    Pea
    Broccoli
    Green beans
    Turnips
    Cereals
    Strawberry
    Watermelon
    Raisins
    Dates
    figures
    Prunes
    Sesame
  • Introducing Huminiqum
  • Screening for digestive system inflammations
  • Virus removal
  • Identification of drugs that inhibit iron absorption
Whey Protein

Whey Protein

whey protein

Terra Origin – whey protein

Probably you did not know until now, that whey protein isolate could increase intracellular GSH (glutathione) concentrations and protect against oxidant-induced cell death all over the body, including gut cells. 

Whey Protein assists the body in maintaining optimal concentrations of Glutathione (GSH) by supplying the precursors required for intracellular glutathione synthesis. 

Glutathione is a tripeptide made intracellularly from its constituent amino acids L-glutamate, L-cysteine, and glycine. The sulfhydryl (thiol) group (SH) of cysteine is responsible for the biological activity of Glutathione. The provision of this amino acid is the rate-limiting factor in glutathione synthesis by the cells since bioavailable cysteine is relatively rare in foodstuffs.

Glutathione is a master antioxidant and has several health benefits; among others, Glutathione is present in the entire intestinal mucosa, where it traps and neutralizes potential toxins before they are absorbed into the body. Glutathione protects the intestinal wall, which, if weakened, can lead to a leaking / permeable intestinal problem. See more benefits here: Glutathione

Butyric acid

Butyric acid

Butyric acid is a short-chain fatty acid believed in providing optimal benefit to the gastrointestinal tract. It is highly produced in the gut by bacterial fermentation of undigested carbohydrates such as dietary fiber.Butyric acid has been scientifically shown to support and promote the health of the GI tract and microbiome.

 

 

Butyrate is an essential source of energy for the intestinal epithelium. It plays a crucial role in regulating the proliferation and differentiation of epithelial cells, protecting immune function and mucous membranes. Butyrate has antitumor activity and antimicrobial effect against the most enteric pathogens, thereby significantly improving the composition of gut microflora.

Indigestible carbohydrates (prebiotics) increase colonic butyrate concentration, which is thought to be responsible for its beneficial effects. In inflammation caused by oxidative stress, damage to the integrity of cell-cell connections and an increase in cell permeability may occur, depending on the extent and duration of the oxidative effect.
The therapeutic value of the protective n-butyrate improves the intestinal epithelium’s barrier function, maintains a healthy intestinal flora, and promotes the regeneration of intestinal epithelial cells.

Butyric acid treatment

Decrease in cell layer resistance induced by acute oxidative stress after low-dose butyrate treatment decreased, indicating that the role of a mechanical barrier is strengthened. Based on experimental results, the composition of the intestinal flora has become favorable.
The number of beneficial lactic acid bacteria and the amount of L-lactic acid they produce in the small intestine also increased. Butyrate affects the coliform bacteria; it can also be used effectively to prevent and overcome the development of infectious conditions in the intestinal tract.

Butyrate controls pathogenic bacteria through regulating intestinal oxygen availability. Several studies have reported another important mechanism where butyrate can indirectly control pathogenic bacterial overgrowth, i.e. contributing to intestinal oxygen availability 

Specific benefits of Butyrate for the gut:

Maintenance of normal intestinal bacteria
Increased absorption of macronutrients
It is an essential element of intestinal homeostasis
Improves tight junctions in leaky gut
Improves the mucus layers of the gut
Helps gut cells to kill pathogens
Keeps the oxygen levels in the colon low
Regeneration of the intestinal mucosa
Reduces the incidence of IBS symptoms
Intestinal pain after antibiotic treatment

But Butyrate has shown benefits for the whole body

Supports mast cells and modulates histamine
Supports the immune system by lowering inflammation and helping reduce autoimmunity
May improve skin issues
May help with allergies and asthma
Can protect against alcohol-induced leaky gut and inflammation
It is considered cancer protective has shown anticancer effect
In mice, studies showed improvement in insulin sensitivity, mitochondrial density, and satiety after eating
In mice, research showed it helped the brain recover from strokes
Support weight loss with increasing Bacteroidetes in the gut. – Firmicutes and Bacteroidetes are two major groups in the gut. Having more Firmicutes than Bacteroidetes is associated with weight gain and obesity.

How it works:

4 levels of leaky gut:

Loosening of the tight junctions in the gut lining – allows food and other things to pass through to the bloodstream
Loss of mucus layer in the gut
Low good bacteria species
Loss of ability to kill pathogens in the gut

Butyrate’s effect on leaky gut:

Improves the tight junctions in the gut lining
Supports healing mucus layers in the gut
Increases good bacteria in the gut
Supports cells to kill pathogens in the gut
Butyrate supports the gut at the cellular level.

Studies have shown that people who have the following conditions tend to be low in butyrate:

Inflammatory Bowel Disease
Crohn’s Disease
Ulcerative Colitis
Irritable Bowel Syndrome (IBS)
IBS-C (constipation-dominant)
IBS-D (diarrhea-dominant)
Type 1 diabetes
Obesity
Rheumatoid Arthritis
Parkinson’s DiseaseHo
Children with allergies

How do you know whether or not you have healthy butyrate levels?

Find out the signs of low butyrate!
To have good butyrate levels, you need to know if you have the suitable microbiome species in your gut and if you need to eat enough fibers or to be fermented, and during this process, butyrate will be produced. Your butyrate levels wcorrectecrease if you don’t have the right species of bacteria or enough prebiotics in your diet.

How do you fix your butyrate levels?

You need to have butyrate-producing bacteria, but unfortunately, only one of these bacteria is available commercially – Lactobacillus rhamnosus.
So, unfortunately, there is no good recommendation to increase your butyrate levels, so you need to focus on fiber and prebiotics.

What to do, then?

You have to eat a variety of vegetables.
Increase your intake of resistant starch, but if you don’t tolerate fiber and starch, it can be a problem and leads to a vicious circle.

The only thing you can do is choose the correct type of butyrate supplement.

When choosing, you need to consider the…:

  • type of butyrate is very fragile; butyrate needs to bond with salt that stabilizes it. But research shows that tributyrin is more potent and doesn’t require digestion to break apart the chemical bonds.
    Plus, some research suggests tributyrin is safer for human consumption than butyrate salts.
  • the butyrate delivery: Butyrate will be broken down in the stomach and won’t reach the gut. To avoid this, you need to choose liposomal or so-called enteric delivery. Unfortunately, the liposomal butyrate is very smelly
  • purity (without additives)
  • easy to use

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