Environmental Toxins and Their Impact on Neurotransmitters

Among various toxins, pesticides have a profound effect on the brain. These neurotoxic chemicals can disrupt multiple neurotransmitters, including acetylcholine, dopamine, serotonin, endorphins, oxytocin, histamine, norepinephrine, and GABA. Many pesticides primarily target GABA by inhibiting its activity, specifically designed for this purpose.

Toxins produced by Candida can lead to surges in glutamate production. Additionally, a wide range of other toxins, including mold toxins, bacterial toxins, Lyme disease, and organic solvents, can also cause similar glutamate surges. Dr. Rick Sponaugle, a brain expert, highlights how toxins released by bacteria in the mouth causing gingivitis and periodontal disease can lead to increased glutamate activity, resulting in symptoms like anxiety.

Mycotoxins, toxins produced by mold and fungi, are of particular interest due to their impact on glutamate. Studies suggest that mycotoxins may significantly increase glutamate release, potentially leading to elevated glutamate levels in individuals living in mold-damaged homes or those with previous mold exposure.

GABA supplementation is often recommended to increase GABA levels and decrease glutamate. However, some individuals may experience stimulating effects from GABA supplementation, possibly increasing glutamate levels. The GABA shunt, a complex metabolic pathway responsible for GABA production and regulation, plays a critical role in this process.

The GABA shunt involves a closed-loop process aimed at producing and preserving GABA. However, individuals with conversion issues may experience a build-up of glutamate instead of GABA. Consequently, supplementing with GABA may not be beneficial for everyone, as excess GABA can convert back to glutamate.

Dr. Datis Kharazzian, a brain expert, uses GABA supplementation as a screening tool for identifying leaky brain conditions. GABA should not be able to cross the blood-brain barrier, but if it does, it indicates a leaky brain. Using GABA supplements, even with positive effects, may lead to the downregulation of GABA receptor sites, potentially causing withdrawal symptoms when discontinuing supplementation.

NAC, known as a glutamate scavenger, may be suggested to increase GABA levels. However, it also increases glutathione, which can raise glutamate levels. The impact of NAC on GABA and glutamate balance varies from person to person.

Phenibut and L-theanine are popular choices for increasing GABA levels. However, phenibut’s artificial stimulation can lead to addiction and depletion, while L-theanine, as a glutamate analog, may cause excess glutamate in some individuals. Care should be taken when using these substances.

Lithium orotate is another option used by some practitioners to regulate GABA levels. It may be a more suitable alternative for individuals who experience issues with GABA conversion.

Many manufacturers and health care practitioners may not fully comprehend the impact of glutamate. Consequently, nutritional supplements, even those from reputable brands, may contain excitotoxins. Individuals prone to excess glutamate must exercise caution when choosing supplements.